BibTex RIS Cite

Clinical and demographic characteristics of 165 patients with lichen planus

Year 2014, Volume: 41 Issue: 1, 78 - 81, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0376

Abstract

Objective: Lichen planus (LP), is a papulosquamous inflammatory disease, which involves the skin, mucous membranes, nails and scalp. The incidence varies according to geographical regions. In this study, it was aimed to detect the clinical and demographic characteristics of the patients with LP who have been under follow-up at our clinic. Methods: One hundred sixty five patients, who were diagnosed as LP in our clinic between 2010 and 2013, were enrolled to the study. The age, gender, disease duration, time of onset of disease, characteristics of involvement, associated systemic diseases, laboratory findings and treatment were recorded retrospectively. Results: In our study, 0.6% of all patients admitted to our clinic were diagnosed as LP. A total of 165 patients included in the study, 92 women (56%) and 73 men (44%), respectively. Patients\' ages ranged 8-78 (mean 44.7±16.7). Disease duration ranged from 1 month to 20 years (mean 15.6±29.7). One hundred thirty four patients (81.2%) had skin involvement, 51 (31%) had oral mucosal involvement, and 15 (9%) had genital involvement. Five (4.5%) of 111 patients with viral hepatitis tests were positive for hepatitis C virus. Hepatitis B virus positivity was seen in 4 (4%) patients. Conclusion: There is a need for further studies with more patients to better understand the epidemiological, clinical and pathological characteristics of LP. We believe that our study will contribute to the determination of our country\'s data.

References

  • İnalöz S. Liken Planus ve Likenoid Erüpsiyonlar. In: Tüzün Y, Gürer MA, Serdaroğlu S, Oğuz O, Aksungur V, eds. Dermatoloji, 3.cü baskı İstanbul, Nobel Tıp Kitabevleri, 2008:765-798.
  • Pittelkow MR, Daoud MS. Lichen Planus. In: Wolff K, Gold- smith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, eds. Fitzpatricks’s Dermatology in General Medicine. 7th eds. New York, McGraw-Hill, 2008:244-255.
  • Van der Meij EH, Mast H, Van der Waal I. The possible pre- malignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 pa- tients. Oral Oncol 2007;43:742-748.
  • Kaplan B, Barnes L. Oral lichen planus and squamous carci- noma. Case report and update of the literature. Arch Otolar- yngol 1985;111:543-547.
  • Boyd AS, Neldner KH. Lichen planus. J Am Acad Dermatol 1991;25:593-619.
  • Yanık ME, Aliağaoğlu C, Turan H, et al. Son 10 yılda kliniğimizde takip edilen liken planus olgularının retrospe- ktif değerlendirilmesi. Tıp Araştırmaları Dergisi 2012;10:6- 11.
  • Schmidt H. Frequency, duration and localisation of lichen planus. A study based on 181 patients. Acta Derm Venereol 1961;41:164-167.
  • Al Robaee AA, Al Zolibani AA. Oral lichen planus and hepa- titis C virus: is there real association? Acta Dermatovenerol Alp Panonica Adriat 2006;15:14-19.
  • Karavelioğlu D, Koytak ES, Bozkaya H, et al. Lichen planus and HCV infection in Turkish patients. Turk J Gastroenterol 2004;15:133-136.
  • Denli YG, Durdu M, Karakas M. Diabetes and hepatitis fre- quency in 140 lichen planus cases in Cukurova region. J Dermatol 2004;31:293-298.
  • Harman M, Akdeniz S, Dursun M, et al. Lichen planus and hepatitis C virus infection: an epidemiologic study. Int J Clin Pract 2004;58:1118-1119.
  • Kirtak N, Inalöz HS, Ozgöztasi, et al. The prevalence of hepatitis C virus infection in patients with lichen planus in Gaziantep region of Turkey. Eur J Epidemiol 2000;16:1159- 1161.
  • Nagao Y, Kameyama T, Sata M. Hepatitis C virus RNA detection in oral lichen planus tissue. Am J Gastroenterol 1998;93:850.
  • Gruppo Italiano Studi Epidemiologica in Dermatologia (GISED): Lichen planus and liver disease: A multicentre case-control study. BMJ 1990;300:227-230.
  • Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol 2002;46:207-214.
  • Lowe NJ, Cudwoth AG, Clough SA, et al. Carbohydrate metabolism in lichen planus. Br J Dermatol 1976;95:9-12.
  • Powell SM, Ellis JP, Ryan TJ, et al. Glucose tolerance in lichen planus. Br J Dermatol 1974;91:73-75.

