Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori

Baran Gencer; Fahri Güneş; Yusuf Ziya Tan; Erdem Akbal; Hasan Ali Tufan; Yeliz Ekim; Hacer Şen; Arzu Taşkıran Çömez; Semra Özdemir; Selçuk Kara

doi:10.5798/diclemedj.0921.2014.01.0377

Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori

Year 2014, Volume: 41 Issue: 1, 82 - 85, 01.03.2014

Baran Gencer Fahri Güneş Yusuf Ziya Tan Erdem Akbal Hasan Ali Tufan Yeliz Ekim Hacer Şen Arzu Taşkıran Çömez Semra Özdemir Selçuk Kara

https://doi.org/10.5798/diclemedj.0921.2014.01.0377

Abstract

Objectives: High prevalence of Helicobacter pylori (HP) in the glaucoma patients was shown in recent studies. In our prospective study we aimed to compare the intraocular pressure (IOP) and the retinal nerve fiber layer thickness (RNFLT) in patients with HP positive and negative. Methods: In 91 patients with gastritis HP was investigated by urea breath test (UBT) and biopsy sample culture Following the full ophthalmologic examination the patients\' IOP was measured by Goldmann applanation tonometry and RNFLT was measured by spectral optic coherence tomography. The patients' demographic and clinical characteristics were compared with the χ² test for categorical variables and with the Mann Whitney U test for continuous variables. Results: Of the 90 patients who meet the including criteria, HP was detected in 74 patients (27 male, 47 female) positive, and in 16 patients (7 male, 9 female) negative. Median (minimum-maximum) age values were 46 (18-79) in HP positive group and 51 (18-67) in HP negative group. One hundred forty seven eyes in 74 HP positive patients and 31 eyes in 16 HP negative patients included in the study. Median IOP values were determined 14 (7-21) mmHg in HP positive group and 14 (8-18) mmHg in HP negative group. The measurements of RNFLT in superior, temporal, inferior and nasal quadrants found to be respectively 122(98-165), 68(50-101), 135(93-188), 79(51-120) micron in HP positive group and 120(94-161), 67(43-104), 129(94-166), 76(50-97) micron in HP negative group. No statistically significant difference was found when compared IOP and RNFLT measurements between the two groups (p

Keywords

Helicobacter pylori, glaucoma, intraocular pressure, retinal nerve fiber layer thickness.

References

Fechtner RD, Weinreb RN. Mechanisms of optic nerve dam- age in primary open angle glaucoma. Surv Ophthalmol 1994;39:23–42.
Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004;363:1711–1720.
Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 1989;107:453–464.
Nakatani Y, Higashide T, Ohkubo S, et al. Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography. J Glaucoma 2011;20:252-259.
Kountouras J, Mylopoulos N, Boura P, et al. Relationship be- tween Helicobacter pylori infection and glaucoma. Ophthal- mology 2001;108:599-604.
Kountouras J, Mylopoulos N, Konstas AG, et al. Increased lev- els of Helicobacter pylori IgG antibodies in aqueous humor of patients with primary open-angle and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol 2003;241:884-890.
Deshpande N, Lalitha P, Krishna das SR, et al. Helicobacter py- lori IgG antibodies in aqueous humor and serum of subjects with primary open angle and pseudo-exfoliation glaucoma in a South Indian population. J Glaucoma 2008;17:605-610.
Zavos C, Kountouras J, Sakkias G, et al. Histological presence of Helicobacter pylori bacteria in the trabeculum and iris of patients with primary open-angle glaucoma. Ophthalmic Res 2012;47:150-156.
Tünger Ö. Helikobakter Pylori İnfeksiyonları. İnfeksiyon Der- gisi (Turkish Journal Of Infection) 2008;22:107-115.
Cotticelli L, Borrelli M, D’Alessio AC, et al. Central serous chorioretinopathy and Helicobacter pylori. Eur J Ophthalmol 2006;16:274-278.
Saccà SC, Pascotto A, Venturino GM, et al. Prevalence and treatment of Helicobacter pylori in patients with blepharitis. Invest Ophthalmol Vis Sci 2006;47:501-508.
Kim JM, Kim SH, Park KH, et al. Investigation of the associa- tion between Helikobakter pilori infection and normal tension glaucoma. Invest Ophthalmol Vis Sci 2011;52:665-668.
Kountouras J, Mylopoulos N, Chatzopoulos D, et al. Eradi- cation of Helicobacter pylori may be beneficial in the man- agement of chronic open-angle glaucoma. Arch Intern Med 2002;162:1237-1244.
Kountouras J, Zavos C, Chatzopoulos D. Induction of apoptosis as a proposed pathophysiological link between glaucoma and Helikobakter pilori infection. Med Hypotheses 2004;62:378- 381.
Galloway PH, Warner SJ, Morshed MG, Mikelberg FS. Helico- bacter pylori infection and the risk for open-angle glaucoma. Ophthalmology 2003;110:922-925.
Kurtz S, Regenbogen M, Goldiner I, et al. No association be- tween Helicobacter pylori infection or CagA-bearing strains and glaucoma. J Glaucoma 2008;17:223-226.
Zullo A, Ridola L, Hassan C, et al. Glaucoma and Helicobacter pylori: eyes wide shut? Dig Liver Dis 2012;44:627-628.

Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori

Year 2014, Volume: 41 Issue: 1, 82 - 85, 01.03.2014

Baran Gencer Fahri Güneş Yusuf Ziya Tan Erdem Akbal Hasan Ali Tufan Yeliz Ekim Hacer Şen Arzu Taşkıran Çömez Semra Özdemir Selçuk Kara

https://doi.org/10.5798/diclemedj.0921.2014.01.0377

Abstract

Amaç: Glokom olgularında Helikobakter pilori (HP) prevalansının yüksek olduğu geçmiş çalışmalarda gösterilmiştir. Prospektif çalışmamızda HP pozitif ve negatif olguların göz içi basınç (GİB) ve retina sinir lifi tabakası kalınlık (RSLTK) ölçümlerini karşılaştırmayı amaçladık. Yöntemler: Gastrit bulguları olan 91 hastada HP varlığı üre nefes testi veya gastrik biyopsi ile araştırıldı. Hastaların tam oftalmolojik muayeneleri takiben GİB\'ı Goldmann aplanasyon tonometresi ve RSLTK\'ı spektral optik koherens tomografi ile ölçüldü. Hastaların demografik ve klinik özellikleri kategorik değişkenler için χ² testi ve sürekli değişkenler için Mann Whitney U testi ile karşılaştırıldı. Bulgular: Çalışma kriterlerine uyan 74 hastada (27 erkek, 47 kadın) HP pozitif ve 16 hastada (7 erkek, 9 kadın) ise HP negatif olarak saptandı. Ortanca (minimum-maksium) yaş değerleri HP pozitif grup için 46 (18-79) ve HP negatif grup için 51 (18-67) idi. HP pozitif 74 hastanın 147 gözü ve HP negatif 16 hastanın 31 gözü çalışmaya dahil edildi. GİB ortanca değerleri HP pozitif grupta 14 (7-21) mmHg ve HP negatif grupta 14 (8-18) mmHg olarak saptandı. Üst, temporal, alt ve nazal kadranlarda ölçülen RSLTK\'ların ortanca değerleri HP pozitif grupta sırasıyla 122(98-165), 68(50-101), 135(93-188), 79(51-120) mikron ve HP negatif grupta ise sırasıyla 120(94-161), 67(43-104), 129(94-166), 76(50-97) mikron olarak bulundu. İki grup arasında GİB ve RSLTK ölçümleri karşılaştırıldığında aralarında istatiksel anlamlı fark olmadığı görüldü (p>0,05). Sonuç: Bu çalışmada HP pozitif olguların GİB ve RSLTK ölçümlerinin HP negatif olgu grubuna göre anlamlı farklılık göstermediği bulundu. Glokom ile HP arasında ilişki olduğunu göstermek için geniş olgu serilerinde randomize vaka kontrollü histolojik ve serolojik çalışmaların yapılması gerekmektedir.

Keywords

Helikobakter pilori, glokom, göz içi basıncı, retina sinir lifi tabakası kalınlığı

