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The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism

Year 2014, , 244 - 256, 01.03.2014

Müzeyyen İzmirli Özgür Aldemir Bülent Gögebakan Davut Alptekin

https://doi.org/10.5798/diclemedj.0921.2014.01.0411
Cited By: 1

Abstract

5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folic acid metabolism. This protein\'s gene is mapped on chromosome 1, which is located at the end of the short arm (1p36.3). MTHFR enzyme plays a key role in cell metabolism including folic acid and nucleotide synthesis (DNA, RNA). Polymorphism is also a factor in biodiversity, and is different according to ethnic heritage and racial. The 677 C>T is also MTHFR polymorphisms that decrease MTHFR enzyme activity. The aim of this study is to compile studies are associated with MTHFR C677T polymorphism. PUBMED, Turk Biochemistry and Jornal of Clinical & Experimental Investigations were searched to develop an investigatory pursuit strategy. MTHFR, Turkish population, 677 C>T and polymorphisms were key words including “MTHFR”, “Türk popülasyonu: Turkish population”, “677 C>T” “polimorfizm: polymorphism” used to focus the search. The literature review included all published relevant Turkish population and MTHFR polymorphisms for that all of study. The data of selected polymorphism for Turkish population was listed in tables for easy access and retrieval.

Keywords

MTHFR Turkish population 677 C>T polymorphism

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The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism

Year 2014, , 244 - 256, 01.03.2014

Müzeyyen İzmirli Özgür Aldemir Bülent Gögebakan Davut Alptekin

https://doi.org/10.5798/diclemedj.0921.2014.01.0411
Cited By: 1

Abstract

5,10-Metilentetrahidrofolat redüktaz (MTHFR) folik asit metabolizması için en önemli enzimlerden biridir. Bu proteinin geni 1 numaralı kromozomun kısa kolunda (1p36.3) haritalanmıştır. MTHFR enzimi, folik asit, nükleotid sentezi (DNA, RNA) gibi pek çok reaksiyonu içeren hücre metabolizmasında, kilit rol oynar. Polimorfizmler etnik kökene ve ırklara göre farklılık gösteren ve biyoçeşitlilikte rol oynayan bir faktördür. MTHFR 677 C>T polimorfizmi enzim aktivitesini azaltan bir polimorfizmdir. Çalışmanın amacı, Türkiye\'de MTHFR C677T polimorfizmi ile ilgili olan çalışmaları derlemektir. Bu nedenle, Türkiye\'de yapılmış MTHFR 677 C>T polimorfizmi ile ilgili PUBMED, Türk Biyokimya ve Klinik & Deneysel Araştırmalar dergisinde yayınlanmış bütün çalışmalar derlenmiştir. Araştırma yapılırken “MTHFR”, “Türk popülasyonu: Turkish population”, “677 C>T” “polimorfizm: polymorphism” anahtar kelimeleri kullanılmıştır. Bu çalışmalar, belli başlı hastalık gruplarına göre sınıflandırılmış ve tablolar halinde okuyucunun değerlendirmesine sunulmuştur.

Keywords

MTHFR Türk populasyonu 677 C>T polimorfizmi

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There are 159 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Müzeyyen İzmirli This is me

Özgür Aldemir This is me

Bülent Gögebakan This is me

Davut Alptekin This is me

Publication Date March 1, 2014
Submission Date March 2, 2015
Published in Issue Year 2014

Cite

APA İzmirli, M., Aldemir, Ö., Gögebakan, B., Alptekin, D. (2014). The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. Dicle Tıp Dergisi, 41(1), 244-256. https://doi.org/10.5798/diclemedj.0921.2014.01.0411
AMA İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. March 2014;41(1):244-256. doi:10.5798/diclemedj.0921.2014.01.0411
Chicago İzmirli, Müzeyyen, Özgür Aldemir, Bülent Gögebakan, and Davut Alptekin. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Tıp Dergisi 41, no. 1 (March 2014): 244-56. https://doi.org/10.5798/diclemedj.0921.2014.01.0411.
EndNote İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D (March 1, 2014) The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. Dicle Tıp Dergisi 41 1 244–256.
IEEE M. İzmirli, Ö. Aldemir, B. Gögebakan, and D. Alptekin, “The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism”, diclemedj, vol. 41, no. 1, pp. 244–256, 2014, doi: 10.5798/diclemedj.0921.2014.01.0411.
ISNAD İzmirli, Müzeyyen et al. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Tıp Dergisi 41/1 (March 2014), 244-256. https://doi.org/10.5798/diclemedj.0921.2014.01.0411.
JAMA İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. 2014;41:244–256.
MLA İzmirli, Müzeyyen et al. “The Studies about Diseases Concerning With Contemplated MTHFR 677 C>T Polymorphism”. Dicle Tıp Dergisi, vol. 41, no. 1, 2014, pp. 244-56, doi:10.5798/diclemedj.0921.2014.01.0411.
Vancouver İzmirli M, Aldemir Ö, Gögebakan B, Alptekin D. The studies about diseases concerning with contemplated MTHFR 677 C>T polymorphism. diclemedj. 2014;41(1):244-56.

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https://doi.org/10.5798/dicletip.457243