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The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children

Year 2020, , 268 - 277, 17.06.2020

Fatma Demirbaş Ayşe Engin Arısoy Hakan Demir

https://doi.org/10.5798/dicletip.755695
Cited By: 1

Abstract

Objective: Very low birth weight (VLBW) infants are at increased risk of osteopenia of prematurity due to interruption of intrauterine bone mineralization. In this study aimed to evaluate the bone mineral density (BMD) by evaluating DXA in children aged 5-7 years with VLBW and preterm birth.
Methods: This study was conducted prospectively between February 2011 and September 2012. Seventy-five children aged 5-7 years, who were born under 1.500 grams were included.
Results: Bone density measurements of the study group (42 female 56%) were found to be low compared to the DXA reference values (p < 0.001). According to the L1-L4 Z score, bone density was found to be low in 21.33% (n: 16) of the cases. Total femur Z score (p = 0.018), femur neck BMD (p = 0.001), total femur BMD (p = 0.012) values were significantly lower in females than males. Whole body BMD values (p = 0.021) were significantly lower in patients receiving postnatal systemic steroids than in the non-receiving group. Femur neck BMD values of the patients who received only breast milk in the first six months were found to be statistically significantly higher than those who received only formula in the first six months (p = 0.034).A significant correlation was found between the current height, weight, BMI increase and BMD measurement.
Conclusion: In this study, it was shown that bone diseases in VLBW and preterm infants affect bone mineralization in long term. We determined the effects of drugs and nutrition used in treatments and current anthropometric measurements on bone health of preterm and VLBW.

Keywords

bone mineral density osteoporosis prematurity

References

  • 1. Katar S., Devecioğlu C. Outcome of Very Low Birth Weight Infants in Neonatal Care Unit of Dicle University Faculty of Medicine. Dicle Med J 2006; 33: 248-51.
  • 2. Ukarapong S, Venkatarayappa SKB, Navarrete C, Berkovitz G. Risk factors of metabolic bone of prematurity. Early Hum Dev. 2017; 112: 29–34.
  • 3. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA. Bone densitometry in Canadian children 8 – 17 years of age. Calcif Tissue Int. 1996; 59:344-51.
  • 4. Körnmann MN, Christmann V, Charlotte J, et al. Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period. Nutrients. 2017; 9: 1318.
  • 5. Cooper C, Cawley M, Bhalla A, et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995; 10: 940–7.
  • 6. Kurl K, Heinonen K, Länsimies E, Launiala K. Determinants of bone mineral density in prematurely born children aged 6–7 years Acta Paediatr. 1998; 87:650-3.
  • 7. Armstrong C, Chan GM, Moyer-Mileur L, Archuleta M. Seven year follow-up of premature infants’ bone mineralization (abstract). Pediatr Res. 1997; 41: 190.
  • 8. Rubinacci A, Sirtori P. Moro G, Galli L, Minoli I, Tessari L. Is there an impact of birth weight and early life on bone mineral contect in premature born infants and children? Acta Paediatr. 1993; 82: 711-3.
  • 9. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA. Bone densitometry in Canadian children 8 – 17 years of age. Calcif Tissue Int. 1996; 59:344–51.
  • 10. Faienza MF, D'Amato E, Natale MP, et al. Metabolic Bone Disease of Prematurity: Diagnosis and Management. Front Pediatr. 2019; 7: 143.
  • 11. So KW, Ng PC: Treatment and prevention of neonatal osteopenia. Current Paediatrics.2005; 15: 106-13.
  • 12. Sharp M. Bone disease of prematurity. Early Hum Dev. 2007; 83: 653-58.
  • 13. Figueras-Aloy J, Álvarez-Domínguez E, Pérez-Fernández JM, et al. Metabolic bone disease and bone mineral density in very preterm infants. J Pediatr. 2014; 164: 499–504.
  • 14. Seeman E, Wahner HW, Offord KP, et al. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest. 1982; 69: 1302-9.
  • 15. Bowden LS, Jones CA, Ryan SW. Bone mineralization in ex- preterm infants aged 8 years. Eur J Pediatr. 1999; 158: 658-61.
  • 16. Eelloo JA, Roberts SA, Emmerson AJ, et al. Bone status of children aged 5-8 years, treated with dexamethasone for chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008; 93: 222-24.
  • 17. Breukhoven PE, Leunissen WJ, Kort WK S, et al. Preterm birth does not affect bone mineral density in young adults. Eur J Endocrinol. 2011; 164: 133-38.
  • 18. Erlandson MC, Sherar LB, Baxter-Jones AD, et al. Premature Birth and Adolescent Bone MineralContent. Am J Perinatol. 2011; 28:157-63.
  • 19. Weiler HA, Yuen CK, Seshia MM. Growth and bone mineralization of young adults weighing less than 1500 g at birth. Early Hum Dev. 2002; 67: 101–12.
  • 20. Xie LF, Alos N, Cloutier A, et al. The long-term impact of very preterm birth on adult bone mineral density. Bone Rep. 2018; 10: 100189.
  • 21. Hovi P, Andersson S, Ja¨rvenpa¨a AL, et al. Decreased Bone Mineral Density in Adults Born with Very Low Birth Weight: A Cohort Study. PLoS Med. 2009; 6: 1000135.
  • 22. Fewtrell MS, Prentice A, Jones SC, et al. Bone mineralization and turnover in premature infants at 8–12 years of age: the effect of early diet. J Bone Miner Res 1999; 14: 810–20.
  • 23. Christmann V, van der Putten ME, Rodwell L, et al. Effect of early nutritional intake on long-term growth and bone mineralization of former very low birth weight infants. Bone. 2018; 108: 89-97.
  • 24. Kroger H, Kotaniemi A, VainoP, Alhava E. Bone dansitometry the spine and femur in children by dual-energy X-ray absorptiometry. Bone Miner. 1992; 17: 75-85.
  • 25. Awad HA, Farid TM, Khafagy SM, Nofal RI. Bone Mineral Content Measured by DEXA Scan in Preterm Neonates Receiving Total Parentral Nutrition with and without Phosphorus Supplementation. Pak J Biol Sci. 2010; 13: 891-95.
  • 26. Neyzi O, Bundak R, Gökçay G, et al. Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol. 2015; 7: 280-93.