Clinical and demographic characteristics of 165 patients with lichen planus

Year 2014, Volume: 41 Issue: 1, 78 - 81, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0376

Abstract

Amaç: Liken planus (LP) deri, muköz membranlar, tırnaklar ve saçlı deriyi tutabilen papuloskuamöz inflamatuar bir hastalıktır. İnsidansı coğrafik bölgelere göre farklılık göstermektedir. Bu çalışmada kliniğimizde LP tanısı ile takip edilen hastaların klinik ve demografik özelliklerinin saptanması amaçlanmıştır. Yöntemler: Çalışmamıza 2010 ile 2013 yılları arasında polikliniğimizde LP tanısı konulan 165 hasta alındı. Hastaların yaş, cinsiyet, hastalık süresi, hastalık başlangıç zamanı, tutulum özelliği, ek sistemik hastalıkları, laboratuvar bulguları ve uygulanan tedavileri retrospektif olarak kaydedildi. Bulgular: Çalışmamızda polikliniğimize başvuran tüm hastaların %0,6\'sının LP tanısı aldığı görüldü. Çalışmaya alınan toplam 165 hastanın 92\'si kadın (%56), 73\'ü erkek (%44) idi. Hastaların yaşları 8-78 (ortalama 44,7±16,7) arasındaydı. Hastalık süreleri 1 ay ile 20 yıl arasında değişiyordu (ortalama 15,6±29,7). Hastaların 134\'ünde (%81) deri tutulumu, 51\'inde (%31) oral mukoza tutulumu ve 15\'inde (%9) genital tutulum saptandı. Viral hepatit tetkikleri yapılan 111 hastanın beşinde (%4,5) hepatit C virüs pozitifliği saptandı. Hepatit B virüs pozitifliği ise 4 (%4) hastada görüldü. Sonuç: LP\'un epidemiyolojik, klinik ve patogenetik özelliklerinin tam olarak anlaşılabilmesi için daha çok hasta ile yapılacak ileri çalışmalara ihtiyaç duyulmaktadır. Çalışmamızın bu açıdan ülkemize ait verilerin oluşmasına katkıda bulunacağını düşünmekteyiz.

References

  • İnalöz S. Liken Planus ve Likenoid Erüpsiyonlar. In: Tüzün Y, Gürer MA, Serdaroğlu S, Oğuz O, Aksungur V, eds. Dermatoloji, 3.cü baskı İstanbul, Nobel Tıp Kitabevleri, 2008:765-798.
  • Pittelkow MR, Daoud MS. Lichen Planus. In: Wolff K, Gold- smith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, eds. Fitzpatricks’s Dermatology in General Medicine. 7th eds. New York, McGraw-Hill, 2008:244-255.
  • Van der Meij EH, Mast H, Van der Waal I. The possible pre- malignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 pa- tients. Oral Oncol 2007;43:742-748.
  • Kaplan B, Barnes L. Oral lichen planus and squamous carci- noma. Case report and update of the literature. Arch Otolar- yngol 1985;111:543-547.
  • Boyd AS, Neldner KH. Lichen planus. J Am Acad Dermatol 1991;25:593-619.
  • Yanık ME, Aliağaoğlu C, Turan H, et al. Son 10 yılda kliniğimizde takip edilen liken planus olgularının retrospe- ktif değerlendirilmesi. Tıp Araştırmaları Dergisi 2012;10:6- 11.
  • Schmidt H. Frequency, duration and localisation of lichen planus. A study based on 181 patients. Acta Derm Venereol 1961;41:164-167.
  • Al Robaee AA, Al Zolibani AA. Oral lichen planus and hepa- titis C virus: is there real association? Acta Dermatovenerol Alp Panonica Adriat 2006;15:14-19.
  • Karavelioğlu D, Koytak ES, Bozkaya H, et al. Lichen planus and HCV infection in Turkish patients. Turk J Gastroenterol 2004;15:133-136.
  • Denli YG, Durdu M, Karakas M. Diabetes and hepatitis fre- quency in 140 lichen planus cases in Cukurova region. J Dermatol 2004;31:293-298.
  • Harman M, Akdeniz S, Dursun M, et al. Lichen planus and hepatitis C virus infection: an epidemiologic study. Int J Clin Pract 2004;58:1118-1119.
  • Kirtak N, Inalöz HS, Ozgöztasi, et al. The prevalence of hepatitis C virus infection in patients with lichen planus in Gaziantep region of Turkey. Eur J Epidemiol 2000;16:1159- 1161.
  • Nagao Y, Kameyama T, Sata M. Hepatitis C virus RNA detection in oral lichen planus tissue. Am J Gastroenterol 1998;93:850.
  • Gruppo Italiano Studi Epidemiologica in Dermatologia (GISED): Lichen planus and liver disease: A multicentre case-control study. BMJ 1990;300:227-230.
  • Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol 2002;46:207-214.
  • Lowe NJ, Cudwoth AG, Clough SA, et al. Carbohydrate metabolism in lichen planus. Br J Dermatol 1976;95:9-12.
  • Powell SM, Ellis JP, Ryan TJ, et al. Glucose tolerance in lichen planus. Br J Dermatol 1974;91:73-75.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Bilge Bülbül Şen This is me

