Levels of endocrine hormones and lipids in male patients with carpal tunnel syndrome

Year 2011, , 427 - 431, 01.12.2011

Hülya Uzkeser Saliha Karatay Meltem Alkan Melikoğlu

https://doi.org/10.5798/diclemedj.0921.2011.04.0061

Abstract

Objectives: This study was performed to evaluate the re­lationship between endocrine hormones, lipid levels and clinical parameters in male patients with carpal tunnel syndrome (CTS). Materials and methods: Fifteen male patients with CTS and 16 healthy controls were included in the study. Serum free T3, free T4, thyroid-stimulating hormone (TSH), free testosterone, dehydroepiandrosterone sulfate, triglycer­ide and total cholesterol levels were analyzed. Symptom severity and hand function were assessed using the Bos­ton Carpal Tunnel Questionnaire in clinical examination. Results: Serum free T3, free T4, TSH, free testosterone, dehydroepiandrosterone sulfate, triglyceride and total cholesterol levels were similar between CTS patients and controls (p> 0.05). Also, there was no statistically signifi­cant correlation between laboratory parameters and clini­cal characteristics in patients with CTS (p> 0.05). Conclusion: The serum free T3, free T4, TSH, free tes­tosterone, dehydroepiandrosterone sulfate, triglyceride and total cholesterol levels seem within normal range in male CTS patients. Further studies are needed to inves­tigate association endocrine factors, lipid levels such as triglyceride and total cholesterol with CTS in male and fe­male patients.

Keywords

Carpal tunnel syndrome, thyroid hormone, testosterone, lipid levels

Karpal tünel sendromlu erkek hastalarda endokrin hormon ve lipid seviyeleri

Abstract

Amaç: Bu çalışma karpal tünel sendromlu (KTS) erkek hastalarda endokrin hormon ve lipid düzeyleriyle klinik özellikler arasındaki ilişkiyi belirlemek amacıyla düzen­lendi. Gereç ve yöntem: Çalışmaya 15 erkek KTS hastası ve 16 sağlıklı kontrol dahil edildi. Serum serbest T3, serbest T4, tiroid stimüle edici hormon (TSH), serbest testosteron, dehidroepiandrosteron sülfat, trigliserid ve total kolesterol düzeyleri analiz edildi. Klinik değerlendirmede semptom şiddeti ve el fonksiyonları Boston Karpal Tünel Anketi ile belirlendi. Bulgular: Karpal tünel sendromu hastalarında serum serbest T3, serbest T4, TSH, serbest testosteron, dehid­roepiandrosteron sülfat, trigliserid ve total kolesterol de­ğerleri kontrollerle benzer düzeylerdeydi (p> 0.05). KTS hastalarında klinik özellikler ile laboratuar parametreleri arasında da istatistiksel olarak anlamlı bir korelasyon yok­tu (p> 0.05). Sonuç: Karpal tünel sendromu olan erkek hastalarda serum serbest T3, serbest T4, TSH, serbest testosteron, dehidroepiandrosteron sülfat, trigliserid ve total kolesterol düzeyleri normal aralıkta görülmektedir. Kadın ve erkek hastalarda total kolesterol ve trigliserid gibi lipid düzeyleri ve endokrin faktörler ile KTS arasındaki ilişkiyi araştıracak yeni çalışmaların yapılması gerekmektedir.

