Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease
Abstract
Objectives: Osteoporosis is commonly developed due to
natural course of Behçet’s disease (BD) and therapeutic
agents. It was aimed to investigate levels of osteoprotegerin
and TNF-α (tumor necrosis factor), and bone mineral density
(BMD) and correlation between them in BD.
Materials and methods: The study included two groups
as the study and the control group. Serum levels of TNF-α,
osteoprotegerin, osteocalcine, erythrocyte sedimentation rate
(ESR), C-reactive protein (CRP), and urinary creatinine and
deoxypyridinoline along with BMD level were evaluated and
compared. Correlation between TNF-α and osteoprotegerin
level was investigated.
Results: The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and
41.66±70.99, in the study and control groups, respectively.
There was no significant difference in body mass index
(BMI) of subjects between groups (p>0.05). Level of TNF-α
(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine
(p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in
BD patients, but the difference was not significant (p>0.05).
Urinary deoxypyridinoline/ urinary creatinine ratio in patients
with BD was significantly higher than those in control group
(p=0.030). Patients had significantly lower BMD comparfed
to the control group, except L2-L4 vertebral area (p<0.001,
p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and
p=0.111, respectively). No correlation was found between
TNF-α and osteoprotegerin.
Conclusions: The present study indicated that TNF-α and
BMD was negatively correlated with each other and TNF-α
had an effect on osteoporotic process in patients with BD.
Osteoprotegerin level was not decreased, and not correlated
with TNF-α.
Abstract
Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya
da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir.
Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-α) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır.
Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol
grubu olarak iki grup alındı. TNF-α, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi
(KMD) ölçüldü ve iki grup karşılaştırıldı.
Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36
hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.26±11.64 ve 41.66±70.99 bulundu. Vücut
kitle indeksi yönünden iki grup arasında fark bulunmadı.
TNF-α (p<0.001), deokspiridinolin (p<0.001) ve osteokalsin (p=0.041) düzeyleri kontrol grubundan önemli oranda
yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda
düşüktü ancak anlamlı düzeyde değildi (p>0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p=0.03). Hasta grubun
KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı
oranda düşüktü (sırasıyla p<0.001, p<0.001, p=0.035,
p<0.001, p=0.012, p<0.001, p<0.001 ve p=0.111). TNF-α
ve osteoprotegerin arasında korelasyon saptanmadı.
Sonuç: Bu çalışmada TNF-α ve KMD arasında negatif
korelasyon saptandı ve TNF-α’nın, BH’da osteoporotik
süreci etkilediği bulundu. Osteoprotogerin düzeyi düşüklüğü anlamlı değildi ve TNF-α ile korele değildi.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 1, 2012 |
| Submission Date | March 2, 2015 |
| Published in Issue | Year 2012 |