BibTex RIS Cite

Comparison of supportive treatment and pleurodesis in patients with malignant pleural mesothelioma

Year 2012, Volume: 39 Issue: 4, 509 - 512, 01.12.2012
https://doi.org/10.5798/diclemedj.0921.2012.04.0191

Abstract

Objectives: Malignant Pleural Mesothelioma (MPM) is a poor prognosis cancer that affects pleura. This study was designed for examination of the differences between MPM patients which who were received only supportive treatment and supportive treatment plus pleurodesis. Materials and methods: The files of 96 MPM patients were analyzed retrospectively who were followed up in Dicle University Medical Faculty Hospital. Age, gender, exposure of asbestos, diagnostic methods, histopathological types and treatment regimens were recorded. Results: The mean age of 96 MPM patients were 60.4 ± 12.6 years. The sixty-three (65.6%) patients were male and 33 (34.4%) were female. A total 75 (78.1%) patients have environmental asbestos exposure and mean environmental asbestos exposure time was 33 years. The epithelial type of pleural mesothelioma was determined in 63 patients. Pleural fluid cytology was positive in 30 patients. The most detected symptom was dyspnea which was determined in 91 cases. Thirty patients were taken only supportive treatment and 66 were taken supportive treatment plus pleurodesis. The median survival time was 10 months in the total of the two groups. Median survival was 10.7 months, in the group that treated with pleurodesis and 9.1 months in the group that not treated with pleurodesis. However, this difference was not statistically significant (p = 0.35). Conclusions: Malignant pleural mesothelioma is an aggressive form of cancer which is resistant to many therapeutic options. Progressive dyspnea is primary symptom in these patients and often depends on the pleural fluid. Pleurodesis is an option to control the fluid. However, there is not any contribution on survival, alone. Extensive investigations are needed on this topic.

