The importance of clinical and pathological features in bladder cancer and its effects on disease course

Sahin Lacin; Nilgun Sogutcu

doi:10.5798/dicletip.661400

The importance of clinical and pathological features in bladder cancer and its effects on disease course

Abstract

Objective: Bladder cancer (BC) is the most common malignancy of the urinary system and the incidence of BC varies regionally. Bladder cancer is more common in men than in women. Tumor stage and grade are the most important prognostic factors of BC. We aimed to describe the patterns of BC presentation and to examine the differences in the distribution of prognostic factors by gender, age, tumor size, and involvement region. Method: The patients diagnosed with BC (non-muscle invasive or muscle-invasive BC) were included. Intravesical treatment, tumor diameter, pathological grade, tumor involved area and tumor stage were recorded as variables. The survival rates of the patients were calculated for diverse clinical and pathological findings. Results:In a total of 124 patients, 23 (18.5%) of patients were female and 101(81.5%) of patients were male, the median age of all patients was 64 (IQR: 21-92). There were 36 % (41) patients in early-stage (stage 0 or stage insitu), 50.9 % (58) patients in stage 1, 7% (8) patients in stage 2, 4.4 %(5) patients in stage 3 and 1.8% (2) patients were in stage 4. There were significantly different OS rates of patients with BC in different stages (p<0.001). Tumor diameter in 36 of patients was < 2.5cm (group 1) and tumor diameter in 28 patients was>2.5cm (group 2). There was a significant difference between the overall survival rates of group 1 and group 2(p=0.02). There were 55 patients with low-grade BC and 38 of patients with high-grade BC, and the difference between their survival rates was statistically significant (p=0.001). Conclusions: Tumor stage, tumor diameter, and grade were demonstrated and confirmed as the crucial prognostic factors of bladder cancer. Additionally, lateral walls of bladder constitute the most commonly involved area, but their roles in the disease course still remain unclear.

Keywords

Bladder cancer,Tumor size

References

1. Ploeg M, Aben KK, KiemeneyLA.The present and future burden of urinary bladder cancer in the world. World J Urol. 2009;27:289-293.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sahin Lacin This is me
0000-0002-1160-0437
Türkiye

Nilgun Sogutcu
0000-0002-2455-2964
Türkiye

Publication Date

December 15, 2019

Submission Date

October 7, 2019

Acceptance Date

November 4, 2019

Published in Issue

Year 2019 Volume: 46 Number: 4

DOI

https://doi.org/10.5798/dicletip.661400

IZ

https://izlik.org/JA63FS56PW

Cite

RIS / Bibtex

APA

Lacin, S., & Sogutcu, N. (2019). The importance of clinical and pathological features in bladder cancer and its effects on disease course. Dicle Medical Journal, 46(4), 821-829. https://doi.org/10.5798/dicletip.661400

AMA

1.Lacin S, Sogutcu N. The importance of clinical and pathological features in bladder cancer and its effects on disease course. Dicle Medical Journal. 2019;46(4):821-829. doi:10.5798/dicletip.661400

Chicago

Lacin, Sahin, and Nilgun Sogutcu. 2019. “The Importance of Clinical and Pathological Features in Bladder Cancer and Its Effects on Disease Course”. Dicle Medical Journal 46 (4): 821-29. https://doi.org/10.5798/dicletip.661400.

EndNote

Lacin S, Sogutcu N (December 1, 2019) The importance of clinical and pathological features in bladder cancer and its effects on disease course. Dicle Medical Journal 46 4 821–829.

IEEE

[1]S. Lacin and N. Sogutcu, “The importance of clinical and pathological features in bladder cancer and its effects on disease course”, Dicle Medical Journal, vol. 46, no. 4, pp. 821–829, Dec. 2019, doi: 10.5798/dicletip.661400.

ISNAD

Lacin, Sahin - Sogutcu, Nilgun. “The Importance of Clinical and Pathological Features in Bladder Cancer and Its Effects on Disease Course”. Dicle Medical Journal 46/4 (December 1, 2019): 821-829. https://doi.org/10.5798/dicletip.661400.

JAMA

1.Lacin S, Sogutcu N. The importance of clinical and pathological features in bladder cancer and its effects on disease course. Dicle Medical Journal. 2019;46:821–829.

MLA

Lacin, Sahin, and Nilgun Sogutcu. “The Importance of Clinical and Pathological Features in Bladder Cancer and Its Effects on Disease Course”. Dicle Medical Journal, vol. 46, no. 4, Dec. 2019, pp. 821-9, doi:10.5798/dicletip.661400.

Vancouver

1.Sahin Lacin, Nilgun Sogutcu. The importance of clinical and pathological features in bladder cancer and its effects on disease course. Dicle Medical Journal. 2019 Dec. 1;46(4):821-9. doi:10.5798/dicletip.661400