Year 2020, , 268 - 277, 17.06.2020

Fatma Demirbaş Ayşe Engin Arısoy Hakan Demir

https://doi.org/10.5798/dicletip.755695
Cited By: 1

Abstract

References

  • 1. Katar S., Devecioğlu C. Outcome of Very Low Birth Weight Infants in Neonatal Care Unit of Dicle University Faculty of Medicine. Dicle Med J 2006; 33: 248-51.
  • 2. Ukarapong S, Venkatarayappa SKB, Navarrete C, Berkovitz G. Risk factors of metabolic bone of prematurity. Early Hum Dev. 2017; 112: 29–34.
  • 3. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA. Bone densitometry in Canadian children 8 – 17 years of age. Calcif Tissue Int. 1996; 59:344-51.
  • 4. Körnmann MN, Christmann V, Charlotte J, et al. Growth and Bone Mineralization of Very Preterm Infants at Term Corrected Age in Relation to Different Nutritional Intakes in the Early Postnatal Period. Nutrients. 2017; 9: 1318.
  • 5. Cooper C, Cawley M, Bhalla A, et al. Childhood growth, physical activity, and peak bone mass in women. J Bone Miner Res. 1995; 10: 940–7.
  • 6. Kurl K, Heinonen K, Länsimies E, Launiala K. Determinants of bone mineral density in prematurely born children aged 6–7 years Acta Paediatr. 1998; 87:650-3.
  • 7. Armstrong C, Chan GM, Moyer-Mileur L, Archuleta M. Seven year follow-up of premature infants’ bone mineralization (abstract). Pediatr Res. 1997; 41: 190.
  • 8. Rubinacci A, Sirtori P. Moro G, Galli L, Minoli I, Tessari L. Is there an impact of birth weight and early life on bone mineral contect in premature born infants and children? Acta Paediatr. 1993; 82: 711-3.
  • 9. Faulkner RA, Bailey DA, Drinkwater DT, McKay HA, Arnold C, Wilkinson AA. Bone densitometry in Canadian children 8 – 17 years of age. Calcif Tissue Int. 1996; 59:344–51.
  • 10. Faienza MF, D'Amato E, Natale MP, et al. Metabolic Bone Disease of Prematurity: Diagnosis and Management. Front Pediatr. 2019; 7: 143.
  • 11. So KW, Ng PC: Treatment and prevention of neonatal osteopenia. Current Paediatrics.2005; 15: 106-13.
  • 12. Sharp M. Bone disease of prematurity. Early Hum Dev. 2007; 83: 653-58.
  • 13. Figueras-Aloy J, Álvarez-Domínguez E, Pérez-Fernández JM, et al. Metabolic bone disease and bone mineral density in very preterm infants. J Pediatr. 2014; 164: 499–504.
  • 14. Seeman E, Wahner HW, Offord KP, et al. Differential effects of endocrine dysfunction on the axial and the appendicular skeleton. J Clin Invest. 1982; 69: 1302-9.
  • 15. Bowden LS, Jones CA, Ryan SW. Bone mineralization in ex- preterm infants aged 8 years. Eur J Pediatr. 1999; 158: 658-61.
  • 16. Eelloo JA, Roberts SA, Emmerson AJ, et al. Bone status of children aged 5-8 years, treated with dexamethasone for chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 2008; 93: 222-24.
  • 17. Breukhoven PE, Leunissen WJ, Kort WK S, et al. Preterm birth does not affect bone mineral density in young adults. Eur J Endocrinol. 2011; 164: 133-38.
  • 18. Erlandson MC, Sherar LB, Baxter-Jones AD, et al. Premature Birth and Adolescent Bone MineralContent. Am J Perinatol. 2011; 28:157-63.
  • 19. Weiler HA, Yuen CK, Seshia MM. Growth and bone mineralization of young adults weighing less than 1500 g at birth. Early Hum Dev. 2002; 67: 101–12.
  • 20. Xie LF, Alos N, Cloutier A, et al. The long-term impact of very preterm birth on adult bone mineral density. Bone Rep. 2018; 10: 100189.
  • 21. Hovi P, Andersson S, Ja¨rvenpa¨a AL, et al. Decreased Bone Mineral Density in Adults Born with Very Low Birth Weight: A Cohort Study. PLoS Med. 2009; 6: 1000135.
  • 22. Fewtrell MS, Prentice A, Jones SC, et al. Bone mineralization and turnover in premature infants at 8–12 years of age: the effect of early diet. J Bone Miner Res 1999; 14: 810–20.
  • 23. Christmann V, van der Putten ME, Rodwell L, et al. Effect of early nutritional intake on long-term growth and bone mineralization of former very low birth weight infants. Bone. 2018; 108: 89-97.
  • 24. Kroger H, Kotaniemi A, VainoP, Alhava E. Bone dansitometry the spine and femur in children by dual-energy X-ray absorptiometry. Bone Miner. 1992; 17: 75-85.
  • 25. Awad HA, Farid TM, Khafagy SM, Nofal RI. Bone Mineral Content Measured by DEXA Scan in Preterm Neonates Receiving Total Parentral Nutrition with and without Phosphorus Supplementation. Pak J Biol Sci. 2010; 13: 891-95.
  • 26. Neyzi O, Bundak R, Gökçay G, et al. Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol. 2015; 7: 280-93.
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Fatma Demirbaş This is me

