Uric acid levels in metabolically healthy and unhealthy obese patients

Year 2014, Volume: 41 Issue: 4, 676 - 680, 01.12.2014

Emin Murat Akbaş Adalet Özçiçek Fatih Özçiçek Levent Demirtaş Aysu Timuroğlu Adem Güngör Nergis Akbaş

https://doi.org/10.5798/diclemedj.0921.2014.04.0498

Abstract

Objective: In this study, we aimed to investigate the difference of uric acid levels between metabolically healthy and unhealthy obese individuals. Methods: Patients of internal medicine and endocrinology outpatient clinics who admitted with the complaint of overweight were separated into two groups, by diagnostic criteria for metabolic syndrome, as metabolically healthy obese and metabolically unhealthy obese individuals. Total of 193 women aged between 18 to 70 years were enrolled into study. Results: Statistically significant differences were determined regarding waist circumference (p=0.038), HOMA-IR (p0.05) were not differ between these groups. When patients were separated into two groups according to uric acid median, the rate of metabolic syndrome found to be increased in high uric acid group (p=0.021). A correlation analysis showed that uric acid was significantly associated with number of metabolic syndrome parameters (r=0.270, p

Keywords

Uric acid, obesity, metabolic syndrome X

Metabolik olarak sağlıklı ve sağlıksız obez hastalarda ürik asit seviyeleri

Abstract

Amaç: Çalışmamızda, metabolik olarak sağlıklı ve sağlıksız obez bireyler arasında serum ürik asit seviyelerindeki farkların araştırılması amaçlanmıştır. Yöntemler: Çalışmamızda; hastanemiz iç hastalıkları ve endokrinoloji polikliniklerine kilo fazlalığı şikayeti ile başvuran hastalarda, metabolik sendrom tanı kriterleri araştırılarak, metabolik olarak sağlıklı obezler ve sağlıksız obezler olarak iki grup oluşturuldu. Çalışmaya yaşları 18 ile 70 arasında değişen, toplam 193 kadın katılımcı alındı. Bulgular: Metabolik olarak sağlıklı obezler ve metabolik olarak sağlıksız obezler arasında bel çevresi (p=0,038), HOMA-IR (p0,05). Hastalar ürik asit median değerine göre iki gruba ayrıldığında, ürik asit yüksek grupta, metabolik sendrom rastlanma oranının arttığı tespit edildi (p=0,021). Metabolik sendrom ile ilişkisinin yanında, ürik asidin, korelasyon analizinde, metabolik sendrom kriterlerinin sayısı ile de anlamlı ilişki tespit edildi (r=0,270, p

Keywords

Ürik asit, obezite, metabolik sendrom X

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