Prognostic factors in Guillain-Barre syndrome

Abstract

Objective: Guillain–Barre syndrome (GBS) is an immune-mediated disorder of peripheral nerves resulting as acute inflammatory demyelinating polyradiculoneuropathy. GBS has a heterogeneous clinical course and laboratory findings. Acute onset and progressive course, and is usually associated with a good prognosis but some forms have a poor prognosis. Factors that can affect the prognosis of GBS have been investigated in several studies. Assessment of poor prognostic factors of GBS plays a vital role in the management and monitorization of patients. Methods: In this retrospective study of patients admitted to the acute phase of GBS removing clinical and laboratory profiles and was planned to investigate the prognostic factors. Results: Totally 23 patients (Female/male: 16/7) were recruited. Mean age was 47 (range: 17-70) years. Statistically significant poor prognostic factors were advanced age (p=0.042), erythrocyte sedimentation rate (p=0.027) and serum albumin level (p=0.007). Conclusion: Advanced age, increased ESR and decreased albumin levels were found as poor prognostic factors in GBS.

Keywords

• Guillain-Barre syndrome, advanced age, sedimentation, albumin

Guillain-Barre sendromunda prognostik faktörler

Abstract

Amaç: Guillain-Barre Sendromu (GBS), oldukça yaygın görülen otoimmün kökenli, periferik sinirleri etkileyen akut inflamatuar demiyelinizan bir poliradikülopatidir. Oldukça heterojen klinik ve laboratuvar bulgularıyla karşımıza çıkabilir. Ani başlangıçlı, progresif seyirli ve çoğunlukla iyi prognozludur. Ancak bazı formları kötü seyirlidir. GBS\'nin prognozunu etkileyebilen faktörler çeşitli çalışmalarla araştırılmaktadır. Prognostik faktörlerin bilinmesi hastaların tedavi ve izlem planlarında önemli rol oynayabilir. Yöntemler: Bu retrospektif çalışmada akut dönem GBS olarak izlenen hastaların klinik ve laboratuvar profillerinin çıkarılması ve prognostik faktörlerin araştırılması planlandı. Bulgular: Çalışmaya GBS tanısı almış 7 erkek, 16 kadın (toplam 23 hasta) dahil edildi. Yaş ortalamaları 47 yıl (17- 70 arası) idi. İleri yaş (p=0,042), ileri parezi varlığı (p=0,030), sedimantasyon (ESR) (p=0,027) ve serum albümin (p=0,007) düzeyleri prognostik faktörler olarak bulundu. Sonuç: İleri yaş, artmış sedimentasyon hızı, ve azalmış albümin düzeyleri hastalık prognozu üzerine olumsuz etkili olarak bulundu.

Keywords

• Guillain Barre sendromu, ileri yaş, sedimantasyon, albümin

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