Comparison of the sedative effects of midazolam and dexmedetomidine during regional anaesthesia

Year 2011, Volume: 38 Issue: 2, 148 - 154, 01.06.2011

Mehmet Korkmaz Alp Gurbet Şükran Şahin Özden Özkurt Pürcü

https://doi.org/10.5798/diclemedj.0921.2011.02.0005

Cited By: 1

Abstract

Objective: The aim of this study was to compare the effi­cacy of dexmedetomidine versus midazolam for sedation under spinal anesthesia for arthroscopic knee surgery. Materials and methods: Fifty adult patients, 18 to 65 years, were randomized into two groups: Group M re­ceived 0.04 mg/kg iv bolus midazolam followed by admin­istration of 0.5 mg boluses to provide Ramsay sedation Scale (RSS) 3-4. Group D received dexmedetomidine loading dose of 1 μg/kg/h over 10 minutes and the main­tenance dose of 0.2-0.7 μg/kg/h to achieve an adequate level of RSS 3-4. Recovery was evaluated with Modified Aldrete Scale. Pain was scored using Verbal rating scale (VRS). Postoperative VRS and Quality of Recovery (QoR) were recorded. Patients were asked to fill the question­naire that included 4 questions, and patient satisfaction was rated with VRS. Results: Heart rate and mean blood pressure values were found to be decreased in group D when compared with Group M (p

Keywords

Regional anesthesia, midazolam, dexme­detomidine, sedation.

Rejyonel anestezi sırasında midazolam ve deksmedetomidin\'in sedatif etkilerinin karşılaştırılması

Abstract

Amaç: Bu çalışmada, spinal anestezi altında artroskopik diz cerrahisi uygulanacak olgulara sedasyon amacıyla deksmedetomidin ve midazolam uygulamasının etkilerini karsılaştırmayı amaçladık. Gereç ve yöntem: Yaşları 18-65 yıl arasında değişen 50 olgu randomizasyon ile iki gruba ayrıldı: Grup M\'deki ol­gulara midazolam 0.04 mg/kg intravenöz (iv) uygulandık­tan sonra Ramsay sedasyon skoru (RSS) 3-4 olacak şe­kilde 0,5 mg ek dozlarla işleme devam edildi. Grup D\'deki olgulara deksmedetomidin 1 μg kg/sa olacak şekilde 10 dakika yükleme dozu uygulandı. Takiben olguların RSS 3-4 olacak şekilde 0,2-0,7 μg/kg/sa deksmedetomidin in­füzyonuna başlandı. Operasyon süresince olguların vital bulguları kaydedildi. Olguların derlenmeleri modifiye Ald­rete skoru (MAS) ile belirlendi. Ağrı değerlendirmesinde sözel nümerik skala (VRS) kullanıldı. Postoperatif VRS ve derlenme kalite skorları (QoR) kaydedildi. Olgulardan 4 sorudan oluşan geri bildirim anketini doldurmaları istendi. Olgu memnuniyeti VRS ile değerlendirildi. Bulgular: Grup D\'de kalp hızları Grup M\'ye göre düşük bulundu (p

Keywords

Rejyonal anestezi, midazolam, deks­medetomidin, sedasyon.

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