The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection

Salih Yıldırım; Yavuz Orak; Rukiye Menemencioğlu; Ahmet Altun; Filiz Orak; Cevdet Düger; Esra Özpay; Fatih Mehmet Yazar

doi:10.5798/dicletip.620514

The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection

Abstract

Objective: Aim of study is to determine which antibiotic is started empirically in the ICU and to investigate whether the antibiotic started according to culture result was changed or not and the effect of this change on mortality, and to investigate the relationship between mortality and infection by determining whether enteral and parenterally fed patients have attained sufficient calorie level.

Method: After the approval of the local ethics committee, the files of 476 patients hospitalized in our hospital were retrospectively reviewed. A total of 159 patients over 18 years of age who received mechanical ventilation therapy for at least 3 days were included in the study. Blood, urine and tracheal aspirate culture were determined. It was recorded whether antibiotics had changed according to the culture result. Nutritional patterns, number of feeding days and basal caloric need were determined. It was investigated whether basal calorie need was met on 1, 3 and 5 days. Factors affecting mortality were investigated.

Results: Antibiotic exchange was significantly higher in the patients who died (P = 0.002). Mortality was higher in patients who were unable to reach the target calorie (P = 0.01). Empirical changes in antibiotics (r: 0.174, P = 0.028), and culture positivity (r: 0.177, P = 0.026) were associated with mortality (r: 0.195, P = 0.014). In the subgroup analysis, reproduction in tracheal aspirate culture was an important factor affecting mortality (r: 0.211 P: 0.008).

Conclusions: The number of days of hospitalization, antibiotic change, culture positivity and inability to reach the target calories in nutrition are associated with mortality in the intensive care unit.

Keywords

empirical antibiotic therapy,mortality,intensive care unit

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Salih Yıldırım This is me
0000-0002-4986-6812

Yavuz Orak ^* This is me
0000-0002-8356-6223

Rukiye Menemencioğlu This is me
0000-0002-7053-8143

Ahmet Altun This is me
0000-0003-2056-8683

Filiz Orak This is me
0000-0001-5153-7391

Cevdet Düger This is me
0000-0002-3845-8733

Esra Özpay This is me
0000-0003-0187-9910

Fatih Mehmet Yazar This is me
0000-0002-1780-6962

Publication Date

September 16, 2019

Submission Date

April 11, 2019

Acceptance Date

July 11, 2019

Published in Issue

Year 2019 Volume: 46 Number: 3

DOI

https://doi.org/10.5798/dicletip.620514

IZ

https://izlik.org/JA27FX48HJ

Cite

RIS / Bibtex

APA

Yıldırım, S., Orak, Y., Menemencioğlu, R., Altun, A., Orak, F., Düger, C., Özpay, E., & Yazar, F. M. (2019). The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection. Dicle Medical Journal, 46(3), 489-498. https://doi.org/10.5798/dicletip.620514

AMA

1.Yıldırım S, Orak Y, Menemencioğlu R, et al. The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection. Dicle Medical Journal. 2019;46(3):489-498. doi:10.5798/dicletip.620514

Chicago

Yıldırım, Salih, Yavuz Orak, Rukiye Menemencioğlu, et al. 2019. “The Use of Empirical Antibiotics in Intensive Care Unit and Relationship Between Nutrition and the Incidence of Infection”. Dicle Medical Journal 46 (3): 489-98. https://doi.org/10.5798/dicletip.620514.

EndNote

Yıldırım S, Orak Y, Menemencioğlu R, Altun A, Orak F, Düger C, Özpay E, Yazar FM (September 1, 2019) The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection. Dicle Medical Journal 46 3 489–498.

IEEE

[1]S. Yıldırım et al., “The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection”, Dicle Medical Journal, vol. 46, no. 3, pp. 489–498, Sept. 2019, doi: 10.5798/dicletip.620514.

ISNAD

Yıldırım, Salih - Orak, Yavuz - Menemencioğlu, Rukiye - Altun, Ahmet - Orak, Filiz - Düger, Cevdet - Özpay, Esra - Yazar, Fatih Mehmet. “The Use of Empirical Antibiotics in Intensive Care Unit and Relationship Between Nutrition and the Incidence of Infection”. Dicle Medical Journal 46/3 (September 1, 2019): 489-498. https://doi.org/10.5798/dicletip.620514.

JAMA

1.Yıldırım S, Orak Y, Menemencioğlu R, Altun A, Orak F, Düger C, Özpay E, Yazar FM. The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection. Dicle Medical Journal. 2019;46:489–498.

MLA

Yıldırım, Salih, et al. “The Use of Empirical Antibiotics in Intensive Care Unit and Relationship Between Nutrition and the Incidence of Infection”. Dicle Medical Journal, vol. 46, no. 3, Sept. 2019, pp. 489-98, doi:10.5798/dicletip.620514.

Vancouver

1.Salih Yıldırım, Yavuz Orak, Rukiye Menemencioğlu, Ahmet Altun, Filiz Orak, Cevdet Düger, Esra Özpay, Fatih Mehmet Yazar. The use of empirical antibiotics in intensive care unit and relationship between nutrition and the incidence of infection. Dicle Medical Journal. 2019 Sep. 1;46(3):489-98. doi:10.5798/dicletip.620514