The Monocyte To High-Density Lipoprotein Cholesterol Ratio Predicts The Mortality in Patients With Reduced Ejection Fraction Heart Failure

Abstract

The Monocyte To High-Density Lipoprotein Cholesterol Ratio Predicts The Mortality in Patients With Reduced Ejection Fraction Heart Failure

Abstract

Objective: We purposed to evaluate the association between Monocyte To High-Density Lipoprotein Cholesterol Ratio (MHR) and mortality during a year follow-up in patients with reduced efection fraction heart failure (HFrEF). Method: We included total of 552 patients with HFrEF into the study. The main outcome was mortality at 1-year follow-up. Sociodemographic characteristics, hemogram and biochemical parameters, ejection fractions of patients were recorded. MHR was was computed by splitting monocyte into high-density lipoprotein cholesterol (HDL-C). Results: The HFrEF population were seperated into different groups as non-survivors (n=45) and survivors (n=507). When the groups are compared the non-survivors group was older (p=0.04) and chronic renal failure incidence was higher in non-survivors (p=0.001). The MHR was notably higher in the non-survivors group (p=0.000). We have shown that MHR had a positive correlation with mortality (r=0.146 p=0.001). Also higher MHR was found as a strong paramer to predict of mortality (Odds ratio: 2.471, 95% confidence interval: 1.729–4.092, P=0.005). The cut-off values of 6,39 might be applied for predicting the mortality with 88% sensitivity and 97% specificity [Area under curve:0.831 (95% Confidence Interval: 0.799-0.869) p=0.001]. Conclusion: MHR can be used as an easy and usefull tool to predict mortality in HFrEF patients.

Keywords

• heart failure
• mortality
• monocyte to high-density lipoprotein cholesterol ratio

References

1. 1.Yancy CW, Jessup M, Bozkurt B, et al. 2013ACCF/AHA guideline for the management of heartfailure: a report of the American College of Cardiology Foundation/American Heart Association Task Forceon Practice Guidelines. J. Am. Coll. Cardiol. 2013; 62:e147-e239.