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Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease

Year 2012, Volume: 39 Issue: 3, 325 - 330, 01.09.2012
https://doi.org/10.5798/diclemedj.0921.2012.03.0152

Abstract

Objectives: Osteoporosis is commonly developed due to
natural course of Behçet’s disease (BD) and therapeutic
agents. It was aimed to investigate levels of osteoprotegerin
and TNF-α (tumor necrosis factor), and bone mineral density
(BMD) and correlation between them in BD.
Materials and methods: The study included two groups
as the study and the control group. Serum levels of TNF-α,
osteoprotegerin, osteocalcine, erythrocyte sedimentation rate
(ESR), C-reactive protein (CRP), and urinary creatinine and
deoxypyridinoline along with BMD level were evaluated and
compared. Correlation between TNF-α and osteoprotegerin
level was investigated.
Results: The study enrolled 41 BD patients and 36 agedmatched control subjects. Mean age was 42.26±11.64 and
41.66±70.99, in the study and control groups, respectively.
There was no significant difference in body mass index
(BMI) of subjects between groups (p>0.05). Level of TNF-α
(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine
(p=0.041) was significantly higher in the study group compared to the control group. Osteoprotegerin was lower in
BD patients, but the difference was not significant (p>0.05).
Urinary deoxypyridinoline/ urinary creatinine ratio in patients
with BD was significantly higher than those in control group
(p=0.030). Patients had significantly lower BMD comparfed
to the control group, except L2-L4 vertebral area (p<0.001,
p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 and
p=0.111, respectively). No correlation was found between
TNF-α and osteoprotegerin.
Conclusions: The present study indicated that TNF-α and
BMD was negatively correlated with each other and TNF-α
had an effect on osteoporotic process in patients with BD.
Osteoprotegerin level was not decreased, and not correlated
with TNF-α.

Behçet hastalarında serum TNF- α ve osteoprotegerin düzeyi ve kemik kitle yoğunluğu

Year 2012, Volume: 39 Issue: 3, 325 - 330, 01.09.2012
https://doi.org/10.5798/diclemedj.0921.2012.03.0152

Abstract

Amaç: Behçet hastalığı (BH)’nın doğal seyri sırasında ya
da kullanılan ilaçlara bağlı olarak osteoporoz gelişebilir.
Çalışmanın amacı BH’nda osteoprotegerin ve tümor nekroz faktör (TNF-α) düzeyleri ve bunlar arasındaki korelasyonu araştırmaktır.
Gereç ve yöntem: Çalışmaya, hasta grubu ve kontrol
grubu olarak iki grup alındı. TNF-α, osteoprotegerin, osteokalsin, sedimantasyon, CRP, idrar kreatin ve deoksipridinolin düzeyleri ile beraber kemik mineral dansitometrisi
(KMD) ölçüldü ve iki grup karşılaştırıldı.
Bulgular: Çalışma grubuna 41 hasta, kontrol grubuna 36
hasta alındı. Çalışma ve kontrol grubunun yaş ortalaması sırasıyla 42.26±11.64 ve 41.66±70.99 bulundu. Vücut
kitle indeksi yönünden iki grup arasında fark bulunmadı.
TNF-α (p<0.001), deokspiridinolin (p<0.001) ve osteokalsin (p=0.041) düzeyleri kontrol grubundan önemli oranda
yüksek bulundu. Osteoprotogerin düzeyi hasta grubunda
düşüktü ancak anlamlı düzeyde değildi (p>0.05). İdrar deoxypyridinoline/ idrar kreatinin oranı hasta grubunda kontrol grubuna göre anlamlı yüksekti (p=0.03). Hasta grubun
KMD ölçümü; L2-L4 hariç, kontrol grubuna göre anlamlı
oranda düşüktü (sırasıyla p<0.001, p<0.001, p=0.035,
p<0.001, p=0.012, p<0.001, p<0.001 ve p=0.111). TNF-α
ve osteoprotegerin arasında korelasyon saptanmadı.
Sonuç: Bu çalışmada TNF-α ve KMD arasında negatif
korelasyon saptandı ve TNF-α’nın, BH’da osteoporotik
süreci etkilediği bulundu. Osteoprotogerin düzeyi düşüklüğü anlamlı değildi ve TNF-α ile korele değildi.

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Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Ali Kutlucan This is me

Sevket Ercan Tunc This is me

Davut Baltacı This is me

Mehmet Sahin This is me

Mustafa Ozsahin This is me

Recep Sütcü This is me

Fatih Ermis This is me

Harun Süslü This is me

Publication Date September 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 3

Cite

APA Kutlucan, A., Tunc, S. E., Baltacı, D., Sahin, M., et al. (2012). Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi, 39(3), 325-330. https://doi.org/10.5798/diclemedj.0921.2012.03.0152
AMA Kutlucan A, Tunc SE, Baltacı D, Sahin M, Ozsahin M, Sütcü R, Ermis F, Süslü H. Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. diclemedj. September 2012;39(3):325-330. doi:10.5798/diclemedj.0921.2012.03.0152
Chicago Kutlucan, Ali, Sevket Ercan Tunc, Davut Baltacı, Mehmet Sahin, Mustafa Ozsahin, Recep Sütcü, Fatih Ermis, and Harun Süslü. “Serum Levels of TNF-α and Osteoprotegerin and Bone Mineral Density in Patients With Behçet’s Disease”. Dicle Tıp Dergisi 39, no. 3 (September 2012): 325-30. https://doi.org/10.5798/diclemedj.0921.2012.03.0152.
EndNote Kutlucan A, Tunc SE, Baltacı D, Sahin M, Ozsahin M, Sütcü R, Ermis F, Süslü H (September 1, 2012) Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. Dicle Tıp Dergisi 39 3 325–330.
IEEE A. Kutlucan, “Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease”, diclemedj, vol. 39, no. 3, pp. 325–330, 2012, doi: 10.5798/diclemedj.0921.2012.03.0152.
ISNAD Kutlucan, Ali et al. “Serum Levels of TNF-α and Osteoprotegerin and Bone Mineral Density in Patients With Behçet’s Disease”. Dicle Tıp Dergisi 39/3 (September 2012), 325-330. https://doi.org/10.5798/diclemedj.0921.2012.03.0152.
JAMA Kutlucan A, Tunc SE, Baltacı D, Sahin M, Ozsahin M, Sütcü R, Ermis F, Süslü H. Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. diclemedj. 2012;39:325–330.
MLA Kutlucan, Ali et al. “Serum Levels of TNF-α and Osteoprotegerin and Bone Mineral Density in Patients With Behçet’s Disease”. Dicle Tıp Dergisi, vol. 39, no. 3, 2012, pp. 325-30, doi:10.5798/diclemedj.0921.2012.03.0152.
Vancouver Kutlucan A, Tunc SE, Baltacı D, Sahin M, Ozsahin M, Sütcü R, Ermis F, Süslü H. Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease. diclemedj. 2012;39(3):325-30.