Ocular findings in osteoporosis and rheumatismal diseases

Abstract

Osteoporosis and rheumatismal diseases have some findings that affecting all layers of the eye. Adult and Juvenile rheumatoid arthritis, Sjögren\'s syndrome and ancylosing spondylitis are frequently together with eye symptoms and signs. Eye findings frequently precede the symptoms of systemic disease. Uveitis, iridocyclitis, vitritis, keratitis, scleritis, anterior ischemic optic neuropathy and retinal vasculitis are the most frequent ocular inflammatory findings. Ocular inflammation may be either related to disease process itself, or secondary to anti-inflammatory agents. In present study, in the light of literature review, ocular findings of osteoporosis and rheumatismal diseases that most frequently accompanied by ocular signs were reviewed.

Keywords

• Osteoporosis, rheumatismal disease, ocular Finding

Osteoporoz ve romatizmal hastalıklarda göz bulguları

Abstract

Osteoporoz ve romatizmal hastalıklar gözün tüm tabakalarını etkileyen bulgular ile karşımıza çıkmaktadır. Erişkin ve Juvenil Romatoid Artrit, Sjögren Sendromu, Ankilozan Spondilit sıklıkla göz bulguları ile beraberlik gösteren romatizmal hastalıklardır. Göz bulguları sıklıkla sistemik hastalığın semptomlarına öncülük etmektedirler. Bu hastalıklarda en sık olarak üveit, iridosiklit, vitritis, keratit, sklerit, anterior iskemik optik nöropati ve retinal vaskülit gibi oküler inflamasyon bulguları görülmektedir. Oküler inflamasyon hastalığın kendisinden kaynaklanabileceği gibi bu hastalıkların tedavisinde kullanılan ilaçlara bağlı olarak da karşımıza çıkabilmektedir. Bu çalışmada osteoporoz ve en sık göz bulgusu izlenen romatizmal hastalıkların oküler bulguları literatür eşliğinde araştırıldı.

Keywords

• Ostoeporoz, romatizmal hastalık, göz bulgusu.

References

1. Hamideh F, Prete PE. Ophthalmologic manifestations of rheumatic diseases. Semin Arthritis Rheum 2001;30:217- 41.
2. Mbekani JN, Slamovits TL, Schwartz BH, Sauer HL. Ocu- lar inflammation associated with alendronate therapy. Arch Ophthalmol 1999;117:837-8.
3. Macarol V, Fraunfelder FT. Pamidronate disodium and pos- sible ocular adverse drug reactions. Am J Ophthalmol 1994;118:220-4.
4. Gong Y, Vikkula M. Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is as- signed to chromosome region 11 q12-13. Am J Hum Ge- net 1996;59:146-51.
5. SteichenpGersdorf E, Gassner I, Insim K, Sperl W. Persis- tent hyperplastic primary vitreous in a family with osteo- porosis-pseudoglioma syndrome. Clin Dysmorphol 1997;6:171-6.
6. De Paepe A, Leroy JG, Nuytinck L, Meire F, Capoen J. Os- teoporosis-psedoglioma syndrome. Am J Med Genet 1993;45:30-7.
7. Kotaniemi K, Aho K, Kotaniemi A. Uveitis as a cause of visual loss in arthritides and comparable conditions. J Rheumatol 2001 ;28:309-12.
8. Hajjaj-Hassouni N, Guedira N, Lazrak N, et al. Osteomala- cia as a presenting manifestation of Sjogren's syndrome. Rev Rhum 1995; 62:529-32.

9. Katayama I, Koyano T, Nishioka K. Prevalence of eyelid dermatitis in primary Sjogren's syndrome. Int J Dermatol 1994;33:421-4.
10. White P. Juvenile rheumatoid arthritis features. In: Rheu- matology. Klippel JH, Dieppe PA. Mosby, 1994, 112-114.
11. Dollfus H. Eye involvement in children's with rheumatic diseases. Baillieres Clin Rheumatol 1998;12:309-28.
12. Cassidy JT. Juvenile rheumatoid arthritis. In: Rheumatol- ogy. Kelley WN, Ruddy S, W.B.Saunders Co.5th. ed. 1997:1216.
13. Moller DE, Urban A, Kraft HE, Schontube M. Eye com- plications in 458 children with rheumatoid arthritis. Klin Monatsbl Augenheilkd 2000;217:15-22.
14. Reddy SC, Rao UR. Ocular complications of adult rheu- matoid arthritis. Rheumatol Int 1996;16:49-52.
15. Badelon I. Eye and spondylarthropathies. Rev Prat 1999;49:1995-8.
16. Peric S, Cerovski B, Peric P. Anterior ischaemic optic
17. neuropathy in patient with rheumatoid arthritis-case report. Coll Antropol 2001;25 :67-70.
18. Agildere AM, Tutar NU, Yucel E, Coskun M, Benli S, Aydin P. Pachymeningitis and optic neuritis in rheumatoid arthritis: MRI findings. Br J Radiol 1999;72:404-7.
19. Matsuo T, Matsuo N. Progressive subretinal fibrosis in pa- tients with rheumatoid arthritis and renal dysfunction. Ophthalmologica 1998;212:289-94.
20. Çevik R, Çakmak SS, Nas K ve ark. Romatoid artritli has- talarda göz tutulumu. Dicle Tıp Derg 2004;28:35-39.
21. Wenngren BI, Toolanen G, Hildingsson C. Oculomotor dysfunction in rheumatoid patients with upper cervical dislocation. Acta Otolaryngol 1998;118:609-12.
22. Panfilio CB, Hernandez-Cossio O, Hernandez-Fustes OJ. Orbital myositis and rheumatoid arthritis: case report. Arq Neuropsiquiatr 2000;58:174-7.
23. Costescu I, Vilciu A. Clinical observations of a case of an- terior uveitis associated with ankylosing spondylitis and psoriatic arthritis. Oftalmologia 1998;42:74-7.
24. Huppertz HI, Munchmeier D, Lieb W. Ocular manifesta- tions in children and adolescents with Lyme arthritis. Br J Ophthalmol 1999;83:1149-52.
25. Zaidman GW. The ocular manifestations of Lyme disease. Int Ophthalmol Clin 1997;37:13-28.