Collagen cross-linking therapy in patients with keratoconus

Year 2012, Volume: 39 Issue: 4, 604 - 608, 01.12.2012

Lokman Aslan Murat Aslankurt Ahmet Metin Başkan

https://doi.org/10.5798/diclemedj.0921.2012.04.0211

Abstract

Keratoconus affecting young population is a progressive eye disease. This disease may remain silent until complain of visual impairment is appeared. By using the high-quality imaging techniques disease now can be diagnosed earlier. The goal of keratoconus treatment is to improve visual acuity and to prevent the progression of the disease. Although the previous treatment methods initially provided slightly improvement of visual acuity, could not prevent keratoconus progression. However, collagen cross-link (CCL) treatment both halts the progression of the disease and provides an increased vision. Since the side effect of the treatment is less and implementation is easier, CCL provides an important advantage for these patients and this technique becomes common day by day.

Keywords

Keratoconus, cross-linking, cornea.

Keratokonus hastalarında kollajen çapraz bağlama tedavisi

Abstract

Genç nüfusun etkilendiği keratokonus ilerleyici bir göz hastalığıdır. Hastalık görme azalması şikâyeti ortaya çıkıncaya kadar sessiz kalabilir ve erken dönemde tanı konulamayabilir. Günümüzde gittikçe yaygınlaşan güncel görüntüleme yöntemleri hastalığa erken tanı koymamıza yardımcı olmaktadır. Keratokonus tedavisinde amaç görmeyi artırmak ve hastalığın ilerlemesini durdurmaktır. Güncel tedavide kullanılan yöntemler başlangıçta görmede artış sağlamakla birlikte hastalığın ilerlemesine etki etmemektedir. Ancak kollajen çapraz bağlama tedavisi görmede artış sağlamakla birlikte hastalığın ilerlemesini de durdurmaktadır. Bu tekniğin uygulanması nispeten kolay ve yan etkilerinin az olması önemli bir avantaj sağlamakta ve tedavide kullanımı gün geçtikçe yaygınlaşmaktadır.

Keywords

Keratokonus, çapraz bağlama, kornea.

