The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy

Sibel Seçkin Pehlivan; Ayşe Ülgey; Adnan Bayram; Cihangir Biçer; Fahri Oğuzkaya; Adem Boyaci

doi:10.5798/dicletip.661256

The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy

Abstract

Objective: The aim of this study was to investigate the effects of a perioperatively administered low dose of ketamine on postoperative acute, chronic pain following thoracotomy. Methods: Forty patients with ASA I–III and aged between 18 and 65 years were included in the study. Patients were randomly divided into two groups. Group I (n=20) was administered a ketamine 0.5 mg.kg-1 bolus followed by a 2 mcg.kg-1.dk-1 infusion for 24 hours before the incision. Group II (n=20) was given normal saline at the same dose and duration. Postoperative analgesia was achieved through patient-controlled morphine administration. Postoperative resting and moving Visual Analogue Scale values, total morphine consumption, preoperative and postoperative values of FVC, FEV1 and FEF25-75 from pulmonary function tests were recorded. Patients were evaluated in terms ofchronicpain in the surgical incision area at 1 and 3 months after the operation. Nausea, vomiting, agitation, delirium, hallucination and sedation scores were recorded. Results: No statistical difference was found between groups in terms of demographic characteristics and operational features. Visual analogue scale values at rest and on movement were significantly lower in Group I. Total morphine consumption was also significantly lower in Group I. There was no difference between the groups in terms of pulmonary function tests. There was no difference between groups in terms of the incidence of chronic pain and development during the first month after the operation, while the incidence of chronic pain in the third month was significantly lower in Group I.No significant difference was observed between groups in terms of sedation scores. The incidence of side effects such as nausea, vomiting, agitation, delirium and hallucinations was similar in both groups. Conclusion: Low-dose ketamine infusion is an efficient method in postoperative acute and chronic pain management after thoracotomy, it reduces analgesic consumption.

Keywords

Ketamine,postoperative analgesia

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sibel Seçkin Pehlivan This is me
0000-0003-3215-5616
Türkiye

Ayşe Ülgey This is me
0000-0002-7634-6214
Türkiye

Adnan Bayram This is me
0000-0002-6700-8301
Türkiye

Cihangir Biçer This is me
0000-0001-8163-6681
Türkiye

Fahri Oğuzkaya This is me
0000-0003-4791-0848
Türkiye

Adem Boyaci This is me
0000-0003-4528-0758
Türkiye

Publication Date

December 15, 2019

Submission Date

May 6, 2019

Acceptance Date

October 10, 2019

Published in Issue

Year 2019 Volume: 46 Number: 4

DOI

https://doi.org/10.5798/dicletip.661256

IZ

https://izlik.org/JA32GA33DF

Cite

RIS / Bibtex

APA

Seçkin Pehlivan, S., Ülgey, A., Bayram, A., Biçer, C., Oğuzkaya, F., & Boyaci, A. (2019). The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy. Dicle Medical Journal, 46(4), 677-684. https://doi.org/10.5798/dicletip.661256

AMA

1.Seçkin Pehlivan S, Ülgey A, Bayram A, Biçer C, Oğuzkaya F, Boyaci A. The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy. Dicle Medical Journal. 2019;46(4):677-684. doi:10.5798/dicletip.661256

Chicago

Seçkin Pehlivan, Sibel, Ayşe Ülgey, Adnan Bayram, Cihangir Biçer, Fahri Oğuzkaya, and Adem Boyaci. 2019. “The Effect of Low Dose Ketamine Infusion on Postoperative Acute and Chronic Pain After Thoracotomy”. Dicle Medical Journal 46 (4): 677-84. https://doi.org/10.5798/dicletip.661256.

EndNote

Seçkin Pehlivan S, Ülgey A, Bayram A, Biçer C, Oğuzkaya F, Boyaci A (December 1, 2019) The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy. Dicle Medical Journal 46 4 677–684.

IEEE

[1]S. Seçkin Pehlivan, A. Ülgey, A. Bayram, C. Biçer, F. Oğuzkaya, and A. Boyaci, “The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy”, Dicle Medical Journal, vol. 46, no. 4, pp. 677–684, Dec. 2019, doi: 10.5798/dicletip.661256.

ISNAD

Seçkin Pehlivan, Sibel - Ülgey, Ayşe - Bayram, Adnan - Biçer, Cihangir - Oğuzkaya, Fahri - Boyaci, Adem. “The Effect of Low Dose Ketamine Infusion on Postoperative Acute and Chronic Pain After Thoracotomy”. Dicle Medical Journal 46/4 (December 1, 2019): 677-684. https://doi.org/10.5798/dicletip.661256.

JAMA

1.Seçkin Pehlivan S, Ülgey A, Bayram A, Biçer C, Oğuzkaya F, Boyaci A. The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy. Dicle Medical Journal. 2019;46:677–684.

MLA

Seçkin Pehlivan, Sibel, et al. “The Effect of Low Dose Ketamine Infusion on Postoperative Acute and Chronic Pain After Thoracotomy”. Dicle Medical Journal, vol. 46, no. 4, Dec. 2019, pp. 677-84, doi:10.5798/dicletip.661256.

Vancouver

1.Sibel Seçkin Pehlivan, Ayşe Ülgey, Adnan Bayram, Cihangir Biçer, Fahri Oğuzkaya, Adem Boyaci. The Effect of Low Dose Ketamine Infusion on Postoperative Acute and chronic Pain after Thoracotomy. Dicle Medical Journal. 2019 Dec. 1;46(4):677-84. doi:10.5798/dicletip.661256

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https://doi.org/10.3389/fmed.2024.1394219