The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio

Nizamettin Selçuk Yelgeç; Mehmet Baran Karataş; Can Yücel Karabay; Yiğit Çanga; Ali Nazmi Çalık; Barış Şimşek; Özge Güzelburç; Ayşe Emre

doi:10.5798/dicletip.705532

The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio

Abstract

Objective: Transcatheter aortic valve replacement (TAVR) is a less invasive alternative to open-heart surgery for patients with severe symptomatic aortic stenosis who has a high risk for surgery. Acute kidney injury (AKI) is not a rare complication after TAVR and has been associated with poorer outcomes and survival. This study aims to analyze the relation between serum Neutrophil-lymphocyte ratio (NLR) and AKI in Post-TAVR patients. Methods: 148 patients who have been performed TAVR at our institution between 2010 and 2018, analyzed retrospectively. We divided the patients into two groups. Group 1 (n=116): The patients who did not develop AKI after TAVR procedure (control group) and Group 2 (n=32): The patients who developed AKI after TAVR. The independent relation between possible independent predictors of AKI in post-TAVI patients was analyzed by regression analysis. Results: 32 patients (22%) suffered from AKI after TAVR during hospitalization. NLR was significantly associated with the development of AKI (3.22 ±0.62 vs. 2.42 ± 0.45, p<0.01). In multivariate regression analysis, NLR (OR: 1.79, p=0,01), diabetes mellitus (OR: 1.41, p=0,01), and preprocedural creatinine levels (OR: 1.86, p=0,01) were found to be independently correlated with the development of AKI after TAVR. Conclusion: This study suggests that High NLR was independently associated with AKI in post-TAVR patients. High values of NLR may indicate a poor prognosis.

Keywords

Neutrophil to lymphocyte ratio,Transcatheter aortic valve implantation

References

1. Lindman BR, Clavel M-A, Mathieu P, et al. Calcific aortic stenosis. Nat Rev Dis Prim. 2016; 2: 16006.
2. Eveborn GW, Schirmer H, Heggelund G, et al. The evolving epidemiology of valvular aortic stenosis. theTromsø Study. Heart. 2013 Mar 15; 99: 396–400.
3. Nishimura RA, Otto CM, Bonow RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am CollCardiol. 2014 Jun 10; 63: e57-185.
4. Bagur R, Webb JG, Nietlispach F, et al. Acute kidney injury following transcatheter aortic valve implantation: predictive factors, prognostic value, and comparison with surgical aortic valve replacement. Eur Heart J. 2010 Apr 1; 31: 865–74.
5. Najjar M, Salna M, George I. Acute kidney injury after aortic valve replacement: Incidence, risk factors and outcomes. Expert Review of Cardiovascular Therapy. 2015.
6. Papa A, Emdin M, Passino C, et al. Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. ClinChimActa. 2008 Sep; 395: 27–31.
7. Park B-J, Shim J-Y, Lee H-R, et al. Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score. ClinChimActa. 2011 May 12; 412: 925–9.
8. Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome. Arq Bras Cardiol. 2008 Jan; 90: 31–6.

9. Duffy BK, Gurm HS, Rajagopal V, et al. Usefulness of an Elevated Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality After Percutaneous Coronary Intervention. Am J Cardiol. 2006 Apr 1; 97: 993–6.
10. Gibson PH, Cuthbertson BH, Croal BL, et al. Usefulness of Neutrophil/Lymphocyte Ratio As Predictor of New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting. Am J Cardiol. 2010 Jan 15; 105: 186–91.
11. Rudiger A, Burckhardt OA, Harpes P, et al. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med. 2006 Jul; 24: 451–4.
12. Gibson PH, Croal BL, Cuthbertson BH, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J. 2007 Nov; 154: 995–1002.
13. Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev CardiovascTher. 2013 Jan 10; 11: 55–9.
14. Kappetein AP, Head SJ, Généreux P, et al. Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document†. Eur Heart J. 2012 Oct; 33: 2403–18.
15. Roques F, Michel P, Goldstone AR, et al. The logistic EuroSCORE. Eur Heart J. 2003 May 1; 24: 882–3.
16. Park JJ, Jang HJ, Oh IY, et al. Prognostic value of neutrophil to lymphocyte ratio in patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2013;
17. Bhat T, Teli S, Rijal J, et al. Neutrophil to lymphocyte ratio and cardiovascular diseases: A review. Expert Review of Cardiovascular Therapy. 2013.
18. Onuk T, Güngör B, Karataş B, et al. Increased neutrophil to lymphocyte ratio is associated with in-hospital mortality in patients with aortic dissection. Clin Lab. 2015; 61.
19. Yin Y, Wang J, Wang X, et al. Prognostic value of the neutrophil to lymphocyte ratio in lung cancer: A meta-analysis. Clinics. 2015;
20. Turkmen K, Guney I, Yerlikaya FH, et al. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail. 2012; 34: 155–9.
21. Erdem E. Neutrophil lymphocyte ratio in aute renal failure. Indian J Nephrol. 2015; 25: 126–7.
22. Mozos I, Malainer C, Horbańczuk J, et al. Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases. Front Immunol. 2017 Aug 31; 8: 1058.
23. Li J, Chen Q, Luo X, et al. Neutrophil-to-Lymphocyte Ratio Positively Correlates to Age in Healthy Population. J Clin Lab Anal. 2015 Nov; 29: 437–43.
24. Nam S-H, Kang S-G, Song S-W. The Neutrophil-Lymphocyte Ratio Is Associated with Coronary Artery Calcification in Asymptomatic Korean Males: A Cross-Sectional Study. Biomed Res Int. 2017 Feb 9; 2017: 1–8.
25. Candela P, Evola S, Lunetta M, et al. The spectrum of risk factors for contrast induced nephropathy in patients undergoing coronary angiography or intervention. J Indian CollCardiol. 2014 Sep 1; 4: 157–61.
26. Gürsoy OM, Karakoyun S, Kalçık M, et al. Usefulness of Novel Hematologic Inflammatory Parameters to Predict Prosthetic Mitral Valve Thrombosis. Am J Cardiol. 2014 Mar; 113: 860–4.
27. Ram P, Mezue K, Pressman G, et al. Acute kidney injury post-transcatheter aortic valve replacement. ClinCardiol. 2017 Dec 1; 40: 1357–62.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Nizamettin Selçuk Yelgeç ^* This is me
Türkiye

