Anaesthetic management of a patient with hereditary angioedema

Year 2015, Volume: 42 Issue: 4, - , 08.01.2016

Nergis Ataol Murat Öksüz Feride Korkmaz Alaattin Öztürk

Abstract

Hereditary angioedema is a rare autosomal dominant disorder caused by reduced activity of the C1 esterase inhibitor. Patients with hereditary angioedema are clinically characterized by recurrent episodes of swelling of the extremities, face, trunk, airways and abdominal organs. Attacks may occur either spontaneously or following trauma, stress, surgery, infections and hormonal fluctuations. The most common cause of death is asphyxia related to laryngeal edema. Giving C1 esterase inhibitor is the most effective method of treatment. Also fresh frozen plasma, androgen steroids, quinine pathway inhibitors, antifibrinolytics and bradykinin receptor antagonists can be used as treatment. In this paper, the anesthetic management of a patient with hereditary angioedema undergoing inguinal hernia repair surgery is reported.

Key words: Hereditary angioedema; C1 esterase inhibitor; Inguinal hernia

Keywords

Herediter anjioödem, C1 esteraz inhibitörü, İnguinal herni

References

• Farkas H, Harmat G, Fust G, et al. Clinical management of
• hereditary angio-oedema in children. Pediatr Allergy Immunol
• ;13:153-161.
• Cicardi M, Agostoni A. Hereditary angioedema. N Engl J
• Med 1996;334:1666-1667.
• Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema:
• new findings concerning symptoms, affected organs, and course. Am J Med 2006;119:267-274.
• Bork K, Fischer B, Dewald G. Recurrent episodes of skin angioedema and severe attacks of abdominal pain induced by
• oral contraceptives or hormone replacement therapy. Am J
• Med. 2003;114:294-298.
• Oyaizu T, Kikuchi A, Minoshima R, et al. Anesthesia for total
• hip arthroplasty in a patient with C1 inhibitor deficiency. Masui 2014;63:820-822.
• Cox M, Holdcroft A. Hereditary anjioneurotic oedema: current
• management in pregnancy. Anaesthesia 1995;50:547-549.