Serum adipocytokine levels in patients with colorectal cancer

Year 2010, Volume: 37 Issue: 4, 321 - 325, 01.12.2010

Serdar Erkasap Eda Özçelik Sema Uslu Mehmet Kara Nilüfer Erkasap

Abstract

Objectives: Adipose tissue, besides its main function as an energy storage depot, is currently considered an en­docrine organ that secretes several self-produced cytok­ines. Leptin and resistin play an important role in energy homeostasis, glucose, lipid metabolism and regulation of body weight. The aim of the current study was to deter­mine the concentration of leptin and resistin in pre-opera­tional and post-operational periods of patients diagnosed as colorectal cancer. Materials and methods: The body mass index (BMI) and values of leptin and resistin in blood at diagnosis were measured in 12 colorectal cancer patients in pre- and post-operational periods and in 12 age- and sex-matched controls. Serum leptin and resistin concentrations were measured by ELISA method. Results: Decreased leptin (1.95±0.62 ng/ml) and resis­tin (4.32±1.83 ng/ml) levels were found in pre-operational group compared with the control group (leptin: 6.12±0.82 ng/ml; resistin: 10.75±1.46 ng/ml) (p

Keywords

Colorectal neoplasm, leptin, resistin serum

Kolerektal kanserli hastalarda serum adipositokin düzeyleri

Abstract

Amaç: Yağ dokusu, bir enerji deposu olan ana işlevinin yanında, bazı sitokinler salgılayarak bir endokrin organ olarak kabul edilir. Leptin ve rezistin, enerji homeostazi­sinde, glikoz, lipid metabolizmasında ve vücut ağırlığının düzenlenmesinde önemli bir rol oynamaktadır. Bu çalış­manın amacı, kolorektal kanserli hastalarda operasyon öncesi ve operasyon sonrası dönemlerde leptin ve rezis­tin konsantrasyonlarının belirlenmesidir. Gereç ve yöntem: Toplam 12 kolorektal kanserli hastada ameliyet öncesi ve sonrası dönemde ve yaş ve cinsiyet uyumlu 12 kişiden oluşan kontrol grubunda vücut kitle in­deksi (VKİ) ve kan örneklerinde leptin ve rezistin düzeyleri ölçüldü. Serum leptin ve rezistin konsantrasyonları ELISA ile yöntemi ile ölçüldü. Bulgular: Operasyon öncesi grup (leptin: 1.95±0.62 ng/ml; resistin 4.32±1.83 ng/ml) kontrol grubuna (leptin: 6.12±0.82 ng/ml; resistin: 10.75±1.46 ng/ml) göre karşı­laştırıldığında leptin ve rezistin düzeylerinde azalma göz­lemlendi (sırasıyla, p

Keywords

Kolorektal kanser, leptin, rezistin, se­rum

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