Prematür ejakülasyon tedavisinde güncel farmakolojik ajanlar

Abstract

Bu çalışmada prematür ejakülasyon (PE)\'un güncel medikal tedavisini gözden geçirmeyi ve değerlendirmeyi amaçladık. PE erkekleri en sık etkileyen seksüel rahatsızlıktır. Her yaş grubundaki erkekleri ve partnerlerinin yaşam kalitesini ciddi ölçüde etkileyebilir. PE için çeşitli tedaviler denenmektedir. Psikolojik tedavi PE hastaları için faydalı olabilmektedir. Lidokain veya lidokain-prilokain içeren çeşitli kremler PE tedavisinde kullanılmaktadır. Son zamanlarda serotonin geri alım inhibitörleri (SSRI) ejekülasyonu geciktirici yan etkilerinden dolayı ön plana çıkmıştır. SSRI\'ların birçok yan etkisi ve uzun süreli yarılanma ömürleri daha az yan etkisi olan ve potent formların geliştirilmesini gerektirmiştir. Yeni bir SSRI olan Dapoxetin ile yapılan çalışmalarda ümit verici sonuçlara ulaşılmıştır.

Keywords

• Prematür ejakülasyon, seratonin geri alım inhibitörleri

Current pharmacological agents for the treatment of premature ejaculation

Abstract

This study was aimed to review and assess the update studies regarding medical treatment for premature ejaculation (PE). It is the most common sexual problem affecting men. It can affect men at all ages and has a serious impact on the quality of life for men and their partners. A wide variety of therapeutic modalities have been tried for treatment of premature ejaculation. Psychological therapies may be helpful for patients with complaint PE. Several topical therapies have been used including lidocaine cream, lidocaine-prilocaine cream. There has been recent interest in the selective serotonin reuptake inhibitors (SSRI) for the treatment of PE, due to the fact that one of their common side effects is delayed ejaculation. Currently used SSRIs have several non-sexual side effects and long half lives, therefore there has been interest in developing a short acting, and efficacious SSRI that can be used on-demand for PE. Dapoxetine has been recently evaluated for the treatment of PE by several groups, and results so far appear promising.

Keywords

• premature ejaculation, selective serotonin re-uptake inhibitor, sexual problem

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