Serum paraoxonase-1 activities and malondialdehyde levels in patients with epilepsy

Year 2012, Volume: 39 Issue: 4, 557 - 560, 01.12.2012

Mehmet Uğur Çevik Sefer Varol Yavuz Yücel , Eşref Akıl Tahsin Çelepkolu Adalet Arıkanoğlu Hatice Yüksel Mehmet Ufuk Aluçlu

https://doi.org/10.5798/diclemedj.0921.2012.04.0200

Cited By: 8

Abstract

Objectives: We aimed to evaluate antioxidant paraoxonase-1 (PON-1) activity together with malondialdehyde (MDA) (an oxidative stress parameter) levels in patients with epilepsy. Materials and methods: Forty-five epilepsy patients were included in the study and compared with healthy controls (n = 45). The levels of serum MDA and PON-1 activities were measured by the Ohkawa method and the Eckerson method, respectively. Results: Serum MDA level was significantly higher (P = 0.015), whereas PON-1 activity was sigificantly lower (P = 0.011) in the patient group than the controls. Conclusions: Increased reactive oxygen species levels in epilepsy may result in a oxidative stress, which in turn could result in decreased antioxidant PON-1 activity and increased MDA levels.

Keywords

Epilepsy, oxidative stress, malondialdehyde, paraoxonase-1

Epilepsili hastalarda serum paraoksonaz-1 aktivitesi ve malondialdehit düzeyleri

Abstract

Amaç: Amacımız epilepsili hastalarda serumda antioksidan olarak paraoksonaz-1 (PON-1) aktivitesi ve malondialdehit (MDA) (oksidatif stres parametresi) düzeylerini değerlendirmektir.Gereç ve yöntem: Çalışmaya kırk beş epilepsi hastası alındı ve kontrol sağlıklı 45 kişi ile karşılaştırıldı. Serum MDA düzeyleri ve PON-1 aktiviteleri sırasıyla Ohkawa ve Eckerson metodları ile ölçüldü.Bulgular: Serum MDA seviyeleri hasta grubunda (3,97±0,71 nmol/mL) kontol grubuna (3,52±0,95 nmol/mL) göre anlamlı yüksek (p = 0,015) iken, PON-1 aktiviteleri hasta grubunda kontrol grubuna göre anlamlı düşük bulundu (45,17±29,70 U/L ve 66,50±46,15 U/L, p= 0,011).Sonuç: Epilepside reaktif oksijen türlerinin seviyelerinin artması oksidatif stresin bir sonucu olabilir. Bu sebeple antioksidan olarak PON-1 aktivitesi azalırken, MDA düzeyleri artabilir

Keywords

Epilepsi, oksidatif stres, malondialdehit, paraoksonaz-1

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