Akneli hastalarda sistemik isotretinoin tedavisinin laboratuvar değişkenleri üzerine etkisi ve literatürün gözden geçirilmesi

Abstract

Amaç: İsotretinoin (İSO), bir sentetik retinoid olup konvansiyonel tedavilere yanıt vermeyen şiddetli kistik aknenin tedavisinde tercih edilen bir ilaçtır. Bu çalışmada oral İSO tedavisi başlanan akne hastalarında laboratuvar değerlerinin retrospektif olarak değerlendirilmesi amaçlanmıştır. Yöntemler: Çalışmaya dermatoloji polikliniğine başvuran ve klinik olarak akne tanısı konularak İSO tedavisi başlanan 40 hasta alındı. Hastaların tedavi öncesi ve tedavinin 3. ayındaki karaciğer fonksiyon testleri (AST, ALT), kan üre ve kreatinin değerleri ile total kolesterol, yüksek dansiteli lipoprotein (HDL), düşük dansiteli lipoprotein (LDL) ve trigliserid (TG) değerleri hasta dosyaları taranarak elde edildi. Bulgular: Hastaların tedavi öncesi ve tedavinin 3. ayındaki laboratuvar sonuçları karşılaştırıldığında total kolesterol, LDL, HDL, TG ve AST değerlerinde istatistiksel olarak anlamlı değişiklikler saptandı (p

Keywords

• Akne, isotretinoin, laboratuvar değişkenleri

Effect of systemic isotretinoin treatment on laboratory variables in patients with acne and a review of the literature

Abstract

Objective: Isotretinoin (ISO) is a synthetic retinoid that is a preferred drug for unresponsive to conventional therapy in the treatment of severe cystic acne. In this study, to evaluate retrospectively laboratory values in patients with acne using oral ISO treatment was aimed. Methods: 40 patients were enrolled to the study that admitted to the dermatology clinic and clinically diagnosed as acne vulgaris and oral isotretinoin treatment was started. Patient\'s pre-treatment and 3rd month of the teatment values of liver function tests (AST, ALT), blood urea nitrogen and creatinine levels, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) levels were obtained by screening of files. Results: Compared to values of patients before and 3rd month of treatment, statistically significant differences was detected for total cholesterol, LDL, HDL, TG and AST values (p

Keywords

• Acne, isotretinoin, laboratory variables

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