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Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris

Year 2014, Volume: 41 Issue: 1, 144 - 150, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0389

Abstract

Objective: Psoriasis is a chronic, T-cell mediated inflammatory skin disease with multifactorial etiology. Adiponectin, leptin and apelin are the adipokines that aresecreted from adipose tissue and plays a role in T-cell immunity.In this study, it wasaimed to investigate potential relationship between adiponectin, leptin, apelin and psoriasis. Methods: Fasting plasma glucose, triglyceride, HDL cholesterol and serum adiponectin, leptin and apelin levels were measured in 50 adult patient with psoriasis, 20 patients with pemphigus vulgaris and 46 healthy individuals. In addition, BMI, waist circumference and blood pressure were measured in patient and control groups. Results: Metabolic syndrome frequency was found as significantly higher in patients with psoriasis than control group (p0.05, p>0.05 and p>0.05, respectively). No significant difference was found between PASI score and adiponectin, leptin, apelin values. Conclusion: In our study demonstrates the frequency of metabolic syndrome in patients with psoriasis. We think that adiponectin, leptin and apelin may play role in the pathogenesis of psoriasis, but these adipokines aren\'t markers, which are related to severity of disease.

References

  • Späh F. Inflammation in atherosclerosis and psoriasis com- mon pathogenic mechanisms and the potential for an inte- grated treatment approach. Br J Dermatol 2008;159:10-17.
  • Gülekon A, Adışen E. Psoriasis ve komorbiditeler. Türk derm 2008;42:23-25.
  • Vazquez-Vela MEF, Torres N, TovarAR. White adipose tis- sue as endocrine organ and its role in Obesity. Arch Med Res 2008; 9:715-728.
  • Schulze PC, Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clin Chim Acta 2005;362:1-11.
  • Boucher J, Masri B, Daviaud D. Apelin, a newly identified adipokine upregulated by insulin and obesity. Endocrinol- ogy 2005;146:1764-1771.
  • Hulthe J, Hulten LM, Fagerberg B. Low adipocyte-derived plasma protein adiponectin concentrations is associated with metabolic syndrome and small dense low-density li- poprotein particles: atherosclerosis and insulin resistance study. Metabolism 2003;52:1612-1614.
  • Maeda M, Shimomura I, Kishida K, et al. Diet-induced in- sulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002;8:731–717.
  • Ergün A. Obezite, besin alımı ve vücut ağırlığının kon- trolünde leptin. T Klin J Med Sci 1998;18:220-225.
  • Cohen AD, Gilutz H, Henkin Y, et al. Psoriasis and the meta- bolic syndrome. Acta Derm Venereol 2007;87:506-509.
  • Sommer DM, Jenisch S, Suchan M, et al. Increased preva- lence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 2006;298:321-328.
  • Campfield LA, Smith FJ, Guisez Y, et al. Recombi- nant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-549.
  • Gönül T, Başak PY, Kara Y, et al. Psoriasisli hastalarda se- rum leptin düzeylerinin araştırılması. Turkderm Deri Has- taliklari ve Frengi Arsivi 2009;43:48-52.
  • Wang Y, Chen J, Zhao Y, et al. Psoriasis is associated with increased levels of serum leptin. Br J Dermatol 2008;158:1134–1135.
  • Nakajima H, Nakajima K, Nagano Y, et al. Circulating level of chemerin is up regulated in psoriasis. J Dermatol Sci 2010;60:45-47.
  • Chen YJ, Wu CY, Shen JL, et al. Psoriasisin dependently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol 2008;144:1571-1575.
  • Gisondi P, Targher G, Zoppini G, et al. Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 2009;51:758-764.
  • Kaur S, Zilmer K, Leping V, et al. The levels of adiponectin and leptin and their relation to other markers of cardiovas- cular risk in patients with psoriasis. J Eur Acad Dermatol Venereol 2011;23:1468-3083.
  • Coimbra S, Oliveira H, Reis F, et al. Circulating adipokine levels in Portuguese patients with psoriasis vulgaris accord- ing to body mass index, severity and therapy. J Dermatol Sci 2009;55:202-204.
  • Takahashi H, Tsuji H, Takahashi I, et al. Prevalence of obesity/adiposity in Japanese psoriasis patients: adiposity is correlated with the severity of psoriasis. J Dermatol Sci 2009;55:74-76.
  • Çerman AA, Bozkurt S, Sav A, et al. Serum leptin levels, skin leptin and leptin receptor expression in psoriasis. Br J Dermatol 2008;159:820-826.
  • Jhonston A, Arnadottir S, Gudjonsson JE, et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous in- flammation. Br J Dermatol 2008;159:342-350.
  • Ercin CN, Dogru T, Tapan S, et al. Plasma apelin levels in subjects with nonalcoholic fatty liver disease. Metabolism 2010;59:977-981.
  • Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg 2009;19:1574-1580.
  • Castan-Laurell I, Vítkova M, Daviaud D, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Mol Cell Endocrinol 2005;245:7-9.

Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris

Year 2014, Volume: 41 Issue: 1, 144 - 150, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0389

Abstract

Amaç: Psoriasis multi faktöriyel etyolojili, kronik, T hücre aracılı inflamatuvar bir deri hastalığıdır. Adiponektin, leptin ve apelin adipoz dokulardan sekrete edilen ve T hücre immunitesi üzerinde rol oynayan adipokinlerdir. Bu çalışmadaadiponektin, leptin ve apelin düzeylerinin psoriasis vulgaris hastaları ile arasında olası ilişkinin araştırılması amaçlanmıştır. Yöntemler: Elli erişkin psoriasisli hasta ile kontrol grubu olarak alınan 20 pemfigus vulgarisli hasta ve 46 sağlıklı kişide açlık kan şekeri, trigliserid, HDL kolesterol, serum adiponektin, leptin ve apelin düzeyleri ölçüldü. Ayrıca hasta ve kontrol gruplarının vücut kitle indeksleri, bel çevresi, kan basıncı ölçümleri yapıldı. Bulgular: Psoriasisli hastalarda kontrol grubuna göre metabolik sendrom sıklığı anlamlı olarak yüksek bulundu (p0.05, p>0.05, p>0.05). Hastaların PASİ skoruile adiponektin, leptin ve apelin değerleri arasında istatiksel açıdan anlamlı bir fark bulunamadı (p>0.05). Sonuç: Sonuç olarak, çalışmamız psoriasis hastalarında metabolik sendrom sıklığını göstermektedir. Psoriasis patogenezinde adiponektin, leptin ve apelinin etkili olabileceğini fakat bu adipokinlerin hastalığın şiddetiyle ilgili belirteçler olmadığını düşünmekteyiz.

