Association with Platelet Distribution Width and New-Onset Atrial Fibrillation After Coronary Artery Bypass Grafting

Year 2018, Volume: 45 Issue: 3, 309 - 316, 05.09.2018

Ferhat Özyurtlu , Gökhan Albayrak

https://doi.org/10.5798/dicletip.457254

Cited By: 1

Abstract

Objective:
The platelet distribution width (PDW) is one of the parameters of platelet
activation. The PDW directly measures the variability in platelet size. However,
there has been a limited number of data reported thus far on PDW and
postoperative AF in patients undergoing CABG. We aimed to investigate the
relationship between the PDW and postoperative AF in patients undergoing CABG.

Methods:
124 consecutive patients with sinus rhythm who had undergone CABG between July
2011 and December 2013 were evaluated. AF was defined as any episode of AF
lasting longer than 30 seconds. Complete blood count samples were analyzed
according to the results obtained within 48 hours of the preoperative and
postoperative period. 

Results:
The preoperative PDW levels were significantly lower in patients who had
developed AF than in the control group (56.5±14.8 vs. 50.9±10.0, p=0.015).
There was no correlation between the postoperative PDW levels and AF. The
preoperative white blood cell (WBC) and the neutrophil/lymphocyte ratio (NLR)
were found to be similar between the two groups, while the postoperative WBC
(13.9±5.7 vs. 10.5±3.6, p=0.000) and NLR (14.4±9.4 vs. 9.0±8.4, p: 0. 001)
levels were higher in the group of patients who had AF. An NLR of 8.5 predicted
post-CABG AF with a sensitivity of 73% and a specificity of 63%, and a WBC of
10 predicted post-CABG AF with a sensitivity of 77% and a specificity of 48%. 

Conclusion:
These results support the hypothesis that preoperative PDW level predicts
new-onset AF after CABG, but suggest that other factors are also important.

Keywords

Atrial fibrillation, coronary artery bypass surgery, platelet distribution width, white blood cell

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