Alopesi areata’da IL - 6 Promotör Polimorfizmi

Year 2016, Volume: 43 Issue: 4, 484 - 489, 25.12.2016

Hacı Ömer Ateş

Abstract

Amaç: Alopesi areata (AA), T- hücre aracılı otoimmün
bir hastalıktır ve sitokinler bu hastalığın gelişiminde önemli rol
oynamaktadırlar. Önceki çalışmalar AA’lı hastaların serumlarında
proinflamatuar bir sitokin olan IL–6’nın serum seviyesinin kontrol
grubuna göre anlamlı düzeyde yüksek olduğunu göstermiştir. IL–6 geninin
promotör bölgesinde bulunan -174 G/C polimorfizmi IL–6’nın serum
seviyesini etkilemektedir. Sunulan bu çalışmanın amacı IL–6 -174 G/C
promotör polimorfizmi ile AA’nın ilişkisinin olup olmadığını
değerlendirmekti.

Yöntemler: Bu çalışmaya 146 AA’lı hasta ve 133
sağlıklı birey dahil edildi. IL–6 geni -174 G/C polimorfizminin
genotiplendirmesi Polimeraz Zincir Reaksiyonu (PZR) ve Restriksiyon
Enzim Analizi (REA) yöntemleri ile gerçekleştirildi.

Bulgular: Hasta ve kontrol grupları arasında IL–6 geni
-174 G/C promotör polimorfizminin genotip ve allel frekanslarının
dağılımı istatistiksel olarak anlamlı bulunmadı (sırasıyla, p=0.749 ve
p=0.228).

Sonuç: Bu çalışma, IL–6 -174G/C polimorfizminin AA için bir yatkınlık faktörü olmadığını göstermektedir.

Keywords

Alopesi areata, IL – 6, Otoimmünite

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