Lectin-like oxidized low density lipoprotein receptor 1(LOX-1) levels and endothelial dysfunction in patients with primary essential hyperhidrosis

Abstract

Objective: Primary essential hyperhidrosis (PEH) is a disorder characterized by excessive sweating of palms, soles and axilla. Although its etiology was not fully understand, increased activity of the autonomic nervous system may play a role in the pathogenesis of PEH. In the study we aimed to investigate flow mediated dilatation and lectin like oxide LDL receptor 1 (LOX-1) levels as an indicator of endothelial dysfunction in patient with PEH. Methods: Thirty-three PEH patients diagnosed with starch-iodine test and age- and sex-matched 19 healthy controls were included in the study. Flow-mediated dilatation was performed by ultrasonographical measurement of brachial artery. Serum LOX-1 levels were analyzed with Enzyme-Linked Immuno-Sorbent Assay (ELISA) kit. Results: Brachial artery FMD diameters and post-nitrate dilatation diameters were not different between patients and the controls. There was no difference between patient and control groups when compared for LOX-1 levels. Conclusion: Larger studies are needed to understand, indeed, whether excessive hyperhidrosis in PEH is only a peripheral excessive response to normal sympathetic activity or a systemic sympathetic hyperactivity with cardiovascular effects, which is disguised by compensatory mechanisms, such as nitric oxide (NO).

Keywords

• endothelial dysfunction, flow mediated dilatation, lectin like oxidized low density lipoprotein receptor 1, primary essential hyperhidrosis

Primer esansiyel hiperhidroz hastalarında lektin benzeri okside düşük dansiteli lipoprotein reseptör 1(LOX-1) düzeyleri ve endotel disfonksiyonu

Abstract

Amaç: Primer esansiyel hiperhidroz avuç içi ayak tabanı ve aksiler bölgenin aşırı terlemesi ile karakterize bir hastalıktır. Etyolojisi henüz açıklığa kavuşmamış olmakla beraber otonom sinir sisteminin artmış aktivitesinin rolü tartışılmaktadır. Biz bu çalışmada primer esansiyel hiperhidroz hastalarında akım aracılı dilatasyon ve lektin benzeri okside düşük dansiteli lipoprotein reseptör 1 düzeylerini inceleyerek endotelyal disfonfonksiyonun varlığını araştırmayı amaçladık. Yöntemler: Tanısı nişasta iyot testi ile konmuş otuzüç primer esansiyel hiperhidroz hastası ile 19 yaş ve cinsiyet uyumlu kontrol bu çalışmaya dahil edildi. Akım aracılı dilatasyon ultrasonografik olarak brakiyel arterden ölçüldü. Serum LOX-1 seviyeleri Enzim-Bağlı İmmun Sorbent Testi (ELISA) ile ölçüldü. Bulgular: Brakiyel arter akım aracılı dilatasyon çapları ve post nitrat dilatasyon çapları hasta ve kontrol grubu için istatistiksel olarak farklı değildi. LOX-1 değerleri açısından karşılaştırıldığında da hasta ve kontrol grubu arasında istatistiksel olarak fark yoktu. Sonuç: Primer esansiyel hiperhidrozda aşırı terleme erkin bezlerin normal sempatik aktiviteye verdiği aşırı bir periferik yanıt mı yoksa kardiyovasküler etkileri nitrik oksit ile maskelenmiş sistemik sempatik bir hiperaktivite mi olduğunu anlamak için daha geniş çalışmalara ihtiyaç vardır.

Keywords

• Endotel disfonksiyon, akım aracılı dilatasyon, lektin benzeri okside düşük dansiteli lipoprotein reseptör 1, primer esansiyel hiperhidroz

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