Effect of the hematological and biochemical parameters on outcomes of the patients with infective endocarditis

Abstract

Objectives: This study was designed to examine hae­matological changes in infective endocarditis (IE) and the association between laboratory findings and mortality or complications including events in IE. Materials and methods: Forty-four patients who were hospitalized with a diagnosis of IE at the Department of Cardiology, Dicle University, Ataturk University and Harran University, from June 2007 to June 2011, were retrospec­tively evaluated. The diagnosis of IE was made clinically and was confirmed with Duke\'s criteria. The haematologi­cal and biochemical parameters were recorded. Results: Age, white blood cell count, neutrophil count, neutrophil lymphocyte ratio, mean platelet volume and complication rate (p

Keywords

• Infective endocarditis, mortality, haemato­logical changes, S.aureus

İnfektif endokarditin klinik sonuçları üzerine hematolojik ve biyokimyasal parametrelerin etkisi

Abstract

Amaç: Çalışmamızda İnfektif endokarditli (İE) hastalarda hematolojik parametrelerdeki değişiklikleri ve bu deği­şikliklerin komplikasyon ve mortalite oranları ile ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Dicle Üniversitesi, Atatürk Üniversi­tesi ve Harran Üniversitesi Tıp Fakültelerinin kardiyoloji bölümlerinde İE tanısı ile Haziran 2007 den Haziran 2011 tarihleri arasında yatırılan 44 hasta retrospektif olarak de­ğerlendirildi. İE tanısında Duke kriterleri esas alındı. He­matolojik ve biyokimyasal parametreler kaydedildi. Bulgular: Yaşayan hastalar ile karşılaştırıldığında, İE bağlı ölen hastalarda ortalama yaş, beyaz küre sayısı, nötrofil sayısı, ortalama trombosit hacmi ve komplikasyon oranı daha yüksek bulundu (sırasıyla, p

Keywords

• İnfektif endokardit, hematolojik deği­şiklikler, S.aureus, mortalite.

References

1. Horstkotte D, Follath F, Gutschik E et al. Guidelines on pre- vention, diagnosis and treatment of infective endocardi- tis executive summary; the task force on infective endo- carditis of the European society of cardiology. Eur Heart J 2004;25(3):267-6.
2. Hellgren U, Julander I. Are white blood cell count, platelet count, erythrocyte sedimentation rate and C-reactive pro- tein useful in the diagnosis of septicaemia and endocardi- tis? Scand J Infect Dis 1986 ;18(5):487-8.
3. Wallace SM, Walton BI, Kharbanda RK, Hardy R, Wilson AP, Swanton RH. Mortality from infective endocarditis: clinical predictors of outcome. Heart 2002;88(1):53-60.
4. Gunebakmaz O, Kaya MG, Kaya EG et al. Mean platelet vol- ume predicts embolic complications and prognosis in infec- tive endocarditis. Int J Infect Dis 2010;14(11):e982-5.
5. Van der Lelie J, Von dem Borne AK. Increased mean platelet volume in septicaemia. J Clin Pathol 1983 ;36(6):693-6.
6. Wangsomboonsiri W, Luksananun T, Saksornchai S, Ket- wong K, Sungkanuparph S. Streptococcus suis infection and risk factors for mortality. J Infect. 2008;57(5):392-6.
7. İnanç T, Kaya MG, Kaya EG ve ark. İnfektif endokardit: retrospektif olarak 27 hastanın değerlendirilmesi. TAD 2007;5(3):91-9.
8. Leblebicioglu H, Yilmaz H, Tasova Y et al. Characteristics and analysis of risk factors for mortality in infective endo- carditis. Eur J Epidemiol 2006;21(1):25-31.

9. Yavuz SS, Eren M, Yavuz A ve ark. İnfektif Endokardit: 58 olgunun değerlendirilmesi. Klimik Dergisi 2003;16(2):55- 62.
10. Whitby M, Fenech A. Infective endocarditis in adults in Glasgow, 1976-81. Int J Cardiol 1985;7(4):391-403.
11. Durack DT, Lukes AS, Bright DK. New criteria for diagno- sis of infective endocarditis: utilization of specific echocar- diographic findings. Duke Endocarditis Service. Am J Med 1994 ;96(3):200-9.
12. Heiro M, Helenius H, Sundell J et al. Utility of serum C- reactive protein in assessing the outcome of infective endo- carditis. Eur Heart J 2005 ;26(18):1873-81.
13. Hogevik H, Olaison L, Andersson R, Alestig K. C-reactive protein is more sensitive than erythrocyte sedimentation rate for diagnosis of infective endocarditis. Infection 1997 ;25(2):82-5.
14. Lancellotti P, Galiuto L, Albert A, Soyeur D, Pierard LA. Relative value of clinical and transesophageal echocardio- graphic variables for risk stratification in patients with in- fective endocarditis. Clin Cardiol 1998 ;21(8): 572-8.
15. Ako J, Ikari Y, Hatori M, Hara K, Ouchi Y. Changing spec- trum of infective endocarditis: review of 194 episodes over 20 years. Circ J 2003 ;67(1): 3-7.
16. Chu VH, Cabell CH, Benjamin DK Jr et al. Early predictors of in-hospital death in infective endocarditis. Circulation 2004; 109(14): 1745-9.