Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Reyhan Gündüz; Mete Gurol Ugur; Neslihan Bayramoğlu Tepe; Hüseyin Çağlayan Özcan; Özcan Balat; Sevgi Sari Demir; Seyithan Taysi

doi:10.5798/dicletip.706022

Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study

Abstract

Objective: This study was aimed to evaluate 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA) levels in patients with first trimester miscarriage. Methods: This prospective cohort study included 35 women, who were diagnosed with miscarriage (patient group) and 35 healthy pregnant women below 14 weeks of gestation (control group), who did not report any complaints. 8-OHdG levels were measured with a competitive ELISA (Enzyme-Linked ImmunoSorbent Assay) high sensitivity kit and MDA levels were also measured in both groups. Results: There wasn’t difference in terms of complete blood count, thyroid-stimulating hormone (TSH), homocysteine values, parity, age, body mass index (BMI) and gestational age between the groups. Serum 8-OHdG and MDA levels were significantly higher in the patient group (p=0.001). A moderate positive significant correlation between the gestational week and MDA values and a weak but significant positive correlation between 8-OHdG values and gestational week were detected in the patient group. Conclusion: 8-OHdG and MDA could play a role in the etiopathogenesis of first-trimester miscarriage. However, this role must be further delineated in large-scaled studies for early diagnosis and management of this condition.

Keywords

Oxidative Stress,malondialdehyde,8-hydroxy-2-deoxyguanosine,miscarriage

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Reyhan Gündüz ^* This is me
Türkiye

Mete Gurol Ugur This is me
Türkiye

Neslihan Bayramoğlu Tepe This is me
Türkiye

Hüseyin Çağlayan Özcan This is me
Türkiye

Özcan Balat This is me
Türkiye

Sevgi Sari Demir This is me
Türkiye

Seyithan Taysi This is me
Andorra

Publication Date

March 17, 2020

Submission Date

October 24, 2019

Acceptance Date

January 22, 2020

Published in Issue

Year 2020 Volume: 47 Number: 1

DOI

https://doi.org/10.5798/dicletip.706022

IZ

https://izlik.org/JA46JU84XK

Cite

RIS / Bibtex

APA

Gündüz, R., Ugur, M. G., Tepe, N. B., Özcan, H. Ç., Balat, Ö., Demir, S. S., & Taysi, S. (2020). Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal, 47(1), 74-81. https://doi.org/10.5798/dicletip.706022

AMA

1.Gündüz R, Ugur MG, Tepe NB, et al. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal. 2020;47(1):74-81. doi:10.5798/dicletip.706022

Chicago

Gündüz, Reyhan, Mete Gurol Ugur, Neslihan Bayramoğlu Tepe, et al. 2020. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal 47 (1): 74-81. https://doi.org/10.5798/dicletip.706022.

EndNote

Gündüz R, Ugur MG, Tepe NB, Özcan HÇ, Balat Ö, Demir SS, Taysi S (March 1, 2020) Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal 47 1 74–81.

IEEE

[1]R. Gündüz et al., “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”, Dicle Medical Journal, vol. 47, no. 1, pp. 74–81, Mar. 2020, doi: 10.5798/dicletip.706022.

ISNAD

Gündüz, Reyhan - Ugur, Mete Gurol - Tepe, Neslihan Bayramoğlu - Özcan, Hüseyin Çağlayan - Balat, Özcan - Demir, Sevgi Sari - Taysi, Seyithan. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal 47/1 (March 1, 2020): 74-81. https://doi.org/10.5798/dicletip.706022.

JAMA

1.Gündüz R, Ugur MG, Tepe NB, Özcan HÇ, Balat Ö, Demir SS, Taysi S. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal. 2020;47:74–81.

MLA

Gündüz, Reyhan, et al. “Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study”. Dicle Medical Journal, vol. 47, no. 1, Mar. 2020, pp. 74-81, doi:10.5798/dicletip.706022.

Vancouver

1.Reyhan Gündüz, Mete Gurol Ugur, Neslihan Bayramoğlu Tepe, Hüseyin Çağlayan Özcan, Özcan Balat, Sevgi Sari Demir, Seyithan Taysi. Evaluation Of 8-Hydroxy-2-Deoxyguanosine And Malondialdehyde Levels In First-Trimester Miscarriage: A Prospective Cohort Study. Dicle Medical Journal. 2020 Mar. 1;47(1):74-81. doi:10.5798/dicletip.706022

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