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Mean trombosit volume as a diagnostic indicator in hydatid disease

Year 2014, Volume: 41 Issue: 1, 163 - 165, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0392

Abstract

Objective: Since unilocular hydatid is an infectious disease, it progresses with inflammation. In our study we aimed to search if mean trombosit volume (MPV) which its results were known for inflammatory, the number of trombosit and the number of leukocyte can be used as a diagnose method in unilocular hydatid disease. Methods: In this study, we took out the data of MPV values, the number of leukocyte and Trombosit values of the patients diagnosed as unilocular hydatid disease from archival records between the years 2008 and 2013. Then we formed a control group of the same age and the same gender from people having disease. Results: In our study there were totally 97 patients, 52 patients in patient group and 45 patients in control group. The mean MPV values of patient group was 6.268 ± 0.819 fL, whereas it was 7.370 ± 1.102 fL in the control group. The mean leukocyte number was found as 10007 ± 3542 /mm3 in patient group and 8419 ± 2927 /mm3 in the control group. The mean number of platelets was 353470 ± 124900 /mm3 in the patient group, while it was 307880 ± 89281 /mm3 in the control group. Conclusion: The significance of decrease in MPV values shows the usability of MPV in diagnosis. As a response to infective diseases and inflammatory conditions, the changes in volumes of platelets can be used as diagnostic factor in antimicrobial and immune answers.

References

  • Kireşi DA, Karabacakoğlu A, Odev K, et al. Uncommon lo- cations of hydatid cysts. Acta Radiol 2003;44:622-636.
  • Hakverdi S, Sayar H, Yaldız M, ve ark. Çukurova yöresinde seyrek yerleşimli ekinokokkozis. Türk Parazitol Derg 2009;33:77-81.
  • Tagliasacchi D, Carboni G. Let’s observe the blood cells. Platelets 1997;12:134-137.
  • Andrews RK, Berndt MC. Platelet physiology and thrombo- sis. Thromb Res 2004;114:447-453.
  • Klinger MH. Platelets and inflammation. Anat Embryol (Berl) 1997;196:1-11.
  • Elzey BD, Tian J, Jensen RJ, et al. Platelet-mediated modula- tion of adaptive immunity: A communication link between innate and adaptive immune compartments. Immunity 2003;19:9–19.
  • Hunelshausen PV, Weber C. Platelets as immune cells. Bridging inflammation and cardiovascular disease. The review is part of a thematic series on Mechanisms, Mod- els, and In vivo imaging of thrombus formation. Circ Res. 2007;100:27-40.
  • Flad, HD, Brandt E. Platelet-derived chemokines: Patho- physiology and therapeutic aspects. Cell Mol Life Sci 2010;67:2363-2386.
  • Foote S. Blood platelets can kill malaria parasites. Res News Insc Org 2009;14:45.
  • Joseph M, Auriault C, Capron A, et al. A new function for platelets: IgE-dependent killing of schistosomes. Nature 1983;303:810-812.
  • Klinger MH. Platelets and inflammation. Anat Embryol (Berl) 1997;196:1-11.
  • Bout D, Joseph M, Pontet M, et al. Rat resistance to schis- tosomiasis: platelet-mediated cytotoxicity induced by C- reactive protein. Science 1986; 231:153-155.
  • Polack B, Peyron F , Auriault C. Platelet cytotoxicity against parasites. Nouv Rev Fr Hematol 1991;33:317-322.
  • Kadir S, Yalçın Ö, Balcik Ö Ş. İnflamasyonda Plateletlerin Rolü. Dicle Med J 2012;39:455-457
  • King SM, Reed GL. Development of platelet secretory granules. Semin Cell Dev Biol 2002;13:293-302.
  • Wiwanitkit V, Soogarun S, Saksirisampant W, et al.Platelet parameters in subjects infected with hookworm. Platelets 2003;14:391-393.

Mean trombosit volume as a diagnostic indicator in hydatid disease

Year 2014, Volume: 41 Issue: 1, 163 - 165, 01.03.2014
https://doi.org/10.5798/diclemedj.0921.2014.01.0392

Abstract

Amaç: Hidatik kist enfeksiyöz bir hastalık olması nedeniyle hastalık inflamasyonla seyreder. Biz bu çalışmada inflamatuar yanıta sonuçları bilinen Ortalama Trombosit Hacmi (MPV), trombosit sayısı ve lökosit sayılarının hidatik kist hastalığında tanı yöntemi olarak kullanılıp kullanılamayacağını araştırmayı amaçladık. Yöntemler: Bu çalışmada 2008-2013 yılları arasında hidatik kist tanısı almış hastaların MPV değerlerini, lökosit sayıları ve trombosit değerlerini arşiv kayıtlarından çıkardık. Yaklaşık olarak aynı yaş ve aynı cinsiyete sahip eşit sayıda inflamatuar hastalığı olmayan kişilerden kontrol grubu oluşturulduk. Bulgular: Çalışmamızda 52 hasta grubunda, 45 kontrol grubunda olmak üzere toplam 97 hasta bulunmaktadır. MPV değerleri hasta grubunda ortalama 6,268 ± 0,819 fL olarak bulunurken, kontrol grubunda ortalama 7,370 ± 1,102 fL olarak bulundu (p>0,05). Lökosit değerleri hasta grubunda ortalama 10007 ± 3542/mm3 olarak bulunurken, kontrol ortalama 8419 ± 2927 /mm3 olarak bulundu. Trombosit sayıları hasta grubunda ortalama 353470 ± 124900/mm3 olarak bulunurken, kontrol grubunda ortalama 307880 ± 89281 /mm3 olarak bulundu. Sonuç: MPV değerindeki düşüşün anlamlı olması, MPV\'nin tanıda kullanılabilirliğini göstermektedir. Enfektif hastalıklar ve inflamatuar durumlara cevapta antimikrobiyal ve immün cevapta yapısal değişikler gösteren trombositlerin volümlerindeki değişimleri diagnostik bir faktör olarak kullanılabilir.

