Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder

Mehmet Solakhan; Burak Bilgin

doi:10.5798/dicletip.620366

Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder

Abstract

Objective: We aimed to test ocular and systemic safety of mirabegron medication in the treatment of overactive bladder in elderly patients.

Method: A total of 74 patients (40 male, 34 female) with symptoms of overactive bladder admitted to the urology clinic were included in the study. Patients over 60 years old were included. Patients were followed-up for 3 months. Symptom scores (according to OAB-V8 form), intraocular pressure (IOP) readings of right and left eyes, systolic and diastolic blood pressures of the patients were recorded before and after the treatment. At the end of 3 months, all values were re-evaluated and compared with pre-treatment data.

Results: Mean age was 69.48±7.8 years. The symptom score was found to be 18.67 ± 9.87 before the treatment and 9.83 ± 2.71 after 3 months of the treatment (p=0.0001). Right eye mean IOP value was 16.06 ± 2.62 mmHg before treatment and 15.85 ± 2.31 mmHg after treatment (p=0.341). Left eye mean IOP value was 15.96±2.35 mm mmHg before treatment and 15.94±2.21 mm after treatment (p=0.855). Systolic blood pressure measurements were 128.91±11.76 mmHg before treatment and 128.43±11.95 mmHg after the treatment (p=0.110). Diastolic blood pressure measurements were 81.94±9.83 mmHg before the treatment and 81.31±10.14 mmHg after the treatment (p=0.071).

Conclusion: Treatment of overactive bladder with mirabegron 50mg/day is well tolerated and safe in elderly patients.

Keywords

Overactive bladder; β3-adrenoreceptor agonist; Oculer safety.

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Mehmet Solakhan ^*
0000-0001-9123-9196

Burak Bilgin This is me
0000-0001-6332-2371

Publication Date

September 16, 2019

Submission Date

February 4, 2019

Acceptance Date

July 29, 2019

Published in Issue

Year 2019 Volume: 46 Number: 3

DOI

https://doi.org/10.5798/dicletip.620366

IZ

https://izlik.org/JA26RY66UM

Cite

RIS / Bibtex

APA

Solakhan, M., & Bilgin, B. (2019). Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Medical Journal, 46(3), 429-434. https://doi.org/10.5798/dicletip.620366

AMA

1.Solakhan M, Bilgin B. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Medical Journal. 2019;46(3):429-434. doi:10.5798/dicletip.620366

Chicago

Solakhan, Mehmet, and Burak Bilgin. 2019. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Medical Journal 46 (3): 429-34. https://doi.org/10.5798/dicletip.620366.

EndNote

Solakhan M, Bilgin B (September 1, 2019) Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Medical Journal 46 3 429–434.

IEEE

[1]M. Solakhan and B. Bilgin, “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder”, Dicle Medical Journal, vol. 46, no. 3, pp. 429–434, Sept. 2019, doi: 10.5798/dicletip.620366.

ISNAD

Solakhan, Mehmet - Bilgin, Burak. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Medical Journal 46/3 (September 1, 2019): 429-434. https://doi.org/10.5798/dicletip.620366.

JAMA

1.Solakhan M, Bilgin B. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Medical Journal. 2019;46:429–434.

MLA

Solakhan, Mehmet, and Burak Bilgin. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Medical Journal, vol. 46, no. 3, Sept. 2019, pp. 429-34, doi:10.5798/dicletip.620366.

Vancouver

1.Mehmet Solakhan, Burak Bilgin. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Medical Journal. 2019 Sep. 1;46(3):429-34. doi:10.5798/dicletip.620366