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Abstract

Objective: Arsenic is a metal with a widespread industrial usage and causing oxidative stress. Studies shows serum uric acid and gamma gluthamyl transferase (GGT) levels are increasing in oxidative stress. The aim of this study is to evaluate the effect of arsenic exposure on serum uric acid and GGT levels.Methods: 500 patients who refer to Ankara Occupational Disease Hospital between 2010 to 2014 for periodic examination and urinary arsenic, serum uric acid and serum GGT levels assessed are included in this study. 268 patients with urinary arsenic levels over 35μg/L are defined as exposed and below 35μg/L are controls.Results: Data of 500 patients were analysed. 268 of them had high urine arsenic levels and 232 had normal urine arsenic levels. In the high urine arsenic level group the median serum uric acid level was 5.4 (2.60-7.20) and median serum GGT level was 27 in the other group with normal urine arsenic levels the median serum uric acid level was 4.9 and median serum GGT level was 22 . The difference between two groups was statistically significant (p value: 0.002 and <0.001 respectively)Conclusion: Arsenic exposure may be associated with hyperuricemia and high levels of GGT and with prospective studies the causal relationship between arsenic exposure and hyperuricemia and GGT can be revealed

Keywords

• Arsenic exposure, hyperuricemia, gamma gluthamyl transferase

Arsenik maruziyeti olan kişilerde serum gama glutamil transferaz ve ürik asit düzeylerinin değerlendirilmesi

Abstract

Amaç: Arsenik endüstride oldukça yaygın kullanılan ve oksidatif strese neden olduğu bilinen bir metaldir. Serum ürik asit ve gama glutamil transferaz (GGT) düzeylerinin oksidatif stres durumunda arttığını gösteren çalışmalar bulunmaktadır. Bu çalışmanın amacı arsenik maruziyetinin serum ürik asit ve GGT düzeylerine etkisinin araştırılmasıdır.

Yöntemler: 2010-2014 yılları arasında Ankara Meslek Hastalıkları Hastanesine periyodik muayene amaçlı başvuran idrar arsenik, serum ürik asit ve GGT düzeylerine bakılmış 500 kişi çalışmaya dahil edildi. İdrar arsenik düzeyi 35μg/L’nin üzerinde çıkan 268 kişi arsenik maruz grup, 35μg/L’nin altında çıkan 232 kişi ise kontrol grubu olarak kullanıldı.

Bulgular: Arsenik maruz grubun median serum ürik asit değerleri 5,4 (2,60-7,20) median serum GGT değerleri 27 (10-51) idi. Normal idrar arsenik düzeyleri olan diğer grupta ise median serum ürik asit değerleri 4,9 (2,5-7) median serum GGT değerleri 22 (10-52) idi. İki grup arasındaki fark ürik asit ve GGT için anlamlı idi (p değerleri sırasıyla; 0,002, <0,001).

Sonuç: Arsenik maruziyeti hiperürisemi ve yüksek GGT düzeyleri ile ilişkili olabilir. Prospektif çalışmalarla, arsenik maruziyeti ile hiperürisemi, yüksek GGT düzeyleri ve klinik sonuçlar arasındaki nedensel ilişki ortaya çıkarılmalıdır.

Anahtar kelimeler: Arsenik maruziyeti, hiperürisemi, gama glutamil transferaz.

Keywords

• Arsenik maruziyeti, hiperürisemi, gama glutamil transferaz

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