References

  • Kireşi DA, Karabacakoğlu A, Odev K, et al. Uncommon lo- cations of hydatid cysts. Acta Radiol 2003;44:622-636.
  • Hakverdi S, Sayar H, Yaldız M, ve ark. Çukurova yöresinde seyrek yerleşimli ekinokokkozis. Türk Parazitol Derg 2009;33:77-81.
  • Tagliasacchi D, Carboni G. Let’s observe the blood cells. Platelets 1997;12:134-137.
  • Andrews RK, Berndt MC. Platelet physiology and thrombo- sis. Thromb Res 2004;114:447-453.
  • Klinger MH. Platelets and inflammation. Anat Embryol (Berl) 1997;196:1-11.
  • Elzey BD, Tian J, Jensen RJ, et al. Platelet-mediated modula- tion of adaptive immunity: A communication link between innate and adaptive immune compartments. Immunity 2003;19:9–19.
  • Hunelshausen PV, Weber C. Platelets as immune cells. Bridging inflammation and cardiovascular disease. The review is part of a thematic series on Mechanisms, Mod- els, and In vivo imaging of thrombus formation. Circ Res. 2007;100:27-40.
  • Flad, HD, Brandt E. Platelet-derived chemokines: Patho- physiology and therapeutic aspects. Cell Mol Life Sci 2010;67:2363-2386.
  • Foote S. Blood platelets can kill malaria parasites. Res News Insc Org 2009;14:45.
  • Joseph M, Auriault C, Capron A, et al. A new function for platelets: IgE-dependent killing of schistosomes. Nature 1983;303:810-812.
  • Klinger MH. Platelets and inflammation. Anat Embryol (Berl) 1997;196:1-11.
  • Bout D, Joseph M, Pontet M, et al. Rat resistance to schis- tosomiasis: platelet-mediated cytotoxicity induced by C- reactive protein. Science 1986; 231:153-155.
  • Polack B, Peyron F , Auriault C. Platelet cytotoxicity against parasites. Nouv Rev Fr Hematol 1991;33:317-322.
  • Kadir S, Yalçın Ö, Balcik Ö Ş. İnflamasyonda Plateletlerin Rolü. Dicle Med J 2012;39:455-457
  • King SM, Reed GL. Development of platelet secretory granules. Semin Cell Dev Biol 2002;13:293-302.
  • Wiwanitkit V, Soogarun S, Saksirisampant W, et al.Platelet parameters in subjects infected with hookworm. Platelets 2003;14:391-393.
There are 16 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Şamil Günay This is me

İrfan Eser This is me

Zafer Hasan Ali Sak This is me

İbrahim Can Kürkçüoğlu This is me

Publication Date March 1, 2014
Submission Date March 2, 2015
Published in Issue Year 2014 Volume: 41 Issue: 1

Cite

APA Günay, Ş., Eser, İ., Sak, Z. H. A., Kürkçüoğlu, İ. C. (2014). Mean trombosit volume as a diagnostic indicator in hydatid disease. Dicle Medical Journal, 41(1), 163-165. https://doi.org/10.5798/diclemedj.0921.2014.01.0392
AMA Günay Ş, Eser İ, Sak ZHA, Kürkçüoğlu İC. Mean trombosit volume as a diagnostic indicator in hydatid disease. diclemedj. March 2014;41(1):163-165. doi:10.5798/diclemedj.0921.2014.01.0392
Chicago Günay, Şamil, İrfan Eser, Zafer Hasan Ali Sak, and İbrahim Can Kürkçüoğlu. “Mean Trombosit Volume As a Diagnostic Indicator in Hydatid Disease”. Dicle Medical Journal 41, no. 1 (March 2014): 163-65. https://doi.org/10.5798/diclemedj.0921.2014.01.0392.
EndNote Günay Ş, Eser İ, Sak ZHA, Kürkçüoğlu İC (March 1, 2014) Mean trombosit volume as a diagnostic indicator in hydatid disease. Dicle Medical Journal 41 1 163–165.
IEEE Ş. Günay, İ. Eser, Z. H. A. Sak, and İ. C. Kürkçüoğlu, “Mean trombosit volume as a diagnostic indicator in hydatid disease”, diclemedj, vol. 41, no. 1, pp. 163–165, 2014, doi: 10.5798/diclemedj.0921.2014.01.0392.
ISNAD Günay, Şamil et al. “Mean Trombosit Volume As a Diagnostic Indicator in Hydatid Disease”. Dicle Medical Journal 41/1 (March 2014), 163-165. https://doi.org/10.5798/diclemedj.0921.2014.01.0392.
JAMA Günay Ş, Eser İ, Sak ZHA, Kürkçüoğlu İC. Mean trombosit volume as a diagnostic indicator in hydatid disease. diclemedj. 2014;41:163–165.
MLA Günay, Şamil et al. “Mean Trombosit Volume As a Diagnostic Indicator in Hydatid Disease”. Dicle Medical Journal, vol. 41, no. 1, 2014, pp. 163-5, doi:10.5798/diclemedj.0921.2014.01.0392.
Vancouver Günay Ş, Eser İ, Sak ZHA, Kürkçüoğlu İC. Mean trombosit volume as a diagnostic indicator in hydatid disease. diclemedj. 2014;41(1):163-5.