Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu

Seval Erpolat; Zehra Arslanyılmaz; İkbal Kaygusuz

Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu

Year 2016, Volume: 43 Issue: 2, 310 - 314, 01.06.2016

Seval Erpolat Zehra Arslanyılmaz İkbal Kaygusuz

Abstract

Amaç: Akne vulgaris adölesan ve genç erişkinleri etkileyen
en yaygın deri hastalığıdır. Çinko insanlar için esansiyel
bir elementtir. Bazı çalışmalarda serum çinko seviyeleri
ve akne vulgaris arasında bir ilişki raporlanmıştır.
Bu çalışmamızın amacı akne vulgarisli hastalarda serum
çinko düzeyini ölçmek ve bunun akne şiddetiyle korelasyonunu
değerlendirmektir.
Yöntemler: 43 akne vulgaris hastası ve 37 sağlıklı gönüllü
çalışmaya alındı. Hasta grubunda Global Akne Derecelendirme
Sistemine (GADS) göre akne şiddeti belirlendi.
Serum Çinko düzeyleri hasta ve kontrol grubunda ölçüldü.
Bulgular: Aknesi olan hastalarda çinko düzeyi 81.48 ±
14.21 µg/dl, kontrol grubunda 83,69 ± 12,43 µg/dl olarak
tespit edildi, çinko düzeyi açısından gruplar arasında istatistiksel
olarak anlamlı bir farklılık izlenmedi (p=0,46).
Aknesi olan hastaların akne şiddeti ile çinko düzeyleri
arasında negatif korelasyon tespit edildi ama istatistiksel
olarak anlamlılık izlenmedi (r=-0,024, p=0,88)
Sonuç: Bizim sonuçlarımız serum çinko düzeyleri ile
akne şiddeti arasında herhangi bir ilişki olmadığını göstermektedir.
Daha ileri çalışmalar gerekmektedir.

Keywords

Akne vulgaris, çinko, hastalık şiddeti

References

1. Jappe U. Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy. Acta Derm Venereol 2003;83:241-248.
2. Dreno B, Poli F. Epidemiology of acne. Dermatology 2003;206:7-10.
3. Akyazı H, Baltacı D, Alpay K, et al. Quality of life in adult patients with acne vulgaris before and after treatment. Dicle Med J 2011;38:282-288.
4. Aydemir EH. Akne vulgaris . Türk Ped Arş 2014;49:13-16.
5. Bowe WP, Joshi SS, Shalita AR. Diet and acne. J Am Acad Dermatol 2010;63:124-141.
6. Norris D. Zinc and cutaneous inflammation. Arch Dermatol 1985;121:985-987.
7. Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatol Surg 2005;31:837-847.
8. Krause-Jarres JD. Pathogenesis and symptoms of zinc deficiency. Am Clin Lab 2001;20:17-22.
9. Saner G. Mikroelementler (Çinko). Neyzi O, Ertuğrul T, Pediatri 2002; 1. Cilt, 3. Baskı, İstanbul, 174-175.
10. Brocard A, Dréno B. Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis. J Eur Acad Dermatol Venereol 2011;25:1146-1152.
11. Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997;36:416-418.
12. Igic PG, Lee E, Harper W, et al. Toxic effects associated with consumption of zinc. Mayo Clin Proc 2002;77:713- 716.
13. Smith JE, Brown ED, Smith JC. The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat. J Lab Clin Med 1974;84:692- 697.
14. Sansone G, Reisner RM. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin, a possible pathogenic factor in acne. J Invest Dermatol 1971; 26: 366-372.
15. Michaelsson G, Juhlin L, Vahlquist A. Effects of oral zinc and vitamin A in acne. Arch Dermatol 1977;57:357-360.
16. Amer M, Bahgat MR, Tosson Z, et al. Serum zinc in acne vulgaris. Int J Dermatol 1982;21:481-484.
17. Nasiri S, Ghalamkarpour F, Yousefi M, et al. Serum zinc levels in Iranian patients with acne. Clin Exp Dermatol 2009;34: e446.
18. Saleh BO, Z Anbar ZNH, Majid AY. Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients. J Clin Exp Dermatol Res 2013; 4:169.
19. Ozuguz P, Dogruk Kacar S, Ekiz O, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris.Cutan Ocul Toxicol 2014;33:99- 102.
20. El-Saaiee L, Abdel-Aal H, El-Mahdy H, et al. Serum copper, iron and zinc in cases of acne vulgaris. J Med 1983;14:125- 136
21. Cochran RJ, Tucker SB, Flannigan SA. Topical zinc therapy for acne vulgaris. Int J Dermatol 1985;24:188-190.

Serum Zinc Levels in Patients with Acne Vulgaris and Its Correlation with Severity of Acne

Year 2016, Volume: 43 Issue: 2, 310 - 314, 01.06.2016

Seval Erpolat Zehra Arslanyılmaz İkbal Kaygusuz

Abstract

Objective: Acne vulgaris the most common cutaneous disorder affecting adolescent and young adults. Zinc is an essential element for human. We aimed to evaluate the serum zinc level in patients with acne vulgaris and correlate with the severity of disease. Methods: The study included 43 patients with acne vulgaris and 37 healthy control subjects. The severity of acne was assessed according to Global Acne Grading System. The serum zinc levels were measured both patients and control subjects. Results: The serum zinc level in acne patients were 81.48 ± 14.21 μg/dl and 83.69 ± 12.43 μg/dl in control subjects. There was no statistically significant difference between patients and control subjects (p=0.46).There was a negative correlation between acne severity and serum zinc levels but there was no statistically significant (r=-0.024, p=0.88). Conclusion: The results of our study revealed no relation between serum zinc levels and acne. Further studies are needed.

