Combination of surgical excision and interferon alpha-2a treatment in squamous cell papilloma with extensive oral involvement

Year 2010, Volume: 37 Issue: 3, 287 - 290, 01.09.2010

Ünal Sahin Tayyar Selçuk Ercan Demirbağ Birol Civelek Selim Çelebioğlu

Abstract

Oral squamous cell papilloma is a cutaneus lesions occurring due to human papilloma virus infections. These lesions spread locally and tend to have a high recurrence rate. Cases usually have a slow progression rather than acute symptoms. The course of disease is mostly subclinical. Although there are various treatment modalities which are recommended for the treatment of the disease, there is no particular and effective treatment modality that was proven. Limited surgical excisions result in frequent recurrences due to the presence of HPV in latent form around the lesions. Therefore, surgical excisions are combined with the other treatments such as systemically used interferons. We aimed to present a case of squmous cell papilloma with locally extensive lesions in the oral mucosa. Our patient was managed by the surgical excision and systemically given interferon treatment.

Keywords

Squmous cell papilloma, surgical excision, interferon alpha, treatment.

Yaygın oral tutulumlu skuamöz hücreli papillomun cerrahi eksizyon ve interferon alfa-2a ile kombine tedavisi

Abstract

Oral skuamöz hücreli papillom, Human papilloma virüs (HPV) infeksiyonlarına bağlı olarak gelisen kutanöz lezyonlardandır. Bu lezyonlar, lokal yayılım gösterirler ve yüksek tekrarlama oranına sahiptirler. Olgular, genellikle akut semptom vermek yerine yavas büyüyen ve uzun süren subklinik tablo ile seyretmektedirler. Hastalığın tedavisinde önerilen birçok tedavi yöntemi olmasına rağmen tek basına etkinliği kanıtlanmıs bir yöntem bulunmamaktadır. Sınırlı tutulmus cerrahi eksizyonlar, lezyon etrafındaki latent formdaki HPV\'lerin varlığı nedeniyle sıklıkla rekürrens ile sonuçlanmaktadır. Bu nedenle cerrahi eksizyonlar sistemik interferon kullanımı gibi diğer tedavi seçenekleri ile kombine edilmektedir. Çalısmamızda cerrahi eksizyon ve sistemik interferon alfa kombinasyonu ile tedavi edilmiş yaygın oral tutulumlu bir skuamöz hücreli papillom olgusunu sunmayı amaçladık.

Keywords

Skuamöz hücreli papillom, cerrahi eksizyon, interferon alfa, tedavi.

References

• Murphy GF. The skin. In: Kumar V, Cotran RS, Robbins SL, eds. Basic Pathology 6th edn. Philedelphia: W.B. Saunders Company, 1997: 697-712.
• Premoli-de-Percoco G, Galindo I, Ramirez JL, et al. Detec- tion of human papillomavirus-related oral verruca vulgaris among Venezuelans. J Oral Pathol Med 1993;22:113-6.
• Janet S, Donna IP, Patricia S, Douglas PS. Oral condylomata in children. Arch Pediatr Adolesc Med 1999;153:651-4.
• Henley JD, Summerlin DJ, Tomich CE. Condyloma acumi- natum and condyloma-like lesions of the oral cavity: a study of 11 cases with an intraductal component. Histopa- tology 2004;44:216-21.
• Garlick JA, Taichman LB. Human papillomavirus infection of the oral mucosa. Am J Dermatopathol 1991;13:386-95.
• Panici PB, Scambia G, Perrone L et al. Oral condyloma le- sions in patients with extensive genital human papillomavi- rus infection. Am J Obstet Gynocol 1992;167:451-8.
• Juraj P, William F, Stefan S et al. Human papilloma virus infection in the oral cavity-a source of infection. J Eur Acad Dermatol Venereol 1998;10:275-7.
• Stina S. Human papillomavirus infections and oral tumors. Med Microbiol Immunol 2003;192:123-8.
• Adler-Storthz K, Newland JR, Tessin BA, et al. Identifi cation of human papillomavirus types in oral verruca vulgaris. J Oral Pathol 1986;15:230-3.
• Hertz RS. The occurence of a verruca vulgaris on an intraoral skin graft. Oral Surg Oral Med Oral Pathol 1972;34.934-42.
• Ashiru JO, Ogunbanjo BO, Rotowa NA, Adeyemi-Dora FAB. Intraoral condyloma accuminata: a case report. Br J Vener Dis 1983;59:325-6.
• Tsamboas D, Georgiou S, Monastirli A, Sakkis TH, Sagrio- tis A, Goerz G. Treatment of condylomata accuminata with oral isotretinoin. J Urol 1997;158:1810-2.
• Franco I. Oral cimetidine for the management of genital and perigenital wards in children. J Urol 2000;164:1074-5.
• Cardamakis EK, Kotoulas GB, Dimopoulos DP, et al. Comparative study of systemic interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment recurrent condyloma accuminata. Arch Gynecol Obstet 1996;258:35-41.
• Aynur A, Rana A, Yücel A, et al. Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b. Int J Dermatol 2003;42:733-5.