The relationship between subclinic atherosclerosis and red cell distribution width in patients with metabolic syndrome

Year 2013, Volume: 40 Issue: 4, 579 - 584, 01.12.2013

Ali Rıza Gülcan Mustafa Serkan Karakaş Barış Akdemir Mustafa Uçar Refik Emre Altekin Hüseyin Yılmaz

https://doi.org/10.5798/diclemedj.0921.2013.04.0336

Abstract

Objectıve: We have investigated the possible association between red cell distribution width (RDW) and subclinic atherosclerosis which can assessed by carotid intima-media thickness (CIMT) measurement in patients with metabolic syndrome (MetS). Methods: 74 patients with MetS were enrolled to the study. Patients were divided into 2 groups according to carotid intima-media thickness (CIMT) measurement: 35 patients with CIMT≥1.0 mm were at group 1 and 39 patients with CIMT

Keywords

red cell distribution width , metabolic syndrome , complete blood count

Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi

Abstract

Amaç: Çalışmamızda Metabolik sendrom (MetS)\'lu hastalarda karotis intima-media kalınlığı (KİMK) ölçümü ile değerlendirilen subklinik ateroskleroz ile eritrosit dağılım genişliği (EDG) arasında ilişki olup olmadığını araştırdık Yöntemler: Çalışmaya MetS\'lu 74 hasta alındı. Hastalar KİMK ölçümüne göre, KİMK≥1,0 mm olan 35 hasta grup 1, KİMK

Keywords

eritrosit dağılım genişliği , metabolik sendrom , total kan sayımı

References

• Reaven G. Insulin resistance, compensatory hyperinsu- linemia and coronary heart disease: Syndrome X revisited. In Jefferson LS, Cherrington AD, eds. Handbook of Physi- ology, Section 7, The Endocrine System, Vol II, The Pan- creas and Regulation of Metabolism. New York: Oxford University Press, 2001, pp 1169–1197.
• Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a sys- tematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49:403-414.
• Despres JP, Lamarche B, Mauriege P. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996;334:952–957.
• Perkins SL. Examination of blood and bone marrow. In: Greer JP, Foerster J, Lukens JN, et al. eds. Wintrobe’s Clin- ical Hematology. 11th ed. Salt Lake City, UT: Lippincott Williams & Wilkins; 2003:5-25.
• Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol 2010;105:312-317.
• van Kimmenade RR, Mohammed AA, Uthamalingam S, et al. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail 2010;12:129-136.
• Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40-47.
• Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163- 168.
• Ye Z, Smith C, Kullo IJ. Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease. Am J Cardiol 2011;107:1241-1245.
• Zorlu A, Bektasoglu G, Guven FM, et al. Usefulness of ad- mission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol 2012; 109:128-134.
• Patel KV, Ferrucci L, Ershler WB, et al. Red blood cell dis- tribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009;169:515-523.
• Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-1023.
• Lippi G, Targher G, Montagnana M, et al. Relation between red blood cell distribution width and inflammatory bio- markers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-632.
• Mallika V, Goswarni B, Rajappa M. Atherosclerosis pathophsiology and role of novel risk factors: a clinicobio- chemical perspective.Angiology 2007:58;513-522.
• Sinha AK, Eigenbrodt M, Mehta JL.Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol 2002:17;526-530.
• Mukherjee D, Yadav JS. Carotid artery intima-medial thick- ness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J 2002;144: 753-759.
• International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Avaliable at: http://www.idf.org/webdata/docs/IDF_Metasyndrome_ def .pdf Accessed October 4, 2005.
• Özgen AG. Metabolik sendrom ve dislipidemi. Türkiye Kli- nikleri J Int Med Sci 2006;2:43-54.
• Golden SH, Folsom AR, Coresh J, et al. Risk Factor Group- ings Related to Insulin Resistance and Their Synergistic Effects on Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities Study. Diabetes 2002;51:3069-3076.
• Hassinen M, Komulainen P, Lakka TA, et al. Metabolic Syn- drome and the Progression of Carotid Intima-Media Thick- ness in Elderly Women. Arch Intern Med 2006;166:444- 449.
• Kuller L, Borhani N, Furberg C, et al. Prevalence of sub- clinical atherosclerosis and cardiovascular disease and as- sociation with risk factors in the Cardiovascular Health Study. Am J Epidemiol 1994;139:1164-1179.
• Lament D. Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: Lifecourse study. BJM 2000;320:273-278.
• Androulakis AE, Andrikopoulos GK, Richter DJ, et al. The role of carotid atherosclerosis in the distinction between ischaemic and non-ischaemic cardiomyopathy. Eur Heart J 2000;21:919-926.
• Bots ML, Baldassarre D, Simon A, et al. Carotid intima-me- dia thickness and coronary atherosclerosis: weak or strong relations? European Heart Journal 2007;28:398-406.
• Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study. 1987-1993. Am J Epidemiol 1997;146:483-494.
• Zalawadiya SK, Veeranna V, Niraj A, et al. Red cell distri- bution width and risk of coronary heart disease events. Am J Cardiol 2010;106:988–993.
• Fukuta H, Ohte N, Mukai S, et al. Elevated plasma levels of B-type natriuretic peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J 2009;50:301-312.
• Libby P, Ridker PM, Maseri A. Inflammation and athero- sclerosis. Circulation 2002;105:1135–1143.
• Allen LA, Felker GM, Mehra MR, et al. Validation and po- tential mechanisms of red cell distribution width as a prog- nostic marker in heart failure. J Card Fail 2010;16:230–238.
• Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103–108.
• Cavusoglu E, Chopra V, Gupta A, et al. Relation between red blood cell distribution width (RDW) and all-cause mor- tality at two years in an unselected population referred for coronary angiography. Int J Cardiol 2010;141:141–146.
• Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006;47:19-31.
• Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr 2010;29:600-604.
• Kishi T, Hirooka Y. Sympathoexcitation associated with renin-angiotensin system in metabolic syndrome. Interna- tional Journal of Hypertension Epub 2013 Feb 13.
• Akin F, Köse N, Ayça B, et al. Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction. Angiology 2013;64:592-596.
• Sánchez-Chaparro MA, Calvo-Bonacho E, González-Quin- tela A. Ibermutuamur Cardiovascular RIsk Assessment Study Group. Higher red blood cell distribution width is associated with the metabolic syndrome: results of the Iber- mutuamur Cardiovascular RIsk assessment study. Diabetes Care 2010;33:40.
• Vayá A, Carmona P, Badia N, et al. Association between high red blood cell distribution width and metabolic syn- drome. Influence of abdominal obesity. Clin Hemorheol Microcirc 2011;47:75-77.