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Candida albicans menengitis in a newborn with classical galactosemia

Year 2012, Volume: 39 Issue: 4, 587 - 590, 01.12.2012
https://doi.org/10.5798/diclemedj.0921.2012.04.0208

Abstract

Classical galactosemia is a rarely seen carbohydrate metabolism disorder. The frequency of sepsis significantly increases in patients with galactosemia. The most common agent causing sepsis is E. coli. Sepsis due to fungus in patients with galactosemia is rarely reported. Candida is an important cause of sepsis in newborn intensive care units especially in newborns with underlying risk factors such as prematurity and low birth weight. Although the most common etiologic agent of sepsis is E. coli in cases with galactosemia, it should be kept in mind that candida may also be causative agent of sepsis and meningitis in these patients even though there is no underlying risk factor. Also the clinical and laboratory findings of candidiasis may be obscure. For this reason, especially in newborn candida meningitis, the index of suspicion should be kept high for early diagnosis and treatment. In such patients cerebrospinal fluid analysis, culture and brain imaging should be done necessarily, because early diagnosis and treatment will be life saving. In this article we reported a galactosemia case with the diagnosis of meningitis and Candida albicans grown in his blood culture derived on the fourth day of admission to clinic.

References

  • Bosch AM. Classical galactosaemia revisited. J Inherit Metab Dis 2006;29(4):516-25.
  • Boonyawat B, Kamolsilp M, Phavichitr N. Galactosemia in Thai patient at Phramongkutklao Hospital: a case report. J Med Assoc Thai 2005;88(3):275-80.
  • Timmers I, van den Hurk J, Di Salle F, Rubio-Gozalbo ME, Jansma BM. Language production and working memory in classic galactosemia from a cognitive neuroscience per- spective: future research directions. J Inherit Metab Dis 2011;34(2):367-76.
  • Hughes J, Ryan S, Lambert D, et al. Outcomes of siblings with classical galactosemia. J Pediatr 2009;154(5):721-6.
  • Tokatlı A. Galaktozemi taraması. Katkı Pediatri Dergisi 2000;21(2):214-23.
  • İnce E. Çocuklarda invaziv mantar enfeksiyonlarının klinik belirtileri. Çocuk Enf Derg 2007;1(1); 23-8.
  • Moylett EH. Neonatal Candida meningitis. Semin Pediatr Infect Dis 2003;14(2):115-22.
  • Kaufman D. Fungal infection in the very low birthweight infant. Curr Opin Infect Dis 2004;17(3):253-9.
  • Celebi S, Hacimustafaoglu M, Ozdemir O, Ozkaya G. Noso- comial candidaemia in children: results of a 9-year study. Mycoses 2008;51(3):248-57.
  • Rao S, Ali U. Systemic fungal infections in neonates. J Postgrad Med 2005;51:27-9.
  • Chapman RL. Prevention and treatment of Candida infec- tions in neonates. Semin Perinatol 2007;31(1):39-46.
  • Chang MR, Correia FP, Costa LC, et al. Candida blood- stream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil. Rev Inst Med Trop Sao Paulo 2008;50(5):265-8.
  • Özbek E, Tekay F, Pirinççioğlu HÇ. Yoğun bakım hastaları- na ait çeşitli örneklerden izole edilen Candida izolatlarında antifungal direnç. Dicle Tip Derg 2012;39(2):207-12.
  • Verma S, Bharti B, Inusha P. Association of fungal sepsis and galactosemia. Indian J Pediatr 2010;77(6):695-6.

Candida albicans menengitis in a newborn with classical galactosemia

Year 2012, Volume: 39 Issue: 4, 587 - 590, 01.12.2012
https://doi.org/10.5798/diclemedj.0921.2012.04.0208

Abstract

Klasik galaktozemi nadir görülen bir karbonhidrat metabolizma bozukluğudur. Galaktozemili hastalarda sepsis sıklığı belirgin derecede artmıştır. En sık görülen sepsis etkeni E. coli\'dir. Mantar sepsisi galaktozemi hastalarında nadiren bildirilmiştir. Kandida sepsisi yenidoğan yoğun bakım ünitelerinde özellikle prematürite ve düşük doğum ağırlığı gibi altta yatan bir risk faktörü olan bebeklerde önemli bir sepsis nedenidir. Galaktozemi hastalarında en sık sepsis etkeni E. coli olmasına rağmen altta yatan bir risk faktörü olmasa da kandidiyazisin de bu hastalarda bir sepsis ve menenjit etkeni olabileceği akılda tutulmalıdır. Ayrıca kandidiyaziste klinik ve laboratuar bulgular silik olabilir. Bu nedenle özellikle neonatal kandida menenjitinde erken tanı ve tedavi için şüphe indeksini yüksek tutmak gerekir. Böyle hastalarda BOS analizi, kültürü ve beyin görüntülenmesi mutlaka yapılmalıdır. Çünkü erken tanı ve tedavi hayat kurtarıcı olacaktır. Bu yazıda yatışının dördüncü gününde alınan kan kültüründe Candida albicans üreyen ve menenjit tanısı konan bir klasik galaktozemi olgusu sunuldu.

