Long-term Outcomes of Surgical Management of Insulinoma: Single Center Experience

Year 2018, Volume: 45 Issue: 2, 139 - 146, 15.06.2018

Abdullah Ulku Orcun Yalav A. Gokhan Saritas Ahmet Rencuzogullari , Kubilay Dalci İsmail Cem Eray Ozgur Yagmur Atılgan Tolga Akcam

https://doi.org/10.5798/dicletip.424975

Cited By: 1

Abstract

Objective:
Limited data are available in regards to the surgical management and outcomes
of insulinoma. This study aimed to assess the outcomes associated with surgical
treatment of insulinoma, as the most common pancreatic endocrine tumor.

Methods:
Medical records of patients who diagnosed as insulinoma from 2000 to 2010 at
General Surgery Department of Cukurova University Hospital were retrospectively
reviewed. Surgical treatment (resection vs. enucleation) was based on
preoperative radiological investigations (abdominal spiral contrast tomography,
ultrasound, selective angiography for selected cases) and intra-operative
ultrasound imaging once indicated.

Results:
Surgically treated thirteen patients (F/M:9/4) who diagnosed with insulinoma
were assessed with a mean follow-up of 5.3 (0.5-10) years. Enucleation and
distal pancreatectomy were performed for 11 and 2 (one of those is
spleen-preserving) patients, respectively. No mortality was recorded. All
patients became normoglycemic after surgery without re-operation and with
acceptable complication rates (n=3 pancreatic fistula, n=1 pancreatitis).

Conclusion:
Surgical treatment of insulinoma is associated with favorable outcomes. Intra-operative
ultrasound with manual palpation is still the gold standard for localizing
insulinoma. Location, size and relationship with main pancreatic duct of the
lesions are key components for the selection of optimal surgical procedure.

Keywords

insulinoma; surgical treatment; enucleation; pancreatic endocrine tumor.

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