References

  • Boutin C, Schlesser M, Frenay C, Astoul P. Malignant pleural mesothelioma. Eur Respir J 1998; 12(4): 972-81.
  • Sterman DH, Kaiser LR, Albelda SM. Advances in the treat- ment of malignant pleural mesothelioma. Chest 1999;116(2): 504-20.
  • Metintaş S, Metintaş M, Uçgun I, Onen U. Malignant me- sothelioma due to environmental exposure to asbestos. Follow up of a Turkish cohort living in a rural area. Chest 2002;122(6):2224-9.
  • Alberts AS, Falkson G, Goedhals L, Vorobiof DA, Van der Merwe CA. Malignant pleural mesothelioma: a disease unaf- fected by current therapeutic maneuvers. J Clin Oncol 1988; 6(3): 527–35.
  • Schouwink H, Korse CM, Bonfrer JM, Hart AA, Baas P. Prog- nostic value of the serum tumour markers Cyfra 21-1 and tissue polypeptide antigen in malignant mesothelioma. Lung Cancer 1999; 25(1): 25–32.
  • Law MR, Gregor A, Hodson ME, Bloom HJ, Turner-Warwick M. Malignant mesothelioma of the pleura: A study of 52 treated and 64 untreated patients. Thorax 1984; 39(4): 255-9.
  • Walker-Renard P, Vaughan LM, Shan SA. Chemical pleurode- sis for malignant pleural effusions. Ann Intern Med 1994;120(1):56-64.
  • Metintas M, Ak G, Erginel S, et al. A retrospective analysis of malignant pleural mesothelioma patients treated either with chemotherapy or best supportive care between 1990 and 2005 A single institution experience. Lung Cancer 2007;55(3):379- 87.
  • Yazicioglu S. Pleural calcification associated with exposure to chrysotile asbestos in southeast Turkey. Chest 1976;70(1):43- 7.
  • Carkanat AI, Abdurrahman A, Abakay O, Cengizhan S, Se- limoglu SH, Senyigit A. The incidence of mesothelioma has not decreased for the last twenty years in Southeast region of Anatolia. Afr Health Sci 2011;11(3): 346-52.
  • Senyiğit A, Babayiğit C, Gökirmak M, Topçu F, Asan E, Coşkunsel M. Incidence of malignant pleural mesothelioma due to environmental asbestos fiber exposure in the southeast of Turkey. Respiration 2000;67(6):610-14.
  • Senyiğit A, Bayram H, Babayiğit C, et al. Malignant pleural mesothelioma caused by environmental exposure to asbestos in the Southeast of Turkey: CT findings in 117 patients. Res- piration 2000;67(6):615-22.
  • Metintaş M, Özdemir N, Hillerdal G. Environmental asbestos exposure and malignant pleural mesothelioma. Respir Med 1999; 93(5): 349-55.
  • Tanrikulu AC, Senyigit A, Dagli CE, Babayigit C, Abakay A. Environmental malignant pleural mesothelioma in Southeast Turkey. Saudi Med J 2006;27(10):1605-7.
  • Zervos MD, Bizekis C, Pass HI. Malignant mesothelioma 2008. Curr Opin Pulm Med 2008; 14(4): 303-9.
  • Selçuk ZT, Cöplü L, Emri S. Malignant pleural mesothelioma due to environmental mineral fiber exposure in Turkey. Anal- ysis of 135 cases. Chest 1992;102(3):790-6.
  • Alberts AS, Falkson G, Goedhals L, Vorobiof DA, Van der Merwe CA. Malignant pleural mesothelioma: A disease unaf- fected by current therapeutic maneuvers. J Clin Oncol 1988; 6(3): 527-35.
  • Barbieri PG, Marinaccio A, Ferrante P, Scarselli A, Pinelli V, Tassi G. Effects of combined therapies on the survival of pleural mesothelioma patients treated in Brescia, 1982-2006. Tumori 2012 ;98(2):215-9.
  • Sterman DH, Kaiser LR, Albelda SM. Advances in the treat- ment of malignant pleural mesothelioma. Chest 1999;116(2): 504-20.
  • Rodriguez-Panadero F, Antony VB. Pleurodesis: state of the art. Eur Respir J 1997;10(7):1648-54.
  • Astoul P. Malignant mesothelioma. In: Light RW, Lee YC (eds). Textbook of pleural diseases. London: Arnold Press, 2003: 435-44.
  • Aziz T, Jilaihawi A, Prakash D. The management of malignant pleural mesothelioma; single centre experience in 10 years. Eur J Cardiothorac Surg 2002; 22(2):298–305.
  • Zahid I, Sharif S, Routledge T, Scarci M. Is pleurectomy and decortication superior to palliative care in the treatment of malignant pleural mesothelioma? Interact Cardiovasc Thorac Surg 2011;12(5):812-7.

Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması

Year 2012, Volume: 39 Issue: 4, 509 - 512, 01.12.2012
https://doi.org/10.5798/diclemedj.0921.2012.04.0191

Abstract

Amaç: Malign Plevral Mezotelyoma (MPM) plevrayı tutan ve kötü prognozlu bir kanser türüdür. Bu çalışma, sadece destek tedavisi alan ve destek tedavisi ile birlikte plöredez uygulanan MPM hastaları arasındaki farkları inceleme amaçlı planlandı. Gereç ve yöntem: Dicle Üniversitesi Tıp Fakültesi Hastanesinde takip edilen 96 MPM hastasının dosyası retrospektif olarak incelendi. Yaş, cinsiyet, asbest teması, tanı yöntemleri, histopatolojik tip ve tedavi rejimleri verileri kaydedildi. Bulgular: Toplam 96 MPM hastasının yaş ortalaması 60,4 ± 12,6 yıldı. Altmış üç hasta erkek (% 65,6) ve 33 hasta kadındı (% 34,4). Toplam 75 (% 78,1) hastada çevresel asbest teması vardı ve ortalama çevresel asbest teması süresi 33 yıldı. Toplam 63 (% 65,6) hastada epitelyal tip MPM saptandı. Plevral sıvı sitolojisi 30 hastada pozitif saptandı. En sık saptanan semptom 91 hastada olan nefes darlığıydı. Bu hastalardan otuzu sadece destek tedavisi almışken 66 hastaya destek tedavisi ile birlikte plöredez uygulanmıştı. Her iki grubun toplamında ortalama sağkalım süresi yaklaşık 10 aydı. Plöredez uygulanan grupta ortalama sağkalım 10,7 ay iken uygulanmayan grupta ise 9,1 ay idi. Fakat bu fark istatistiksel olarak anlamlı bulunmadı (p= 0,35). Sonuç: Malign Plevral Mezotelyoma, bir çok tedavi seçeneğine dirençli olan ve agresif seyreden bir kanser türüdür. İlerleyici nefes darlığı, bu hastalarda öncelikli yakınmadır ve çoğunlukla plevral sıvıya bağlıdır. Plöredez sıvıyı kontrol altına almada bir seçenektir. Fakat tek başına sağkalıma katkısı görülmemektedir. Bu konuyla ilgili geniş serili çalışmalara ihtiyaç vardır.

