Karanlığın Mucizesi: Melatonin ve Ovaryum Etkileşimi

Year 2018, Volume: 45 Issue: 1, 85 - 92, 17.03.2018

Gökçe Nur Yücel Gülnur Take Kaplanoğlu Cemile Merve Seymen

https://doi.org/10.5798/dicletip.407249

Cited By: 5

Abstract

Başarılı bir üreme döngüsü sağlıklı aydınlık/karanlık
döngüye sahip fizyolojik koşullarla doğrudan ilişkilidir. Sirkadyan ritim olarak
da ifade edilen, bu aydınlık karanlık döngü memeli üreme sistemleri için
önemlidir. Özellikle dişi üreme döngüsü ovulasyon ve sirkadyan ritmi içeren
kompleks bir süreçtir. Bu kompleks süreçte antioksidan aktivitesiyle melatonin
çok önemli bir yere sahip olmakla birlikte, melatonin sentezleyen organ listesi
yapılan çalışmalar ışığında gün geçtikçe artmakta ve bu organların arasında
ovaryum da yer almaktadır Dolayısı ile pineal bezin yanısıraovaryumda da
melatonin sentezlendiği ve sentezlenen melatoninin foliküler sıvıya salındığı
ileri sürülmektedir. Benzer şekilde in vitrofertilizasyon (IVF) çalışmalarında
medyuma melatoninin eklenmesi ile tedavide pozitif sonuçlar elde edilmiştir. Bu
derlemede, karanlığın mucizesi olan melatoninin genel özelliklerini ve özellikle
son yıllarda yapılan çalışmalar ile ortaya konulan ovulasyon-melatonin
ilişkisini farklı yönleri ile ele almayı amaçladık.

Keywords

Melatonin, Ovaryum

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