Value of a new inflammatory parameter in malignant pleural mesothelioma prognosis

Abstract

Objective: Malignant Pleural Mesothelioma (MPM) generally associated with asbestos exposure is a tumor with poor prognosis. Modified Glasgow Prognostic Score (GPS) which may be a prognostic parameter in patients with MPM is a designed based score including increased C-reactive protein (CRP) levels and decreased albumin .In this study we aimed to investigate the effect of GPS score on the prognosis of MPM and the role of other potential factors. Methods: In this retrospective planned study 140 histological diagnosed MPM patients were included. Results: Mean age of 140 MPM patients were 52.92 years (83 male and 57 female). A total of 91 patients had environmental asbestos exposure and exposure time was the 31 years. Symptoms of the patients started approximately 4.8 months before the application. The most frequently seen symptoms were in 125 patients dyspnea, in 94 patients chest pain and in 22 patients weight loss. GPS score of the patients were as follows; 64 patients two, 14 patients one, 22 patients zero. Of the patients, 112 died and 28 were alive. Mean survival time was 14 months. Patients with GPS score 2 lived for 10 months, GPS score 1 lived for 15 and GPS score 0 lived for 18 months. This difference was statistically significant. Furthermore, the male sex and age older than 65 years were found as poor prognostic parameters on the survival. Conclusion: A simple and inexpensive parameter able to be used to estimate the prognosis of MPM patients could not be developed .GPS score increases in inflammatory conditions. GPS is a simple and inexpensive parameter that can be used for detecting the severity of patients with MPM.

Keywords

• Modified Glasgow Prognostic Score, Malignant Pleural Mesothelioma, Prognosis

Malign Plevral Mezotelyoma prognozunda yeni bir inflamatuar parametrenin değeri

Abstract

Amaç: Malign Plevral Mezotelyoma (MPM) genel olarak asbest teması ile ilişkili ve kötü prognozlu bir tümördür. MPM hastalarında prognostik bir parametre olabilecek olan Modifiye Glasgow Prognoz Skoru (GPS), artmış C-Reaktif Protein (CRP) ve azalmış albümin düzeyleri temel alınarak hazırlanmış bir skordur. Bu çalışmada GPS skorunun MPM prognozu üzerindeki etkilerini incelemek ve diğer potansiyel etkenlerin rollerini araştırmak amaçlanmıştır. Yöntemler: Retrospektif planlanan bu çalışmaya histopatolojik olarak MPM tanısı konan 140 hasta alındı. Bulgular: Toplam 140 MPM hastasının ortalama yaşı 52,92 yıl idi (83 erkek ve 57 kadın) idi. Toplam 91 hastada çevresel asbest teması saptandı ve temas süresi ise 31 yıldı. Hastaların semptomları başvurudan yaklaşık olarak 4,8 ay önce başlamıştı. En sık saptanan semptomlar ise 125 hastada nefes darlığı, 94 hastada göğüs ağrısı ve 22 hastada kilo kaybıydı. GPS skor değeri olarak 64 hasta 2, 22 hasta 1 ve 14 hasta ise sıfır değerini almışlardır. Çalışmaya alınan hastaların 112\'si vefat etmiş ve 28\'i hayattaydı. Tüm hastaların ortalama yaşam süresi 14 ay idi. GPS skoru 2 olan hastalar 10 ay, 1 olanlar 15 ve sıfır olanlar ise yaklaşık 18 ay yaşamışlardır. Bu fark istatistikî olarak önemli bulunmuştur. Ayrıca erkek cinsiyet ve 65 yaş üstü olmada yaşam süresini kötü etkileyen parametreler olarak bulunmuştur. Sonuç: MPM hastalarının prognozunu tahminde kullanılabilecek basit ve ucuz bir parametre geliştirilememiştir. GPS skoru inflamatuar durumlarda artmaktadır. GPS skoru MPM hastalarının ciddiyetini tespitte kullanılabilecek basit ve ucuz bir parametre olarak görülmektedir.

Keywords

• Modifiye Glasgow Prognoz Skoru, Malign Plevral Mezotelyoma, Prognoz

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