Procalcitonin and other acute phase reactants in patients with chronic obstructive pulmonary disease exacerbation

Year 2011, Volume: 38 Issue: 2, 137 - 142, 01.06.2011

Cemil Civelek İlhan Korkmaz Şevki Hakan Eren Fatma Mutlu Kukul Güven Şule Karadayı Ömer Tamer Doğan Ziynet Çınar İnan Beydilli

https://doi.org/10.5798/diclemedj.0921.2011.02.0003

Abstract

Objectives: The aim of this study was to investigate the correlation between procalcitonin and other acute phase reactants, and also analyze their relationship with clini­cal situation in chronic obstructive pulmonary disease (COPD) acute exacerbations. Materials and methods: The study was made with 122 acute COPD exacerbated patients, who were admitted to emergency service. Patients with below 0.25 ng/ml PCT value included Group 1, and the patients with PCT val­ues ≥ 0.25 ng/ml Group 2. Serum procalcitonin levels, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) values and white blood cell (WBC) counts were measured. Also, patients hospitalization time and mortal­ity rates were recorded and compared with PCT. Results: Patients were divided in 3 groups according to their clinical diagnosis; Pneumonia (n=27), Mycoplasma-Chlamydia pneumonia (n=11) and the patients with only COPD exacerbation(n=84). Mean PCT values accord­ing to the groups were 9.47 ± 8.1 ng/ml, 0.41 ± 0.2 ng/ml, and 0.21 ± 0.05 ng/ml respectively. The relationship between PCT with CRP and white blood cell has been found between significiant (p=0.001, p=0.005 respec­tively), whereas the relationship between PCT and ESR was nonsignificant (p=0.55). Procalcitonin and CRP had a positive correlation with the hospitalization time (p=0.034, p=0.022 respectively). The mean ± standard error of PCT for the patients who died was 28.3 ± 27.5 ng/ml, and the difference between patients who died or were discharged was statistically significant (p= 0.012). Conclusion: PCT can be a useful indicator for morbidity and prognosis in COPD patients.

Keywords

Chronic obstructive pulmonary disease, pro­calcitonin, acute phase reactants, emergency service.

Kronik obstruktif akciğer hastalığı akut alevlenmeli hastalarda prokalsitonin ve diğer akut faz belirteçleri

Abstract

Amaç: Çalışmanın amacı kronik obstruktif akciğer hasta­lığı (KOAH) akut alevlenmeli hastaların serum prokalsito­nin (PCT) ölçümü ile diğer akut faz belirteçlerini karşılaş­tırmak ve klinikle ilişkisini araştırmaktır. Gereç ve yöntem: Çalışma acil servise başvuran 122 KOAH akut alevlenmeli hasta ile yapıldı. Prokalsitonin (PCT) değeri 0.05). Has­taların PCT ve CRP değerleri ile hastanede kalış sürele­ri arasında aynı yönlü ilişki saptandı (sırasıyla p=0.034, p=0.022). Eksitus olan hastalardaki PCT ortalama değeri 28.3 ± 27.5 ng/ml olup taburcu olanlara oranla anlamlı olarak yüksek bulundu (p= 0.012). Sonuç: Elde ettiğimiz verilere dayanarak PCT\'nin KOAH akut alevlenmeli hastalarda morbidite ve prognozunun belirlenmesinde yararlı bir gösterge olarak kullanılabile­ceği sonucuna varıldı.

Keywords

Kronik obstruktif akciğer hastalığı, prokalsitonin, akut faz belirteçleri, acil servis.

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