The role of the Syndrome X in the pathophysiology of sleep-apnea syndrome

Abstract

Objective: Syndrome X or microvascular angina pectoris is defined as angina pectoris due to coronary microvas­cular dysfunction in patients with non-stenotik epicardial arteries. The aim of his study was to investigate the re­lationship between obstructive sleep apnea syndrome (OSAS) and syndrome X. Materials and methods: Twenty patients (11 male, 9 fe­male) with the complaint of chest pain who referred to Cardiology Clinics of Dicle University were enrolled in the study as Group 1. All of the patients\' exercise tests were positive, epicardial coronary arteries were normal and coronary flows were slow in Group 1. Thirty healthy person were enrolled in the study as group 2. Polysom­nography (PSG) and echocardiography (ECHO) was per­formed in all patients. Results: In Group 1, 11 (55%) patients had obstructive sleep apnea. In Group 2, three patients (10%) had OSAS. There were significant differences in terms of OSAS fre­quency among groups. There were no significant differ­ences in terms of left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), left ven­tricular end diastolic diameter (LVEDD), stroke volume, deceleration time (DT) , ejection time (ET) and the left atrium (LA) diameter between Syndrome X and control groups according to echocardiographic examination (p>0.05). However, IVRT, RA diameter, the myocardial performance index (MPI), PAP, and MEV / mav rates were significantly different (p

Keywords

• Syndrome X, Obstructive sleep apnea syn­drome, Echocardiography.

Sendrom X fizyopatolojisinde uyku-apne sendromu\'nun rolü

Abstract

Amaç: Sendrom X veya mikrovasküler anjina pektoris, koroner anjiyografide, nonstenotik epikardiyal arterle­ri olan hastalarda, koroner mikrovasküler disfonksiyona bağlı gelişen anjina pektoris olarak tanımlanır. Bu ça­lışmada sendrom X ile obstüktif uyku apnesi sendromu (OSAS) arasındaki ilişki araştırılmıştır. Gereç ve yöntem: Bu çalışmaya Dicle Üniversitesi Tıp Fakültesi Kardiyoloji polikliniğine göğüs ağrısı nedeniyle başvuran ve efor testi pozitif olup koroner anjiyografisinde epikardiyal koroner arterleri normal veya yavaş koroner akım saptanan 20 hasta (11 erkek, 9 kadın) ile (Grup I) yapılan tetkiklerinde herhangi bir hastalık tespit edilme­miş 30 kişi (Grup II) dahil edildi. Hastalara polisomnografi (PSG) ve ekokardiyografi (EKO) uygulandı. Bulgular: Çalışmaya alınan hastalar iki ayrı gruba alındı. Grup 1; Kardiyak sendrom X tanılı 20 hasta, Grup 2; 30 sağlıklı birey. Her iki grubun kardiyak yapı ve fonksiyonla­rı ekokardiyografik olarak değerlendirildi. Grup I hastala­rın 11\'inde (%55) OSAS saptandı. Grup II hastalarda ise 3 olguda (%10) OSAS tespit edildi. Her iki grup arasın­da OSAS sıklığı bakımından anlamlı fark bulunmakta idi (p

Keywords

• Sendrom X, obstruktif uyku apne sendromu, ekokardiyografi.

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