References

  • Späh F. Inflammation in atherosclerosis and psoriasis com- mon pathogenic mechanisms and the potential for an inte- grated treatment approach. Br J Dermatol 2008;159:10-17.
  • Gülekon A, Adışen E. Psoriasis ve komorbiditeler. Türk derm 2008;42:23-25.
  • Vazquez-Vela MEF, Torres N, TovarAR. White adipose tis- sue as endocrine organ and its role in Obesity. Arch Med Res 2008; 9:715-728.
  • Schulze PC, Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clin Chim Acta 2005;362:1-11.
  • Boucher J, Masri B, Daviaud D. Apelin, a newly identified adipokine upregulated by insulin and obesity. Endocrinol- ogy 2005;146:1764-1771.
  • Hulthe J, Hulten LM, Fagerberg B. Low adipocyte-derived plasma protein adiponectin concentrations is associated with metabolic syndrome and small dense low-density li- poprotein particles: atherosclerosis and insulin resistance study. Metabolism 2003;52:1612-1614.
  • Maeda M, Shimomura I, Kishida K, et al. Diet-induced in- sulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002;8:731–717.
  • Ergün A. Obezite, besin alımı ve vücut ağırlığının kon- trolünde leptin. T Klin J Med Sci 1998;18:220-225.
  • Cohen AD, Gilutz H, Henkin Y, et al. Psoriasis and the meta- bolic syndrome. Acta Derm Venereol 2007;87:506-509.
  • Sommer DM, Jenisch S, Suchan M, et al. Increased preva- lence of the metabolic syndrome in patients with moderate to severe psoriasis. Arch Dermatol Res 2006;298:321-328.
  • Campfield LA, Smith FJ, Guisez Y, et al. Recombi- nant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995;269:546-549.
  • Gönül T, Başak PY, Kara Y, et al. Psoriasisli hastalarda se- rum leptin düzeylerinin araştırılması. Turkderm Deri Has- taliklari ve Frengi Arsivi 2009;43:48-52.
  • Wang Y, Chen J, Zhao Y, et al. Psoriasis is associated with increased levels of serum leptin. Br J Dermatol 2008;158:1134–1135.
  • Nakajima H, Nakajima K, Nagano Y, et al. Circulating level of chemerin is up regulated in psoriasis. J Dermatol Sci 2010;60:45-47.
  • Chen YJ, Wu CY, Shen JL, et al. Psoriasisin dependently associated with hyperleptinemia contributing to metabolic syndrome. Arch Dermatol 2008;144:1571-1575.
  • Gisondi P, Targher G, Zoppini G, et al. Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol 2009;51:758-764.
  • Kaur S, Zilmer K, Leping V, et al. The levels of adiponectin and leptin and their relation to other markers of cardiovas- cular risk in patients with psoriasis. J Eur Acad Dermatol Venereol 2011;23:1468-3083.
  • Coimbra S, Oliveira H, Reis F, et al. Circulating adipokine levels in Portuguese patients with psoriasis vulgaris accord- ing to body mass index, severity and therapy. J Dermatol Sci 2009;55:202-204.
  • Takahashi H, Tsuji H, Takahashi I, et al. Prevalence of obesity/adiposity in Japanese psoriasis patients: adiposity is correlated with the severity of psoriasis. J Dermatol Sci 2009;55:74-76.
  • Çerman AA, Bozkurt S, Sav A, et al. Serum leptin levels, skin leptin and leptin receptor expression in psoriasis. Br J Dermatol 2008;159:820-826.
  • Jhonston A, Arnadottir S, Gudjonsson JE, et al. Obesity in psoriasis: leptin and resistin as mediators of cutaneous in- flammation. Br J Dermatol 2008;159:342-350.
  • Ercin CN, Dogru T, Tapan S, et al. Plasma apelin levels in subjects with nonalcoholic fatty liver disease. Metabolism 2010;59:977-981.
  • Soriguer F, Garrido-Sanchez L, Garcia-Serrano S, et al. Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus. Obes Surg 2009;19:1574-1580.
  • Castan-Laurell I, Vítkova M, Daviaud D, et al. Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ. Mol Cell Endocrinol 2005;245:7-9.
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Emine Tuğba Alataş This is me

İbrahim Kökçam This is me

Publication Date March 1, 2014
Submission Date March 2, 2015
Published in Issue Year 2014 Volume: 41 Issue: 1

Cite

APA Alataş, E. T., & Kökçam, İ. (2014). Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris. Dicle Tıp Dergisi, 41(1), 144-150. https://doi.org/10.5798/diclemedj.0921.2014.01.0389
AMA Alataş ET, Kökçam İ. Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris. diclemedj. March 2014;41(1):144-150. doi:10.5798/diclemedj.0921.2014.01.0389
Chicago Alataş, Emine Tuğba, and İbrahim Kökçam. “Investigation of Adiponectin, Leptin and Apelin Levels in Patients With Psoriasis Vulgaris”. Dicle Tıp Dergisi 41, no. 1 (March 2014): 144-50. https://doi.org/10.5798/diclemedj.0921.2014.01.0389.
EndNote Alataş ET, Kökçam İ (March 1, 2014) Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris. Dicle Tıp Dergisi 41 1 144–150.
IEEE E. T. Alataş and İ. Kökçam, “Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris”, diclemedj, vol. 41, no. 1, pp. 144–150, 2014, doi: 10.5798/diclemedj.0921.2014.01.0389.
ISNAD Alataş, Emine Tuğba - Kökçam, İbrahim. “Investigation of Adiponectin, Leptin and Apelin Levels in Patients With Psoriasis Vulgaris”. Dicle Tıp Dergisi 41/1 (March 2014), 144-150. https://doi.org/10.5798/diclemedj.0921.2014.01.0389.
JAMA Alataş ET, Kökçam İ. Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris. diclemedj. 2014;41:144–150.
MLA Alataş, Emine Tuğba and İbrahim Kökçam. “Investigation of Adiponectin, Leptin and Apelin Levels in Patients With Psoriasis Vulgaris”. Dicle Tıp Dergisi, vol. 41, no. 1, 2014, pp. 144-50, doi:10.5798/diclemedj.0921.2014.01.0389.
Vancouver Alataş ET, Kökçam İ. Investigation of adiponectin, leptin and apelin levels in patients with psoriasis vulgaris. diclemedj. 2014;41(1):144-50.