The Relationship Between MicroRNAs And Congenital Kidney Anomalies

Kenan Yılmaz; Zubeyde Gunduz; Mehmet Serdar Kutuk; Ruhan Dusunsel; İsmail Dursun; Sibel Yel

doi:10.5798/dicletip.706048

The Relationship Between MicroRNAs And Congenital Kidney Anomalies

Abstract

Objective: The purpose of this study was to identify diagnostic microRNAs (miRNAs) associated with congenital kidney anomalies. Methods: Twenty-five healthy pregnant women who were found to have fetal kidney anomaly in the second trimester of their pregnancy at Department of Perinatology, were included in the study. Serum samples were taken from the pregnant women at the moment of diagnosis in the antenatal 20th gestational week, whereas serum samples were taken from the cord blood of babies during birth. There were 11 multicystic dysplastic kidney patients, 6 autosomal recessive polycystic kidney patients, and 8 unilateral hypoplastic kidney patients. Expression of specific miRNAs was monitored using specific primer assays in Real-Time PCR. The expression of the following miRNAs was quantified: miR-17, miR-192, miR-194, miR-204, miR-215, and miR-216. Results: mir-17 expression was significantly lower in children with congenital kidney anomalies than in the control group. ROC curve analysis showed that the area under the curve was 0.700 for miR-17 in the prediction of congenital kidney anomalies. Conclusions: In children with congenital kidney anomalies, miR-17 expression was significantly different than in the control group. Thus, this miRNA may be used in the antenatal early detection of these congenital kidney anomalies.

Keywords

microRNAs; kidney development; biomarker; prenatal diagnosis; children

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Kenan Yılmaz ^* This is me
Türkiye

Zubeyde Gunduz This is me
Türkiye

Mehmet Serdar Kutuk This is me
Türkiye

Ruhan Dusunsel This is me
Türkiye

İsmail Dursun This is me
Türkiye

Sibel Yel This is me
Türkiye

Publication Date

March 17, 2020

Submission Date

December 20, 2019

Acceptance Date

February 11, 2020

Published in Issue

Year 2020 Volume: 47 Number: 1

DOI

https://doi.org/10.5798/dicletip.706048

IZ

https://izlik.org/JA75PK33GS

Cite

RIS / Bibtex

APA

Yılmaz, K., Gunduz, Z., Kutuk, M. S., Dusunsel, R., Dursun, İ., & Yel, S. (2020). The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal, 47(1), 89-96. https://doi.org/10.5798/dicletip.706048

AMA

1.Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal. 2020;47(1):89-96. doi:10.5798/dicletip.706048

Chicago

Yılmaz, Kenan, Zubeyde Gunduz, Mehmet Serdar Kutuk, Ruhan Dusunsel, İsmail Dursun, and Sibel Yel. 2020. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal 47 (1): 89-96. https://doi.org/10.5798/dicletip.706048.

EndNote

Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S (March 1, 2020) The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal 47 1 89–96.

IEEE

[1]K. Yılmaz, Z. Gunduz, M. S. Kutuk, R. Dusunsel, İ. Dursun, and S. Yel, “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”, Dicle Medical Journal, vol. 47, no. 1, pp. 89–96, Mar. 2020, doi: 10.5798/dicletip.706048.

ISNAD

Yılmaz, Kenan - Gunduz, Zubeyde - Kutuk, Mehmet Serdar - Dusunsel, Ruhan - Dursun, İsmail - Yel, Sibel. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal 47/1 (March 1, 2020): 89-96. https://doi.org/10.5798/dicletip.706048.

JAMA

1.Yılmaz K, Gunduz Z, Kutuk MS, Dusunsel R, Dursun İ, Yel S. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal. 2020;47:89–96.

MLA

Yılmaz, Kenan, et al. “The Relationship Between MicroRNAs And Congenital Kidney Anomalies”. Dicle Medical Journal, vol. 47, no. 1, Mar. 2020, pp. 89-96, doi:10.5798/dicletip.706048.

Vancouver

1.Kenan Yılmaz, Zubeyde Gunduz, Mehmet Serdar Kutuk, Ruhan Dusunsel, İsmail Dursun, Sibel Yel. The Relationship Between MicroRNAs And Congenital Kidney Anomalies. Dicle Medical Journal. 2020 Mar. 1;47(1):89-96. doi:10.5798/dicletip.706048