Keywords

Acne vulgaris, zinc, severity of the disease

References

1. Jappe U. Pathological mechanisms of acne with special emphasis on Propionibacterium acnes and related therapy. Acta Derm Venereol 2003;83:241-248.
2. Dreno B, Poli F. Epidemiology of acne. Dermatology 2003;206:7-10.
3. Akyazı H, Baltacı D, Alpay K, et al. Quality of life in adult patients with acne vulgaris before and after treatment. Dicle Med J 2011;38:282-288.
4. Aydemir EH. Akne vulgaris . Türk Ped Arş 2014;49:13-16.
5. Bowe WP, Joshi SS, Shalita AR. Diet and acne. J Am Acad Dermatol 2010;63:124-141.
6. Norris D. Zinc and cutaneous inflammation. Arch Dermatol 1985;121:985-987.
7. Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatol Surg 2005;31:837-847.
8. Krause-Jarres JD. Pathogenesis and symptoms of zinc deficiency. Am Clin Lab 2001;20:17-22.
9. Saner G. Mikroelementler (Çinko). Neyzi O, Ertuğrul T, Pediatri 2002; 1. Cilt, 3. Baskı, İstanbul, 174-175.
10. Brocard A, Dréno B. Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis. J Eur Acad Dermatol Venereol 2011;25:1146-1152.
11. Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997;36:416-418.
12. Igic PG, Lee E, Harper W, et al. Toxic effects associated with consumption of zinc. Mayo Clin Proc 2002;77:713- 716.
13. Smith JE, Brown ED, Smith JC. The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat. J Lab Clin Med 1974;84:692- 697.
14. Sansone G, Reisner RM. Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin, a possible pathogenic factor in acne. J Invest Dermatol 1971; 26: 366-372.
15. Michaelsson G, Juhlin L, Vahlquist A. Effects of oral zinc and vitamin A in acne. Arch Dermatol 1977;57:357-360.
16. Amer M, Bahgat MR, Tosson Z, et al. Serum zinc in acne vulgaris. Int J Dermatol 1982;21:481-484.
17. Nasiri S, Ghalamkarpour F, Yousefi M, et al. Serum zinc levels in Iranian patients with acne. Clin Exp Dermatol 2009;34: e446.
18. Saleh BO, Z Anbar ZNH, Majid AY. Role of Some Trace Elements in Pathogenesis and Severity of Acne Vulgaris in Iraqi Male Patients. J Clin Exp Dermatol Res 2013; 4:169.
19. Ozuguz P, Dogruk Kacar S, Ekiz O, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris.Cutan Ocul Toxicol 2014;33:99- 102.
20. El-Saaiee L, Abdel-Aal H, El-Mahdy H, et al. Serum copper, iron and zinc in cases of acne vulgaris. J Med 1983;14:125- 136
21. Cochran RJ, Tucker SB, Flannigan SA. Topical zinc therapy for acne vulgaris. Int J Dermatol 1985;24:188-190.

There are 21 citations in total.

Details

Other ID	JA63BN69GC
Journal Section	Research Article
Authors	Seval Erpolat This is me Zehra Arslanyılmaz This is me İkbal Kaygusuz This is me
Publication Date	June 1, 2016
Submission Date	June 1, 2016
Published in Issue	Year 2016 Volume: 43 Issue: 2

Cite

APA	Erpolat, S., Arslanyılmaz, Z., & Kaygusuz, İ. (2016). Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu. Dicle Tıp Dergisi, 43(2), 310-314.
AMA	Erpolat S, Arslanyılmaz Z, Kaygusuz İ. Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu. diclemedj. June 2016;43(2):310-314.
Chicago	Erpolat, Seval, Zehra Arslanyılmaz, and İkbal Kaygusuz. “Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri Ve Akne Şiddetiyle Korelasyonu”. Dicle Tıp Dergisi 43, no. 2 (June 2016): 310-14.
EndNote	Erpolat S, Arslanyılmaz Z, Kaygusuz İ (June 1, 2016) Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu. Dicle Tıp Dergisi 43 2 310–314.
IEEE	S. Erpolat, Z. Arslanyılmaz, and İ. Kaygusuz, “Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu”, diclemedj, vol. 43, no. 2, pp. 310–314, 2016.
ISNAD	Erpolat, Seval et al. “Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri Ve Akne Şiddetiyle Korelasyonu”. Dicle Tıp Dergisi 43/2 (June 2016), 310-314.
JAMA	Erpolat S, Arslanyılmaz Z, Kaygusuz İ. Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu. diclemedj. 2016;43:310–314.
MLA	Erpolat, Seval et al. “Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri Ve Akne Şiddetiyle Korelasyonu”. Dicle Tıp Dergisi, vol. 43, no. 2, 2016, pp. 310-4.
Vancouver	Erpolat S, Arslanyılmaz Z, Kaygusuz İ. Akne Vulgarisli Hastalarda Serum Çinko Düzeyleri ve Akne Şiddetiyle Korelasyonu. diclemedj. 2016;43(2):310-4.