Corrected Qt interval in patients with metabolic syndrome

Year 2011, Volume: 38 Issue: 3, 274 - 277, 01.09.2011

Fatma Paksoy Turgay Ulaş Cemal Bes Mehmet Sinan Dal Fatih Borlu

https://doi.org/10.5798/diclemedj.0921.2011.03.0030

Abstract

Objectives: Metabolic syndrome may be associated with increased cardiovascular mortality and morbidity. However, prolongation of QT intervals due to metabolic syndrome is still unclear. The purpose of this study was to investigate the incidence prolonged QT intervals in pa­tients with metabolic syndrome and also demonstrate the relationship between them. Therefore, we aimed to inves­tigate the relationship between metabolic syndrome and the QT prolongation in a large patient group. Materials and methods: A total of 1009 individuals were enrolled in this study. Metabolic syndrome was defined according to the IDF criteria and the QTc intervals were measured by using Bazett Formula. QT ≤ 0.44 second was accepted as normal. Results: Totally, 278 male and 731 female individuals of 1009 cases were enrolled in this study. The average dura­tion of corrected QT of men according to the Bazzett for­mula were found as 0,448±0,04 second and QT interval of women were 0,449±0,05 second. QT intervals of both women and men with metabolic syndrome were signifi­cantly higher than normal limits of QT interval (p

Keywords

Metabolic cardiovascular syndrome, arrhyth­mia, cardiovascular diseases, QT interval

Metabolik sendromlu hastalarda düzeltilmiş Qt süresi

Abstract

Amaç: Metabolik sendrom artmış kardiyovasküler morta&shy;lite ve morbidite ile ilişkili olabilir. Fakat metabolik send&shy;romun QT sürelerinin uzamasına neden olduğu halen belirsizdir. Bu çalışmanın amacı metabolik sendromla bir&shy;likte bulunan uzamış QT süresinin sıklığını araştırmak ve varsa aralarındaki ilişkiyi göstermektir. Bu amaçla geniş bir hasta grubunda metabolik sendromun QT uzaması ile ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Çalışmaya 1009 hasta dahil edildi. Metabolik sendrom IDF kriterlerine göre tanımlandı ve QT süresi Bazett formülü kullanılarak hesaplandı. QT&le;0,44 sn normal olarak kabul edildi. Bulgular: Çalışmaya alınan 1009 olgunun 278\'i erkek, 731\'i kadındı. Erkeklerin Bazett formülüne göre düzeltil&shy;miş ortalama QT sureleri 0,448&plusmn;0,040 sn, kadınların ise 0,449&plusmn;0 ,050 sn idi. Hem erkek hem de kadın hastalar&shy;da QTc suresi normale göre anlamlı yüksek bulundu (p< 0,01). Sonuç: Metabolik sendrom uzamış QT süresiyle ilişkili bulundu. Çalışmamızda elde ettiğimiz bulgular metabolik sendrom hastalarında QT süresinin artmış olduğunu des&shy;teklemektedir.

