Farelerde lornoksikam ile parasetamol\'ün preemptif analjezik etkinliğinin karşılaştırılması

Abstract

Amaç: Preemptif analjezi, ağrılı uyarıdan önce bir anal­jezik rejiminin uygulanarak periferik ve santral nosisep­siyonun bloke edilmesi anlamına gelmektedir. Biz bu deneysel çalışmamızda fareler üzerinde parasetamol ile lornoksikamın preemptif analjezik özelliklerini karşılaştır­mayı amaçladık. Gereç ve yöntem: Fareler üç gruba ayrıldı. Farelerin sağ ön ayağına formalin enjeksiyonundan önce birinci gruba intraperitoneal serum fizyolojik, ikinci gruba lornoksikam ve üçüncü gruba parasetamol enjekte edildi. İşlem sonra­sı 60 dk boyunca farelerin ağrı cevabı kaydedildi. Bulgular: İlk 10 dk\'da lornoksikamın kontrol grubuna göre daha etkin olduğu görünürken, 11-60.dk ve 0-60. dk dikkate alındığında parasetamolün lornoksikamdan ve kontrol grubundan daha etkin bir analjezi sağladığı gö­rülmüştür. Sonuç: Çalışmamızda akut fazda lornoksikamın parase­tamole göre anlamlı fayda sağlamasına karşın tonik fazda ve toplam sürede parasetamol daha etkin bulunmuştur.

Keywords

• Preemptif analjezi, lornoksikam, pa­rasetamol, fare

The Comparison of efficacy of lornoxicam and paracetamol for preemptive analgesia in mice

Abstract

Objectives: Preemptive analgesia means that block the peripheral and central nociception as an analgesic regime apply before the painful stimulus. We aimed compared preemptive analgesic properties of lornoxicam with par­acetamol on mice in this experimental study. Materials and methods: Experimental mice were divided into three groups. Before the formalin injection in the right front foot of mice, saline administered in first group, lor­noxicam administered in second group and paracetamol in third group intraperitoneally. Responses to pain of mice were recorded after the procedure during the 60 min. Results: While appears to be lornoxicam more effective than the control group in the first 10 minutes, paracetamol provided more effective analgesia lornoxicam and control group within 11-60th min. and 0-60th min. Conclusion: Although lornoxicam provided significant benefit in acute phase, paracetamol was found more ef­fective in tonic phase and total time in this study.

Keywords

• Preemptive, analgesia, lornoxicam, parac­etamol, mice

References

1. Dahl JB, Kehlet H. The value of pre-emptive analge- sia in the treatment of postoperative pain. Br J Anaesth 1993;70(4):434-9.
2. Wall PD. The prevention of postoperative pain. Pain 1988;33(3):289-90.
3. Rosenow DE, Albrechtsen M, Stolke D. A comparison of pa- tient controlled analgesia with lornoxicarn versus morphine in patients undergoing lumber disk surgery. Anesth Analg 1998; 86(10):1045-50.
4. Sener M, Yilmazer C, Yilmaz I, Caliskan E, Donmez A, Ar- slan G. Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhi- noplasty: a prospective, randomized, double-blind, placebo- controlled study. Eur J Anaesthesiol 2008; 25(2):177-82.
5. Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A. Bioequivalence study comparing a new parac- etamol solution for injection and propacetamol after single intravenous infusion in healthy subjects. Int J Clin Pharma- col Ther 2004;42(1):50-7.
6. Shibata M, Ohkubo T, Takashi H, Inoki R. Modified forma- lin test, characteristic biphasic pain response. Pain 1989; 38(3):347-52.
7. Li GY, Yang BX, Liu H. Analgesic actions after local periph- eral administration of Lornoxicam in a model of formalin test in the rat. Sichuan Da Xue Xue Bao Yi Xue Ban 2005; 36(6): 703-5.
8. Woolf CJ, Chong MS. Preemptive analgesia treating postop- ertive pain by preventing the establishment of central sensi- tization. Anest Analg 1993;77:362-79.

9. Campbell WB. Lipid-drived autocoids: eicosanoids and plateled activating factor. In: Goodman AG, Roll TW,.Neis AS, Taylor P edds. Goodman and Gilman’s the pharmaco- logical basis of therapeutics, eight (international) edition. New York Mc Grow-Hill, 1991: 600-617.
10. Abbott FV, Ocvirk R, Najafee R, Franklin KB. Improving the efficiency of the formalin test. Pain 1999;83(5):561-9.
11. Arici S, Gurbet A, Turker G, Yavaşcaoglu B, Sahin S. Pre- emptive analgesic effects of intravenous paracetamol in to- tal abdominal hysterectomy. Agri. 2009;21(1):54-61.
12. Kokhno VN, Shmerko PS, Shakhtarin IIu. Impact of pre- emptive analgesia on postoperative pain syndrome in lap- aroscopic surgery. Anesteziol Reanimatol 2009;6(1):68-70.
13. Liu ZF, Wang XJ, Wang XC, Zhu L, Qiao Q. Clinical study of preoperative analgesia for liposuction. Zhonghua Zheng Xing Wai Ke Za Zhi 2007;23(2):128-9.
14. Borisov DB, Levin AV, Vyl’iurov IV, Sokolov AV, Nedashk- ovski Ä EV. Efficiency of preemptive intravenous paraceta- mol analgesia in abdominal surgery. Anesteziol Reanimatol 2007;5(1):38-40.
15. Toygar P, Akkaya T, Ozkan D, Ozel O, Uslu E Does iv par- acetamol have preemptive analgesic effect on lumber disc surgeries? Agri 2008;20(1):14-9.
16. Bruno E.Porcellini A, Farronato GP, et al. II dolore post- estrattivo. Trattamento analgesico con piroxicam. Dental Cadmos 1987;14(1):61-8.
17. Marcucci M.Panelli G.Cambini S. Clinical experience in the treatment of dental pain. Clin J Pain 1991;75:72-76
18. Yegül İ. Ağrı ve tedavisi, 1993, s1-15.
19. Yücel A, Özyalçm S. Çocukluk çağında ağrı, 2002; s17-9
20. Hein A, Norlander C, Blom L, Jakobsson J. Is pain pro- phylaxis in minor gynaecological surgery of clinical value? a double-blind placebo controlled study of paracetamol 1 g versus lornoxicam 8 mg given orally. Ambul Surg 2001;9(1):91-4.
21. Akcali GE, Iskender A, Demiraran Y, Kayikci A, Yalcin GS, Cam K, Balcioglu YO. Randomized comparison of efficacy of paracetamol, lornoxicam, and tramadol repre- senting three different groups of analgesics for pain con- trol in extracorporeal shockwave lithotripsy. J Endourol 2010;24(5):615-20.
22. Raj P, Prithvi A. Ağrı taksonomisi, Editor. Erdine S, Ağrı, 2000; s12-9.
23. Özyalçın S. Preemptif analjezi. Ağrı Dergisi 1998;7(1):5- 10.