Comparison of CYFRA 21-1, CEA, CA 19-9 and CA 72-4 levels in gastric cancer

Abstract

Objective: Gastric cancer is the fourth most common malignancy, and the second most common cause of cancer mortality worldwide. The aim of this study was to investigate the role of biomarkers CYFRA 21-1, CA 19-9, CEA, CA72.4 at diagnosis and throughout the follow-up in patients with gastric cancer. Methods: 30 patients with gastric cancer diagnosed and 31 healthy people as a control group were included in this study. According to the TNM staging system, there were 16 patients with stage II and 14 patients with stage III in the group of patients with gastric cancer. CEA, CA 19-9, CA 72-4 and CYFRA 21-1 levels were studied by elektrochemiluminescence immunasay (ECLIA) method in the Cobas e 601 instrument. Results: Statistically the level of CA 72-4, CA 19-9, CEA and CYFRA 21-1 gastric cancer groups was found significant high accaording to healthy control group (p

Keywords

• Gastric cancer
• tumor markers
• CYFRA 21-1

Mide kanserinde CYFRA 21-1, CEA, CA 19-9 ve CA 72-4 düzeylerinin karşılaştırılması

Abstract

Amaç: Mide kanseri dördüncü en sık görülen kanser olup, dünyada kanser ölümlerinin ikinci en sık nedenidir. Bu çalışmada mide kanserinin tanı ve takibinde tümör markırları olan CYFRA 21-1, CA 19-9, CEA ve CA 72-4’ün rollerinin araştırılması amaçlandı.
Yöntemler: Çalışmamıza mide kanseri tanısı almış 30 hasta ve 30 sağlıklı birey alındı. Mide kanserli hasta grubunun TNM evrelendirme sistemine göre 16’sı Evre II, 14’ü Evre III idi. CEA, CA 19-9, CA 72-4 ve CYFRA 21-1 düzeyleri, elektrochemiluminescence immunasay (ECLIA) metod ile Cobas e 601 cihazında çalışıldı.
Bulgular: Mide kanserli hasta grubunun CA 72-4, CA 19- 9, CEA ve CYFRA 21-1 düzeyleri sağlıklı kontrol grubuna göre istatistiksel olarak anlamlı yüksek bulundu (p<0.01). Mide kanserli hastalarda Evre III hasta grubunun CA 19- 9, CEA ve CYFRA 21-1 düzeyleri Evre II hasta grubuna göre istatistiksel olarak anlamlı yüksek bulundu (p<0.01). Tümör markırların kesim değerleri (cut-off), sensitivitesi ve spesifitesi sırayla; CEA için 4.15 ng/mL, %46 ve %96; CA 19-9 için 24.50 U/mL, %17 ve %96; CA 72-4 için 2.46 U/mL, %53 ve %96 ve CYFRA 21-1 için 3.36 ng/mL, %46 ve %100 bulundu.
Sonuç: Çalışmamızda mide kanserli hastaların takibinde CYFRA 21-1, CEA ve CA 72-4’ ün değerli olduğunu saptadık. 

Keywords

• Mide kanseri
• tümör belirteçleri
• CYFRA 21-1

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