References

  • Boutin C, Schlesser M, Frenay C, Astoul P. Malignant pleural mesothelioma. Eur Respir J 1998; 12(4): 972-81.
  • Sterman DH, Kaiser LR, Albelda SM. Advances in the treat- ment of malignant pleural mesothelioma. Chest 1999;116(2): 504-20.
  • Metintaş S, Metintaş M, Uçgun I, Onen U. Malignant me- sothelioma due to environmental exposure to asbestos. Follow up of a Turkish cohort living in a rural area. Chest 2002;122(6):2224-9.
  • Alberts AS, Falkson G, Goedhals L, Vorobiof DA, Van der Merwe CA. Malignant pleural mesothelioma: a disease unaf- fected by current therapeutic maneuvers. J Clin Oncol 1988; 6(3): 527–35.
  • Schouwink H, Korse CM, Bonfrer JM, Hart AA, Baas P. Prog- nostic value of the serum tumour markers Cyfra 21-1 and tissue polypeptide antigen in malignant mesothelioma. Lung Cancer 1999; 25(1): 25–32.
  • Law MR, Gregor A, Hodson ME, Bloom HJ, Turner-Warwick M. Malignant mesothelioma of the pleura: A study of 52 treated and 64 untreated patients. Thorax 1984; 39(4): 255-9.
  • Walker-Renard P, Vaughan LM, Shan SA. Chemical pleurode- sis for malignant pleural effusions. Ann Intern Med 1994;120(1):56-64.
  • Metintas M, Ak G, Erginel S, et al. A retrospective analysis of malignant pleural mesothelioma patients treated either with chemotherapy or best supportive care between 1990 and 2005 A single institution experience. Lung Cancer 2007;55(3):379- 87.
  • Yazicioglu S. Pleural calcification associated with exposure to chrysotile asbestos in southeast Turkey. Chest 1976;70(1):43- 7.
  • Carkanat AI, Abdurrahman A, Abakay O, Cengizhan S, Se- limoglu SH, Senyigit A. The incidence of mesothelioma has not decreased for the last twenty years in Southeast region of Anatolia. Afr Health Sci 2011;11(3): 346-52.
  • Senyiğit A, Babayiğit C, Gökirmak M, Topçu F, Asan E, Coşkunsel M. Incidence of malignant pleural mesothelioma due to environmental asbestos fiber exposure in the southeast of Turkey. Respiration 2000;67(6):610-14.
  • Senyiğit A, Bayram H, Babayiğit C, et al. Malignant pleural mesothelioma caused by environmental exposure to asbestos in the Southeast of Turkey: CT findings in 117 patients. Res- piration 2000;67(6):615-22.
  • Metintaş M, Özdemir N, Hillerdal G. Environmental asbestos exposure and malignant pleural mesothelioma. Respir Med 1999; 93(5): 349-55.
  • Tanrikulu AC, Senyigit A, Dagli CE, Babayigit C, Abakay A. Environmental malignant pleural mesothelioma in Southeast Turkey. Saudi Med J 2006;27(10):1605-7.
  • Zervos MD, Bizekis C, Pass HI. Malignant mesothelioma 2008. Curr Opin Pulm Med 2008; 14(4): 303-9.
  • Selçuk ZT, Cöplü L, Emri S. Malignant pleural mesothelioma due to environmental mineral fiber exposure in Turkey. Anal- ysis of 135 cases. Chest 1992;102(3):790-6.
  • Alberts AS, Falkson G, Goedhals L, Vorobiof DA, Van der Merwe CA. Malignant pleural mesothelioma: A disease unaf- fected by current therapeutic maneuvers. J Clin Oncol 1988; 6(3): 527-35.
  • Barbieri PG, Marinaccio A, Ferrante P, Scarselli A, Pinelli V, Tassi G. Effects of combined therapies on the survival of pleural mesothelioma patients treated in Brescia, 1982-2006. Tumori 2012 ;98(2):215-9.
  • Sterman DH, Kaiser LR, Albelda SM. Advances in the treat- ment of malignant pleural mesothelioma. Chest 1999;116(2): 504-20.
  • Rodriguez-Panadero F, Antony VB. Pleurodesis: state of the art. Eur Respir J 1997;10(7):1648-54.
  • Astoul P. Malignant mesothelioma. In: Light RW, Lee YC (eds). Textbook of pleural diseases. London: Arnold Press, 2003: 435-44.
  • Aziz T, Jilaihawi A, Prakash D. The management of malignant pleural mesothelioma; single centre experience in 10 years. Eur J Cardiothorac Surg 2002; 22(2):298–305.
  • Zahid I, Sharif S, Routledge T, Scarci M. Is pleurectomy and decortication superior to palliative care in the treatment of malignant pleural mesothelioma? Interact Cardiovasc Thorac Surg 2011;12(5):812-7.
There are 23 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Abdullah Çetin Tanrıkulu This is me