References

• Kok YO, Tan GF, Loon SC. Review: keratoconus in Asia. Cornea 2012;31(5):581-93
• Or H. Keratokonüsün etiyopatogenezine güncel bir bakış. Turk J Ophthalmol 2011; 41: 339-47.
• Ku JY, Niederer RL, Patel DV, Sherwin T, McGhee CN. La- ser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology 2008;115(5):845-50.
• Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998; 42(4):297-319.
• Barnett M, Mannis MJ. Contact lenses in the management of keratoconus. Cornea 2011;30(12):1510-6.
• Tu KL, Batterbury M, Kaye SB. Intrastromal corneal ring segments: Effect of relationship between alignment and topographic keratometric meridians. J Cataract Refract Surg 2012;38(8):1432-9.
• Sögütlü SE, Kubaloglu A, Unal M et al. Penetrating kerato- plasty versus deep anterior lamellar keratoplasty: compari- son of optical and visual quality outcomes. Br J Ophthalmol 2012;96(8):1063-7.
• Dahl BJ, Spotts E, Truong JQ. Corneal collagen cross- linking: An introduction and literature review. Optometry 2012;83(1):33-42.
• Arne JL, Fournié P. Keratoconus, the most common corneal dystrophy. Can keratoplasty be avoided? Bull Acad Natl Med 2011;195(1):113-29.
• Touboul D, Trichet E, Binder PS, Praud D, Seguy C, Co- lin J. Comparison of front-surface corneal topography and Bowman membrane specular topography in keratoconus. J Cataract Refract Surg 2012;38(6):1043-9.
• Kling S, Ginis H, Marcos S. Corneal Biomechanical Prop- erties from Two-Dimensional Corneal Flap Extensiometry: Application to UV-Riboflavin Cross-Linking. Invest Oph- thalmol Vis Sci 2012;53(8):5010-5.
• Hafezi F, Mrochen M, Iseli HP, Seiler T. Collagen crosslink- ing with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 2009;35(4):621-4.
• Bottós KM, Schor P, Dreyfuss JL, Nader HB, Chamon W. Effect of corneal epithelium on ultraviolet-A and riboflavin absorption. Arq Bras Oftalmol 2011;74(5):348-51.
• Wollensak G. Crosslinking treatment of progressive kerato- conus. Ophthalmology: new hope 2006;17(4):356-60.
• Coskunseven E, Jankov MR, Hafezi F. Contralateral eye study of cornealcollagen cross-linking with riboflavin and UVA irradiation in patients with keratoconus. J Refract Surg 2009;25(4):371-6.
• Caporossi A, Mazotta C, Baiocchi S, Caporossi T, Denaro R. Age-related long-term functional results after riboflavin UV A corneal cross-linking. J Ophthalmol 2011;20(11):1123-7.
• Caporossi A, Mazzotta C, Baiocchi S, Caporossi T, Denaro R, Balestrazzi A. Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients. Cornea 2012;31(3):227- 31.
• Kymionis GD, Portaliou DM, Diakonis VF, Kounis GA, Panagopoulou SI, Grentzelos MA. Corneal Collagen Cross-linking With Riboflavin and Ultraviolet-A Irra- diation in Patients With Thin Corneas. Am J Ophthalmol 2012;153(1):24-8.
• Raiskup F, Spoerl E. Corneal cross-linking with hypo-os- molar riboflavin solution in thin keratoconic corneas. Am J Ophthalmol 2011;152(1):28-32.
• Ghanem VC, Ghanem RC, de Oliveira R. Postoperative Pain After Corneal Collagen Cross-Linking. Cornea. 2012 Apr 27. [Epub ahead of print]
• Filippello M, Stagni E, O’Brart D. Transepithelial corneal collagen crosslinking: Bilateral study. J Cataract Refract Surg 2012;38(2):283-91.
• Zhang ZY, Zhang XR. Efficacy and safety of transepithe- lial corneal collagen crosslinking. J Cataract Refract Surg 2012; 38(17):1304-5.
• Alió JL, Toffaha BT, Piñero DP, Klonowski P, Javaloy J. Cross-linking in progressive keratoconus using an epithe- lial debridement or intrastromal pocket technique after pre- vious corneal ring segment implantation. J Refract Surg. 2011;27(10):737-43.
• Lanchares E, del Buey MA, Cristóbal JA, Lavilla L, Calvo B. Biomechanical property analysis after corneal collagen cross-linking in relation to ultraviolet A irradiation time. Graefes Arch Clin Exp Ophthalmol 2011;249(8):1223-7
• Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze af- ter riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg 2009;25(9):824-8
• Vinciguerra P, Albè E, Romano MR, Sabato L, Trazza S. Stromal opacity after cross-linking. J Refract Surg 2012; 28(3):165.
• Camesasca FI, Vinciguerra P, Seiler T. Bilateral ring-shaped intrastromal opacities after corneal cross-linking for kerato- conus. J Refract Surg 2011;27(12):913-5.
• Yuksel N, Bilgihan K, Hondur AM. Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultravi- olet-A for progressive keratoconus. Int Ophthalmol 2011; 31(6):513-5.
• Labiris G, Kaloghianni E, Koukoula S, Zissimopoulos A, Kozobolis VP. Corneal melting after collagen cross-linking for keratoconus: a case report. J Med Case Reports 2011 16;5:152
• Vimalin J, Gupta N, Jambulingam M, Padmanabhan P, Madhavan HN. The Effect of Riboflavin-UV-A Treatment on Corneal Limbal Epithelial Cells-A Study on Human Ca- daver Eyes. Cornea 2012 Jun 5 [Epub ahead of print].