Relationship Between Paraoxonase-1 Activity and Pulse Pressure Index in Patients with a Acute Ischemic Stroke

Abstract

Relationship Between Paraoxonase-1 Activity and Pulse Pressure Index in Patients with a Acute Ischemic Stroke

Abstract

Objectives: Stroke is a multifactorial disease. Oxidative stress and blood pressure were found to be closely related with cardiovascular and cerebrovascular diseases. Paraoxonase-1 (PON1) has been considered as an anti-atherosclerosis factor. Increased pulse pressure (PP) may lead to an increased risk of cardiovascular and cerebrovascular morbidity and mortality. Nevertheless, there are limitations for PP as an evaluation index. In order to overcome the defects of PP, there is a novel parameter, “pulse pressure/systolic pressure” called “pulse pressure index (PPI)” for evaluation of cardiovascular outcomes. We investigated the association between Paraoxonase-1 (PON1) activities and pulse pressure index (PPI) in acute ischemic stroke patients. Methods: We evaluated and compared the PON-1 activity and PPI in 46 ischemic stroke patients and 32 control patients. PON1 activitity was measured with UV spectrophotometric method by using “Rel Assay Diagnostic” kits. Pulse pressure was calculated by subtraction of diastolic blood pressure from systolic blood pressure. PPI was calculated “pulse pressure / systolic pressure”. Results: Hypertension, age, diabetes mellitus, dyslipidemia signficantly higher in ischemic stroke patients than control group (p<0.05). PPI was significantly higher in ischemic stroke patients than control group (0.471 ± 0.072 and 0.423 ± 0.048, p<0.05). PON-1 activity was significantly lower in ischemic stroke patients than in control group (417.76 ± 79.72 and 432.34 ± 92.05 p<0.05). We found that a weak negative correlation between the PPI and LVEF, PON1 (p<0.05). Also, PON1 is independent predictor of PPI. Conclusion: This study demostrated that PON1 activity is lower and PPI is higher in acute ischemic stroke patients than control subjects. Our results suggested that, PON-1 activity is an independent predictor of PPI in acute ischemic stroke patients. PON-1 weakly correlates with pulse pressure index.

Keywords

• Paraoxonase
• pulse pressure
• stroke

References

1. 1.Kim NS, Kang K, Cha MH, et al. Decreasedparaoxonase-1 activity is a risk factor for ischemicstroke in Koreans. Biochem Biophys Res Commun.2007; 364: 157-62.