Trombositten zengin Fibrinin periferik sinir iyileşmesi üzerindeki histopatolojik etkileri

Year 2017, Volume: 44 Issue: 3, 243 - 250, 20.09.2017

Hasan Metineren Turan Cihan Dülgeroğlu Mehmet Hüseyin Metineren

https://doi.org/10.5798/dicletip.338997

Cited By: 2

Abstract

Amaç: Sinir iyileşmesini hızlandırmak ve kalitesini artırmak için çeşitli materyallerle deneysel çalışmalar yapılmıştır. Çalışmamızın amacı trombositten
zengin fibrinin (TZF) siyatik sinir iyileşmesi üzerindeki histopatolojik etkilerini
deneysel rat modelinde araştırmaktır.

Yöntemler: 16 Sprague Dawley rat randomize iki guruba (8 kontrol, 8 TZF) ayrıldı. Tüm ratların siyatik sinirleri
kesilip 2mm defektli olarak tekrar onarıldı. TZF gurubunda
defektif bölgeye TZF sarıldı. 6 haftanın sonunda ratlar
sakrifiye edilerek histolojik ve immüno-histokimyasal
metotlarla TZF nin kontrol gurubuna göre sinir onarımına
katkısı araştırıldı.

Sonuç: TZF gurubunun histolojik skorları, kontrol gurubuna göre istatistiksel olarak anlamlı bulundu(P=0.001). TZF sinirlerde aksonal devamlılık mevcuttu. Kontrol grubunda defektin tamamen iyileşmediği
yada
fibröz/granülasyon dokuyla iyileştiği gözlendi. Bol miktarda hücresel içerik ve büyüme
faktörü ihtiva eden TZF sinir iyileşmesine olumlu katkı sağlamaktadır.

Keywords

Trombositten zengin fibrin, sinir iyileşmesi, deneysel rat modeli

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