References

Fechtner RD, Weinreb RN. Mechanisms of optic nerve dam- age in primary open angle glaucoma. Surv Ophthalmol 1994;39:23–42.
Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet 2004;363:1711–1720.
Quigley HA, Dunkelberger GR, Green WR. Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma. Am J Ophthalmol 1989;107:453–464.
Nakatani Y, Higashide T, Ohkubo S, et al. Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using spectral domain optical coherence tomography. J Glaucoma 2011;20:252-259.
Kountouras J, Mylopoulos N, Boura P, et al. Relationship be- tween Helicobacter pylori infection and glaucoma. Ophthal- mology 2001;108:599-604.
Kountouras J, Mylopoulos N, Konstas AG, et al. Increased lev- els of Helicobacter pylori IgG antibodies in aqueous humor of patients with primary open-angle and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol 2003;241:884-890.
Deshpande N, Lalitha P, Krishna das SR, et al. Helicobacter py- lori IgG antibodies in aqueous humor and serum of subjects with primary open angle and pseudo-exfoliation glaucoma in a South Indian population. J Glaucoma 2008;17:605-610.
Zavos C, Kountouras J, Sakkias G, et al. Histological presence of Helicobacter pylori bacteria in the trabeculum and iris of patients with primary open-angle glaucoma. Ophthalmic Res 2012;47:150-156.
Tünger Ö. Helikobakter Pylori İnfeksiyonları. İnfeksiyon Der- gisi (Turkish Journal Of Infection) 2008;22:107-115.
Cotticelli L, Borrelli M, D’Alessio AC, et al. Central serous chorioretinopathy and Helicobacter pylori. Eur J Ophthalmol 2006;16:274-278.
Saccà SC, Pascotto A, Venturino GM, et al. Prevalence and treatment of Helicobacter pylori in patients with blepharitis. Invest Ophthalmol Vis Sci 2006;47:501-508.
Kim JM, Kim SH, Park KH, et al. Investigation of the associa- tion between Helikobakter pilori infection and normal tension glaucoma. Invest Ophthalmol Vis Sci 2011;52:665-668.
Kountouras J, Mylopoulos N, Chatzopoulos D, et al. Eradi- cation of Helicobacter pylori may be beneficial in the man- agement of chronic open-angle glaucoma. Arch Intern Med 2002;162:1237-1244.
Kountouras J, Zavos C, Chatzopoulos D. Induction of apoptosis as a proposed pathophysiological link between glaucoma and Helikobakter pilori infection. Med Hypotheses 2004;62:378- 381.
Galloway PH, Warner SJ, Morshed MG, Mikelberg FS. Helico- bacter pylori infection and the risk for open-angle glaucoma. Ophthalmology 2003;110:922-925.
Kurtz S, Regenbogen M, Goldiner I, et al. No association be- tween Helicobacter pylori infection or CagA-bearing strains and glaucoma. J Glaucoma 2008;17:223-226.
Zullo A, Ridola L, Hassan C, et al. Glaucoma and Helicobacter pylori: eyes wide shut? Dig Liver Dis 2012;44:627-628.

There are 17 citations in total.

Details

Primary Language	Turkish
Journal Section	Research Articles
Authors	Baran Gencer This is me Fahri Güneş This is me Yusuf Ziya Tan This is me Erdem Akbal This is me Hasan Ali Tufan This is me Yeliz Ekim This is me Hacer Şen This is me Arzu Taşkıran Çömez This is me Semra Özdemir This is me Selçuk Kara This is me
Publication Date	March 1, 2014
Submission Date	March 2, 2015
Published in Issue	Year 2014 Volume: 41 Issue: 1

Cite

APA	Gencer, B., Güneş, F., Tan, Y. Z., Akbal, E., et al. (2014). Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori. Dicle Tıp Dergisi, 41(1), 82-85. https://doi.org/10.5798/diclemedj.0921.2014.01.0377
AMA	Gencer B, Güneş F, Tan YZ, Akbal E, Tufan HA, Ekim Y, Şen H, Çömez AT, Özdemir S, Kara S. Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori. diclemedj. March 2014;41(1):82-85. doi:10.5798/diclemedj.0921.2014.01.0377
Chicago	Gencer, Baran, Fahri Güneş, Yusuf Ziya Tan, Erdem Akbal, Hasan Ali Tufan, Yeliz Ekim, Hacer Şen, Arzu Taşkıran Çömez, Semra Özdemir, and Selçuk Kara. “Evaluation of Intraocular Pressure and Retinal Nerve Fiber Layer Thickness in Patients With Helicobacter Pylori”. Dicle Tıp Dergisi 41, no. 1 (March 2014): 82-85. https://doi.org/10.5798/diclemedj.0921.2014.01.0377.
EndNote	Gencer B, Güneş F, Tan YZ, Akbal E, Tufan HA, Ekim Y, Şen H, Çömez AT, Özdemir S, Kara S (March 1, 2014) Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori. Dicle Tıp Dergisi 41 1 82–85.
IEEE	B. Gencer, “Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori”, diclemedj, vol. 41, no. 1, pp. 82–85, 2014, doi: 10.5798/diclemedj.0921.2014.01.0377.
ISNAD	Gencer, Baran et al. “Evaluation of Intraocular Pressure and Retinal Nerve Fiber Layer Thickness in Patients With Helicobacter Pylori”. Dicle Tıp Dergisi 41/1 (March 2014), 82-85. https://doi.org/10.5798/diclemedj.0921.2014.01.0377.
JAMA	Gencer B, Güneş F, Tan YZ, Akbal E, Tufan HA, Ekim Y, Şen H, Çömez AT, Özdemir S, Kara S. Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori. diclemedj. 2014;41:82–85.
MLA	Gencer, Baran et al. “Evaluation of Intraocular Pressure and Retinal Nerve Fiber Layer Thickness in Patients With Helicobacter Pylori”. Dicle Tıp Dergisi, vol. 41, no. 1, 2014, pp. 82-85, doi:10.5798/diclemedj.0921.2014.01.0377.
Vancouver	Gencer B, Güneş F, Tan YZ, Akbal E, Tufan HA, Ekim Y, Şen H, Çömez AT, Özdemir S, Kara S. Evaluation of intraocular pressure and retinal nerve fiber layer thickness in patients with Helicobacter pylori. diclemedj. 2014;41(1):82-5.