Keywords

Metabolik kardiyovasküler sendrom, aritmi, kalp ve damar hastalıkları, QT süresi

References

• Dekker JM, Schouten EG, Klootwijk P, Pool J, Kromhout D. Association between QT interval and coronary heart dis- ease in middle-aged and elderly men. The Zutphen Study. Circulation 1994;90(2): 779-85.
• Goldberg RJ, Bengtson J, Chen ZY, Anderson KM, Locati E, Levy D. Duration of the QT interval and total and car- diovascular mortality in healthy persons (The Framingham Heart Study experience). Am J Cardiol 1991;67(1): 55-8.
• Rautaharju PM, Manolio TA, Psaty BM, Borhani NO, Furb- erg CD. Correlates of QT prolongation in older adults (the Cardiovascular Health Study). Cardiovascular Health Study Collaborative Research Group. Am J Cardiol 1994;73(13): 999-1002.
• Nakanishi S, Yamada M, Hattori N, Suzuki G. Relation be- tween QT duration and mortality in an elderly Japanese population. Am J Cardiol 2004;93(9): 1182-5.
• Wong KY, McSwiggan S, Kennedy NS, et al. Spectrum of cardiac abnormalities associated with long QT in stroke survivors. Heart 2005;91(10): 1306-10.
• Rana BS, Lim PO, Naas AA, et al. QT interval abnormalities are often present at diagnosis in diabetes and are better pre- dictors of cardiac death than ankle brachial pressure index and autonomic function tests. Heart 2005;91(1): 44-50.
• SoRelle R. QTc interval and B-type natriuretic peptide levels predict death in patients with advanced heart failure. Circu- lation 2003;107(13): e9024-32.
• Yasar AS, Basar N, Kasapkara A, Yuksel IO, Ipek G, Bilge M. [Impact of metabolic syndrome on ST segment resolu- tion after thrombolytic therapy for acute myocardial infarc- tion ]. Dicle Tip Dergisi 2010;37(3): 276-81.
• Cowan JC, Yusoff K, Moore M, et al. Importance of lead selection in QT interval measurement. Am J Cardiol 1988;61(1): 83-7.
• Toivonen L. More light on QT interval measurement. Heart 2002;87(3): 193-4.
• National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Pro- gram (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106(25): 3143-421.
• Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Len- fant C; American Heart Association; National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/ American Heart Association conference on scientific issues related to definition. Circulation 2004;109(3): 433-8.
• Ford ES, Giles WH, Dietz WH. Prevalence of the meta- bolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287(3): 356-9.
• Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome--a new worldwide definition. Lancet 2005;366(9491): 1059-62.
• Schouten EG, Dekker JM, Meppelink P, Kok FJ, Vanden- broucke JP, Pool J. QT interval prolongation predicts car- diovascular mortality in an apparently healthy population. Circulation 1991;84(4): 1516-23.
• Moss AJ, Schwartz PJ, Crampton RS, et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation 1991;84(3): 1136-44.
• Bednar MM, Harrigan EP, Anziano RJ, Camm AJ, Ruskin JN. The QT interval. Prog Cardiovasc Dis 2001;43(5 Suppl 1): 1-45.
• Al-Khatib SM, LaPointe NM, Kramer JM, Califf RM. What clinicians should know about the QT interval. JAMA 2003;289(16): 2120-7.
• Moss AJ. Measurement of the QT interval and the risk as- sociated with QTc interval prolongation: a review. Am J Cardiol 1993;72(6): 23B-25B.
• Mİller M. QT interval in relation to ventricular arrhythmias and sudden cardiac death in postmyocardial infarction pa- tients. Acta Med Scand 1981;210(1-2): 73-7.
• Peters RW, Byington RP, Barker A, Yusuf S. Prognostic val- ue of prolonged ventricular repolarization following myo- cardial infarction: the BHAT experience. The BHAT Study Group. J Clin Epidemiol 1990;43(2): 167-72.
• Bellavere F, Ferri M, Guarini L, et al. Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death? Br Heart J 1988;59(3): 379-83.
• Festa A, D’Agostino R Jr, Rautaharju P, Mykkänen L, Haff- ner SM. Relation of systemic blood pressure, left ventricu- lar mass, insulin sensitivity, and coronary artery disease to QT interval duration in nondiabetic and type 2 diabetic sub- jects. Am J Cardiol 2000;86(10): 1117-22.
• Dekker JM, Schouten EG, Klootwijk P, Pool J, Kromhout D. Association between QT interval and coronary heart dis- ease in middle-aged and elderly men. The Zutphen Study. Circulation 1994;90(2): 779-85.
• Grandinetti A, Seifried S, Mor J, Chang HK, Theriault AG. Prevalence and risk factors for prolonged QTc in a multi- ethnic cohort in rural Hawaii. Clin Biochem 2005;38(2): 116-22.
• Soydinc S, Davutoglu V, Akcay M. Uncomplicated meta- bolic syndrome is associated with prolonged electrocardio- graphic QTc interval and QTc dispersion. Ann Noninvasive Electrocardiol 2006;11(4): 313-7.
• Li W, Bai Y, Sun K, et al. Patients with metabolic syndrome have prolonged corrected QT interval (QTc). Clin Cardiol 2009;32(12): E93-9
• Faramawi MF, Wildman RP, Gustat J, Rice J, Abdul Kar- eem MY. The association of the metabolic syndrome with QTc interval in NHANES III. Eur J Epidemiol 2008;23(7): 459-65.
• Grandinetti A, Chow DC, Miyasaki M, Low P. Association of increased QTc interval with the cardiometabolic syn- drome. J Clin Hypertens (Greenwich) 2010;12(4): 315-20.