Keywords

Karpal tünel sendromu, tiroid hormo­nu, testosteron, lipid düzeyleri

References

• Ibrahim T, Majid I, Clarke M, Kershaw CJ. Outcome of car- pal tunnel decompression: the influence of age, gender, and occupation. Int Orthop 2009; 33 (5):1305-9.
• Werner RA, Andary M. Carpal tunnel syndrome: pathophysi- ology and clinical neurophysiology. Clin Neurophysiol 2002; 113 (9):1373-81
• Aszalós Z. Some neurological and psychiatric complications of the disorders of the hypothalamo-hypophyseal system. Orv Hetil 2007; 148 (16):723-30.
• Aszalós Z. Some neurologic and psychiatric complications in endocrine disorders: the thyroid gland. Orv Hetil. 2007; 148 (7):303-10
• Nakamichi K, Tachibana S. Hypercholesterolemia as a risk factor for idiopathic carpal tunnel syndrome. Muscle Nerve 2005 Sep;32(3):364-7.
• Bischoff C, Isenberg C, Conrad B.Lack of hyperlipidemia in carpal tunnel syndrome. Eur Neurol 1991;31(1):33-5.
• Mondelli M, Aprile I, Ballerini M, et al. Sex differences in carpal tunnel syndrome: comparison of surgical and non- surgical populations. Eur J Neurol 2005; 12 (12):976-83.
• Stevens JC. AAEE minimonograph 26: the electrodiagnosis of carpal tunnel syndrome. American Association of Elec- trodiagnostic Medicine. Muscle Nerve 1997; 20 (12):1477- 86.
• Levine DW, Simmons BP, Koris MJ, et al. A self-adminis- tered questionnaire for the assessment of severity of symp- toms and functional status in carpal tunnel syndrome. J Bone Joint Surg Am 1993; 75 (11):1585-92
• Sezgin M, Incel NA, Serhan S Camdeviren H, As I, Erdoğan C. Assessment of symptom severity and functional status in patients with carpal tunnel syndrome: reliability and func- tionality of the Turkish version of the Boston Question- naire. Disabil Rehabil 2006; 28 (20):1281-6.
• van Dijk MA, Reitsma JB, Fischer JC, Sanders GT. Indica- tions for requesting laboratory tests for concurrent diseases in patients with carpal tunnel syndrome: a systematic re- view. Clin Chem 2003; 49 (9):1437-44.
• Bahou YG. Carpal tunnel syndrome: a series observed at Jordan University Hospital (JUH), June 1999-December 2000. Clin Neurol Neurosurg. 2002; 104 (1):49-53.
• Moghtaderi A, Izadi S, Sharafadinzadeh N. An evaluation of gender, body mass index, wrist circumference and wrist ratio as independent risk factors for carpal tunnel syndrome. Acta Neurol Scand 2005; 112 (6):375-9.
• Becker J, Nora DB, Gomes I, et al. An evaluation of gender, obesity, age and diabetes mellitus as risk factors for carpal tunnel syndrome. Clin Neurophysiol 2002; 113 (9):1429- 34.
• Kouyoumdjian JA, Morita MD, Rocha PR, Miranda RC, Gouveia GM. Body mass index and carpal tunnel syn- drome. Arq Neuropsiquiatr. 2000; 58 (2A): 252-6.
• Padua L, Padua R, Aprile I, Tonali P. Italian multicentre study of carpal tunnel syndrome. Differences in the clinical and neurophysiological features between male and female patients. J Hand Surg Br 1999; 24 (5): 579-82.
• Hobby JL, Venkatesh R, Motkur P. The effect of age and gender upon symptoms and surgical outcomes in carpal tunnel syndrome. J Hand Surg Br 2005; 30 (6):599-604.
• Ferry S, Hannaford P, Warskyj M, Lewis M, Croft P. Carpal tunnel syndrome: a nested case-control study of risk factors in women. Am J Epidemiol 2000; 151 (6):566-74.
• Vessey MP, Villard-Mackintosh L, Yeates D. Epidemiology of carpal tunnel syndrome in women of childbearing age. Findings in a large cohort study. Int J Epidemiol 1990; 19 (3):655-9.
• Ablove RH, Ablove TS. Prevalence of carpal tunnel syn- drome in pregnant women. WMJ 2009; 108 (4):194-6.
• Duyff RF, Van den Bosch J, Laman DM, van Loon BJ, Lins- sen WH. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study. J Neurol Neurosurg Psychiatry 2000; 68 (6):750-5.
• Yerdelen D, Ertorer E, Koç F. The effects of hypothyroid- ism on strength-duration properties of peripheral nerve. J Neurol Sci 2010; 294 (1-2):89-91.
• Cruz MW, Tendrich M, Vaisman M, Novis SA. Electroneu- romyography and neuromuscular findings in 16 primary hypothyroidism patients. Arq Neuropsiquiatr 1996; 54 (1):12-8.