Short and long term outcomes of primary angioplasty in patients aged 75 years and over

Abstract

Objectives: The treatment of elderly patients with ST segment elevated myocardial infarction (STEMI) remains controversial. This study aimed to investigate the effects of primary angioplasty in elderly patients on in-hospital and long term major adverse cardiac events (MACE). Materials and methods: From October 2003 to March 2008, we retrospectively enrolled 220 patients aged 75 years and over with STEMI who underwent primary an­gioplasty. Patients\' characteristics, in-hospital and long term events were recorded. Results: Male/Female ratio of patients was 129/91 and mean age was 78.7 ± 3.6 (range, 75-97) years, and 58.6% of male). Of these patients 29.2% were diabetics, 69.8% were hypertensive, 34.4% were smoker and 43.5% were anemic at admission. Anterior myocardial infarction was diagnosed in 52.3% of patients. Mean pain-balloon time was 222 ± 116 minutes. Eighty two (38.2%) of these 220 patients had three-vessel disease and 12 (5.7%) were diagnosed as cardiogenic shock. Procedural success was observed in 79.6% of patients. Heart failure was ob­served 27.7% in hospital and intra aortic pump was used in 14.5% of patients. There was no significant difference between age groups in long term major cardiac events and in hospital mortality. Diabetes, leukocyte count at admission and in hospital heart failure were independent predictors of short term MACE and low hemoglobin level at admission and peak CKMB levels were independent predictors of long term MACE. Conclusions: Primary angioplasty in patients aged 75 years and over seems to be associated with low proce­dural complication, high procedural success, improved short and long term survival.

Keywords

• Primary angioplasty, ST segment elevation, myocardial infarction, elderly patients, major adverse car­diac events

Primer anjiyoplastinin 75 yaş ve üstü hastalarda kısa ve uzun dönem sonuçları

Abstract

Amaç: ST-segment yükselmeli miyokart infarktüsü (STY­Mİ) ile başvuran yaşlı hastalarda tedavi konusunda çe­lişkiler mevcuttru. Bu çalışmanın amacı, primer perkütan koroner girişimin (PKG) yaşlı hastalarda, hastane içi ve uzun dönem ters kardiyak olaylar üzerine etkisini araş­tırmaktır. Gereç ve yöntem: Ekim 2003 ile Mart 2008 tarihleri ara­sında primer PKG uygulanan, STYMİ olan 75 yaş ve üstü 220 hasta geriye dönük olarak araştırıldı. Hasta özellikle­ri, hastane içi ve uzun dönem olaylar kaydedildi. Bulgular: Hastaların erkek/kadın oranı 129/91 yaş ortala­ması 78.7 ± 3.6 yıl (aralık, 75-97) idi. Hastaların %29.2\' sin­de diyabet, %69.8\' inde hipertansiyon, %34.4\' ünde siga­ra kullanımı, %43.5\'inde başvuru anında anemi mevcuttu. Hastaların %52.3\'ünde anteriyor miyokard infarktüsü (Mİ) mevcuttu. Ortalama ağrı-balon süresi 222 ± 166 dakika idi. Hastaların%38.2\'sinde üç damar hastalığı, %5.7\'sinde başvuru anında kardiyojenik şok mevcuttu. Tüm hastala­ra ayrım yapılmaksızın primer PKG yapıldı ve işlem başa­rısı %79.6 olarak bulundu. Hastaların %79\'una stent ta­kıldı. Hastane içi kalp yetersizliği hastaların %27.7\'sinde mevcuttu. İntra-Aortik Balon Pump %14.5\'inde kullanıldı. Farklı yaş gruplarındaki hastalar arasında hastane içi ve uzun dönem Major Kardiyak Olumsuz Olay (MKOO) açı­sından fark gözlenmedi. Hastaların %20.9\'unda hastane içi MKOO gözlendi. Diyabet, başvuru anı lölosit sayısı ve hastane içi konjestif kalp yetersizliği olması hastane içi MKOO\'ın bağımsız belirleyicileri idi. Ortalama bir yıl takibi yapılan hastaların (0-53 ay) %28\' inde MKOO gözlendi. Başvuru sırasındaki hemoglobin düşüklüğü ve doruk–CKMB düzeyi uzun dönem takipte MKOO\'nun bağımsız belirleyiciler olarak bulundu. Sonuç: Primer anjiyoplasti STYMİ ile başvuran 75 yaş ve üzeri hastalarda düşük işlem komplikasyon insidansı, yüksek işlem başarısı, yüksek kısa ve uzun dönem sağ kalım ile birlikte görünmektedir.

Keywords

• primer anjiyoplasti, ST segment yük­selmesi, miyokard infarktüsü, yaşlı hastalar, major kardi­yak olumsuz olay

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