Özlem Abakay This is me

Cengizhan Sezgi This is me

Hadice Selimoğlu Şen This is me

Abdurrahman Abakay This is me

Publication Date December 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 4

Cite

APA Tanrıkulu, A. Ç., Abakay, Ö., Sezgi, C., Şen, H. S., et al. (2012). Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması. Dicle Tıp Dergisi, 39(4), 509-512. https://doi.org/10.5798/diclemedj.0921.2012.04.0191
AMA Tanrıkulu AÇ, Abakay Ö, Sezgi C, Şen HS, Abakay A. Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması. diclemedj. December 2012;39(4):509-512. doi:10.5798/diclemedj.0921.2012.04.0191
Chicago Tanrıkulu, Abdullah Çetin, Özlem Abakay, Cengizhan Sezgi, Hadice Selimoğlu Şen, and Abdurrahman Abakay. “Malign Plevral Mezotelyoma hastalarında Destek Tedavisi Ve plöredezin karşılaştırılması”. Dicle Tıp Dergisi 39, no. 4 (December 2012): 509-12. https://doi.org/10.5798/diclemedj.0921.2012.04.0191.
EndNote Tanrıkulu AÇ, Abakay Ö, Sezgi C, Şen HS, Abakay A (December 1, 2012) Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması. Dicle Tıp Dergisi 39 4 509–512.
IEEE A. Ç. Tanrıkulu, Ö. Abakay, C. Sezgi, H. S. Şen, and A. Abakay, “Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması”, diclemedj, vol. 39, no. 4, pp. 509–512, 2012, doi: 10.5798/diclemedj.0921.2012.04.0191.
ISNAD Tanrıkulu, Abdullah Çetin et al. “Malign Plevral Mezotelyoma hastalarında Destek Tedavisi Ve plöredezin karşılaştırılması”. Dicle Tıp Dergisi 39/4 (December 2012), 509-512. https://doi.org/10.5798/diclemedj.0921.2012.04.0191.
JAMA Tanrıkulu AÇ, Abakay Ö, Sezgi C, Şen HS, Abakay A. Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması. diclemedj. 2012;39:509–512.
MLA Tanrıkulu, Abdullah Çetin et al. “Malign Plevral Mezotelyoma hastalarında Destek Tedavisi Ve plöredezin karşılaştırılması”. Dicle Tıp Dergisi, vol. 39, no. 4, 2012, pp. 509-12, doi:10.5798/diclemedj.0921.2012.04.0191.
Vancouver Tanrıkulu AÇ, Abakay Ö, Sezgi C, Şen HS, Abakay A. Malign plevral mezotelyoma hastalarında destek tedavisi ve plöredezin karşılaştırılması. diclemedj. 2012;39(4):509-12.