References

  • Bosch AM. Classical galactosaemia revisited. J Inherit Metab Dis 2006;29(4):516-25.
  • Boonyawat B, Kamolsilp M, Phavichitr N. Galactosemia in Thai patient at Phramongkutklao Hospital: a case report. J Med Assoc Thai 2005;88(3):275-80.
  • Timmers I, van den Hurk J, Di Salle F, Rubio-Gozalbo ME, Jansma BM. Language production and working memory in classic galactosemia from a cognitive neuroscience per- spective: future research directions. J Inherit Metab Dis 2011;34(2):367-76.
  • Hughes J, Ryan S, Lambert D, et al. Outcomes of siblings with classical galactosemia. J Pediatr 2009;154(5):721-6.
  • Tokatlı A. Galaktozemi taraması. Katkı Pediatri Dergisi 2000;21(2):214-23.
  • İnce E. Çocuklarda invaziv mantar enfeksiyonlarının klinik belirtileri. Çocuk Enf Derg 2007;1(1); 23-8.
  • Moylett EH. Neonatal Candida meningitis. Semin Pediatr Infect Dis 2003;14(2):115-22.
  • Kaufman D. Fungal infection in the very low birthweight infant. Curr Opin Infect Dis 2004;17(3):253-9.
  • Celebi S, Hacimustafaoglu M, Ozdemir O, Ozkaya G. Noso- comial candidaemia in children: results of a 9-year study. Mycoses 2008;51(3):248-57.
  • Rao S, Ali U. Systemic fungal infections in neonates. J Postgrad Med 2005;51:27-9.
  • Chapman RL. Prevention and treatment of Candida infec- tions in neonates. Semin Perinatol 2007;31(1):39-46.
  • Chang MR, Correia FP, Costa LC, et al. Candida blood- stream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil. Rev Inst Med Trop Sao Paulo 2008;50(5):265-8.
  • Özbek E, Tekay F, Pirinççioğlu HÇ. Yoğun bakım hastaları- na ait çeşitli örneklerden izole edilen Candida izolatlarında antifungal direnç. Dicle Tip Derg 2012;39(2):207-12.
  • Verma S, Bharti B, Inusha P. Association of fungal sepsis and galactosemia. Indian J Pediatr 2010;77(6):695-6.
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Case Reports
Authors

Hüseyin Altunhan This is me

Ali Annagür This is me

Sabahattin Ertuğrul This is me

Murat Konak This is me

Hasan Ali Yüksekkaya This is me

Rahmi Örs This is me

Publication Date December 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 4

Cite

APA Altunhan, H., Annagür, A., Ertuğrul, S., Konak, M., et al. (2012). Candida albicans menengitis in a newborn with classical galactosemia. Dicle Tıp Dergisi, 39(4), 587-590. https://doi.org/10.5798/diclemedj.0921.2012.04.0208
AMA Altunhan H, Annagür A, Ertuğrul S, Konak M, Yüksekkaya HA, Örs R. Candida albicans menengitis in a newborn with classical galactosemia. diclemedj. December 2012;39(4):587-590. doi:10.5798/diclemedj.0921.2012.04.0208
Chicago Altunhan, Hüseyin, Ali Annagür, Sabahattin Ertuğrul, Murat Konak, Hasan Ali Yüksekkaya, and Rahmi Örs. “Candida Albicans Menengitis in a Newborn With Classical Galactosemia”. Dicle Tıp Dergisi 39, no. 4 (December 2012): 587-90. https://doi.org/10.5798/diclemedj.0921.2012.04.0208.
EndNote Altunhan H, Annagür A, Ertuğrul S, Konak M, Yüksekkaya HA, Örs R (December 1, 2012) Candida albicans menengitis in a newborn with classical galactosemia. Dicle Tıp Dergisi 39 4 587–590.
IEEE H. Altunhan, A. Annagür, S. Ertuğrul, M. Konak, H. A. Yüksekkaya, and R. Örs, “Candida albicans menengitis in a newborn with classical galactosemia”, diclemedj, vol. 39, no. 4, pp. 587–590, 2012, doi: 10.5798/diclemedj.0921.2012.04.0208.
ISNAD Altunhan, Hüseyin et al. “Candida Albicans Menengitis in a Newborn With Classical Galactosemia”. Dicle Tıp Dergisi 39/4 (December 2012), 587-590. https://doi.org/10.5798/diclemedj.0921.2012.04.0208.
JAMA Altunhan H, Annagür A, Ertuğrul S, Konak M, Yüksekkaya HA, Örs R. Candida albicans menengitis in a newborn with classical galactosemia. diclemedj. 2012;39:587–590.
MLA Altunhan, Hüseyin et al. “Candida Albicans Menengitis in a Newborn With Classical Galactosemia”. Dicle Tıp Dergisi, vol. 39, no. 4, 2012, pp. 587-90, doi:10.5798/diclemedj.0921.2012.04.0208.
Vancouver Altunhan H, Annagür A, Ertuğrul S, Konak M, Yüksekkaya HA, Örs R. Candida albicans menengitis in a newborn with classical galactosemia. diclemedj. 2012;39(4):587-90.