Mehmet Baran Karataş This is me
Türkiye

Can Yücel Karabay This is me
Türkiye

Yiğit Çanga This is me
Türkiye

Ali Nazmi Çalık This is me
Türkiye

Barış Şimşek This is me
Türkiye

Özge Güzelburç This is me
Türkiye

Ayşe Emre This is me
Türkiye

Publication Date

March 17, 2020

Submission Date

October 2, 2019

Acceptance Date

February 11, 2020

Published in Issue

Year 2020 Volume: 47 Number: 1

DOI

https://doi.org/10.5798/dicletip.705532

IZ

https://izlik.org/JA46LC38LH

Cite

RIS / Bibtex

APA

Yelgeç, N. S., Karataş, M. B., Karabay, C. Y., Çanga, Y., Çalık, A. N., Şimşek, B., Güzelburç, Ö., & Emre, A. (2020). The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio. Dicle Medical Journal, 47(1), 1-9. https://doi.org/10.5798/dicletip.705532

AMA

1.Yelgeç NS, Karataş MB, Karabay CY, et al. The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio. Dicle Medical Journal. 2020;47(1):1-9. doi:10.5798/dicletip.705532

Chicago

Yelgeç, Nizamettin Selçuk, Mehmet Baran Karataş, Can Yücel Karabay, et al. 2020. “The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio”. Dicle Medical Journal 47 (1): 1-9. https://doi.org/10.5798/dicletip.705532.

EndNote

Yelgeç NS, Karataş MB, Karabay CY, Çanga Y, Çalık AN, Şimşek B, Güzelburç Ö, Emre A (March 1, 2020) The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio. Dicle Medical Journal 47 1 1–9.

IEEE

[1]N. S. Yelgeç et al., “The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio”, Dicle Medical Journal, vol. 47, no. 1, pp. 1–9, Mar. 2020, doi: 10.5798/dicletip.705532.

ISNAD

Yelgeç, Nizamettin Selçuk - Karataş, Mehmet Baran - Karabay, Can Yücel - Çanga, Yiğit - Çalık, Ali Nazmi - Şimşek, Barış - Güzelburç, Özge - Emre, Ayşe. “The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio”. Dicle Medical Journal 47/1 (March 1, 2020): 1-9. https://doi.org/10.5798/dicletip.705532.

JAMA

1.Yelgeç NS, Karataş MB, Karabay CY, Çanga Y, Çalık AN, Şimşek B, Güzelburç Ö, Emre A. The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio. Dicle Medical Journal. 2020;47:1–9.

MLA

Yelgeç, Nizamettin Selçuk, et al. “The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio”. Dicle Medical Journal, vol. 47, no. 1, Mar. 2020, pp. 1-9, doi:10.5798/dicletip.705532.

Vancouver

1.Nizamettin Selçuk Yelgeç, Mehmet Baran Karataş, Can Yücel Karabay, Yiğit Çanga, Ali Nazmi Çalık, Barış Şimşek, Özge Güzelburç, Ayşe Emre. The Relationship Between Acute Renal Failure After Transcatheter Aortic Valve Replacement And Preprocedural Neutrophil To Lymphocyte Ratio. Dicle Medical Journal. 2020 Mar. 1;47(1):1-9. doi:10.5798/dicletip.705532

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