Özlem Ekiz This is me

Emine Nur Rifaioğlu This is me

Mehmet Uğur İnan This is me

Asena Çiğdem Doğramacı This is me

Publication Date March 1, 2014
Submission Date March 2, 2015
Published in Issue Year 2014 Volume: 41 Issue: 1

Cite

APA Şen, B. B., Ekiz, Ö., Rifaioğlu, E. N., İnan, M. U., et al. (2014). Clinical and demographic characteristics of 165 patients with lichen planus. Dicle Medical Journal, 41(1), 78-81. https://doi.org/10.5798/diclemedj.0921.2014.01.0376
AMA Şen BB, Ekiz Ö, Rifaioğlu EN, İnan MU, Doğramacı AÇ. Clinical and demographic characteristics of 165 patients with lichen planus. diclemedj. March 2014;41(1):78-81. doi:10.5798/diclemedj.0921.2014.01.0376
Chicago Şen, Bilge Bülbül, Özlem Ekiz, Emine Nur Rifaioğlu, Mehmet Uğur İnan, and Asena Çiğdem Doğramacı. “Clinical and Demographic Characteristics of 165 Patients With Lichen Planus”. Dicle Medical Journal 41, no. 1 (March 2014): 78-81. https://doi.org/10.5798/diclemedj.0921.2014.01.0376.
EndNote Şen BB, Ekiz Ö, Rifaioğlu EN, İnan MU, Doğramacı AÇ (March 1, 2014) Clinical and demographic characteristics of 165 patients with lichen planus. Dicle Medical Journal 41 1 78–81.
IEEE B. B. Şen, Ö. Ekiz, E. N. Rifaioğlu, M. U. İnan, and A. Ç. Doğramacı, “Clinical and demographic characteristics of 165 patients with lichen planus”, diclemedj, vol. 41, no. 1, pp. 78–81, 2014, doi: 10.5798/diclemedj.0921.2014.01.0376.
ISNAD Şen, Bilge Bülbül et al. “Clinical and Demographic Characteristics of 165 Patients With Lichen Planus”. Dicle Medical Journal 41/1 (March 2014), 78-81. https://doi.org/10.5798/diclemedj.0921.2014.01.0376.
JAMA Şen BB, Ekiz Ö, Rifaioğlu EN, İnan MU, Doğramacı AÇ. Clinical and demographic characteristics of 165 patients with lichen planus. diclemedj. 2014;41:78–81.
MLA Şen, Bilge Bülbül et al. “Clinical and Demographic Characteristics of 165 Patients With Lichen Planus”. Dicle Medical Journal, vol. 41, no. 1, 2014, pp. 78-81, doi:10.5798/diclemedj.0921.2014.01.0376.
Vancouver Şen BB, Ekiz Ö, Rifaioğlu EN, İnan MU, Doğramacı AÇ. Clinical and demographic characteristics of 165 patients with lichen planus. diclemedj. 2014;41(1):78-81.