Ayşe Engin Arısoy This is me

Hakan Demir This is me

Publication Date June 17, 2020
Submission Date March 25, 2020
Published in Issue Year 2020

Cite

APA Demirbaş, F., Engin Arısoy, A., & Demir, H. (2020). The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children. Dicle Tıp Dergisi, 47(2), 268-277. https://doi.org/10.5798/dicletip.755695
AMA Demirbaş F, Engin Arısoy A, Demir H. The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children. diclemedj. June 2020;47(2):268-277. doi:10.5798/dicletip.755695
Chicago Demirbaş, Fatma, Ayşe Engin Arısoy, and Hakan Demir. “The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children”. Dicle Tıp Dergisi 47, no. 2 (June 2020): 268-77. https://doi.org/10.5798/dicletip.755695.
EndNote Demirbaş F, Engin Arısoy A, Demir H (June 1, 2020) The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children. Dicle Tıp Dergisi 47 2 268–277.
IEEE F. Demirbaş, A. Engin Arısoy, and H. Demir, “The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children”, diclemedj, vol. 47, no. 2, pp. 268–277, 2020, doi: 10.5798/dicletip.755695.
ISNAD Demirbaş, Fatma et al. “The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children”. Dicle Tıp Dergisi 47/2 (June 2020), 268-277. https://doi.org/10.5798/dicletip.755695.
JAMA Demirbaş F, Engin Arısoy A, Demir H. The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children. diclemedj. 2020;47:268–277.
MLA Demirbaş, Fatma et al. “The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children”. Dicle Tıp Dergisi, vol. 47, no. 2, 2020, pp. 268-77, doi:10.5798/dicletip.755695.
Vancouver Demirbaş F, Engin Arısoy A, Demir H. The Long-Term Effect of Very Low Birth Weight and Prematurity On Bone Mineral Density In 5-7 Years Old Children. diclemedj. 2020;47(2):268-77.

Cited By

Osteopenia of prematurity and associated nutritional factors: case–control study
BMC Pediatrics
https://doi.org/10.1186/s12887-022-03581-y