Clinical and demographic characteristics of Guillain-Barre syndrome

Abstract

Objective: We aimed to assess the epidemiological, clinical, laboratory, electrophysiological findings in patients with Guillain-Barre´ syndrome Methods: We performed a retrospective analysis of 33 patients with GBS admitted to Dicle University Medical Faculty Hospital neurology clinic from January 2011 to March 2014. Were reviewed. Epidemiological, clinical, therapeutical and evolutionary data were collected. Results: Thirty-six patients with the diagnosis of GBS included 22 males and 14 females. The average age at diagnosis was 41.3±21.38years with a wide age range (11–82) and a peak between 36 and 55 years. Based on clinical and electrophysiological features, 61.1% of the patients had acute inflammatory demyelinating polyneuropathy (AIDP), 22.2% acute motor and sensory axonal neuropathy 11.1% had acute motor axonal neuropathy, and 5.6% had Miller Fisher Syndrome. In 28 of 36 patients (77.0%), potential trigger factors could be identified. Respiratory tract infection was the most common infection (36.1%), followed by gastrointestinal infection (27.8%), after surgery (11.1%), vaccination (2.8%) Conclusion: Our study showed that surgery may be triggered GBS and suggesting a geographical and environmental factor involved in GBS etiopathogenesis.

Keywords

• Guillain-Barre syndrome, clinical findings, surgery, geographical location

Guillain-Barre sendromunda klinik ve demografik özellikler

Abstract

Amaç: Guillain-Barre Sendrom'lu (GBS) hastaların epidemiyolojik, klinik, laboratuvar ve elektrofizyolojik bulguları değerlendirilmesi amaçladık. Yöntemler: Çalışmaya Güneydoğu Anadolu bölge nüfusunu temsil ettiği düşünülen Dicle üniversitesi tıp fakültesi hastanesi nöroloji kliniğine Ocak 2011 ve Mart 2014 yılları arasında başvurmuş ve yatırılarak takip edilen 36 olgunun dosya kayıtları geriye dönük olarak incelendi. Tüm hastaların demografik, klinik, laboratuar, BOS, elektrofizyolojik ve tedavi verileri kaydedildi. Bulgular: Guillain-Barre Sendromu tanısı alan 36 olgunun 22 (%61,1)\'u erkek ve 14 (%38,9)\'i kadındı. Klinik ve elektrofizyolojik verilerine göre 22 hasta (%61,1) Akut İnflamatuar Demiyelinizan Polinöropati (AIDP), 4 hasta (%11,1) Akut Motor Aksonal Nöropati (AMAN), 8 hasta (%22,2) Akut Motor ve Sensoryal Aksonal nöropati (AMSAN) ve 2 hasta (%5,6) Miller Fisher Sendromu (MFS) olarak değerlendirildi. Hastaların çoğunda öncül bir hastalık mevcuttu. 13 hastada (%36,1) üst solunum yolu enfeksiyonu (ÜSYE) , 10 hastada (%27,8) gastroenterit, 4 hastada(%11,1) cerrahi, bir hastada(%2,8) aşı öyküsü mevcuttu. Sonuç: Çalışmamız GBS'yi cerrahi işlemlerin tetikleyebileceğini ve GBS\'nin etyopatogenezinde coğrafyanın ve çevresel faktörlerin önemini göstermektedir.

Keywords

• Guillain-Barre sendromu, klinik bulgular, cerrahi, coğrafi bölge

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