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İnflamasyonda trombositlerin rolü

Year 2012, Volume: 39 Issue: 3, 455 - 457, 01.09.2012
https://doi.org/10.5798/diclemedj.0921.2012.03.0181

Abstract

İnflamasyon patolojik etkenlere karşı canlı dokular tarafından oluşturulan, patojeni uzaklaştırmaya yarayan ve iyileşme sürecini başlatan son derece önemli bir olaydır. Mikroorganizmalar, fiziksel ve kimyasal travmalar, termal yaralanma, iskemi ve immün reaksiyonlar inflamasyon nedeni olarak gösterilebilir. Plateletler, nükleusa sahip olmayan ve kemik iliğinde megakaryositlerden üretilen hücreler olup kanamanın durdurulması ve hemostazın devamında rol almasının yanısıra inflamasyonda da önemli rol almaktadır. Nötrofil ve makrofajlara benzer şekilde, inflamasyon mekanizmasına etki edecek çeşitli sitokin üretimi ve salınımı yaparlar. Bu derlemede inflamasyonda plateletlerin rolleri ve inflamasyonun plateletler üzerine etkileri tartışılacaktır.

References

  • Janeway CA, Travers P, Walport M, and Shlomchik M. The immune system in health and disease. 6th ed. 2005, Garland Science Publishing. New York
  • Rather LJ. Disturbance of function (functio laesa): the legend- ary fifth alen to the four cardinal signs of . 303-22. cardinal sign of inflammation, added by G Celsus. Bull N Y Acad Med 1971; 47(3): 303-22.
  • Maynard DM, Heijnen HF, Horne MK, White JG, and Gahl WA. Proteomic analysis of platelet alphagranules using mass spectrometry. J Thromb Haemost 2007; 5(9): 1945-55.
  • Italiano JE, Richardson JL, Patel Hett S. Angiogenesis is regu- lated by a novel mechanism: proand antiangiogenic proteins are organized into separate platelet alpha granules and dif- ferentially released. Blood 2008;111(3): 1227-33.
  • Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105 (Suppl 1): p.13-33
  • Reed GL. Platelet Secretion, in Platelets, A.D. Michelson, Edi- tor. Elsevier Science 2007; p. 309-18
  • Nathan C. Points of control in inflammation. Nature 2002;420(7):846-52.
  • Gawaz, M. Role of platelets in coronary thrombosis and re- perfusion of ischemic myocardium. Cardiovasc Res 2004; 61(3): 498-511.
  • Hawrylowicz CM, Howells GL, Feldmann M. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 1991; 174(6) :785-90.
  • Kaplanski G. Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism. Blood 1994; 84: 4242-8.
  • Gawaz M. Platelets induce alterations of chemotactic and ad- hesive properties of endothelial cells mediated through an interleukin-1- dependent mechanism. Implications for ath- erogenesis. Atherosclerosis 2000; 148(12):75-85.
  • Lievens D, von Hundelshausen P. Platelets in atherosclerosis Thromb Haemost 2011;106(5): 827-38.
  • Shi G, Morrell CN. Platelets as initiators and mediators of in- flammation at the vessel wall. Thromb Res. 2011;127(5):387-90.
  • Huo Y, Schober A, Forlow SB, et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apo- lipoprotein E. Nat Med. 2003; 9(3): 61-7.
  • von Hundelshausen P, Weber KS, Huo Y, et al. RANTES deposi- tion by platelets triggers monocyte arrest on inflamed and ath- erosclerotic endothelium. Circulation. 2001;103(12): 1772-7.
  • Levi M, ten Cate H, Bauer KA, et al. Inhibition of endotoxin- induced activation of coagulation and fibrinolysis by pent- oxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93(1): 114-20.
  • Pixley RA, De LC, Page JD, et al. The contact system con- tributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia: in vivo use of a monoclonal anti-factor XII antibody to block contact activation in ba- boons. J Clin Invest 1993;91(1): 61-8.
  • Schouten M, Wiersinga WJ, Levi M. Poll T Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 2008; 83(6): 536-45.
  • Blanco J, Muriel-Bombı´n A, Sagredo V. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multi- centre study. Crit Care 2008; 12(6): 158-72.
  • Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM The platelet-activating factor signaling system and its regu- lators in syndromes of inflammation and thrombosis. Crit Care Med 2002; 30(2):294-301
  • Moons AH, Levi M, Peters RJ. Tissue factor and coronary artery disease. Cardiovasc Res 2002;53(3): 313-25.
  • Franco RF, de Jonge E, Dekkers PE, et al. The in vivo kinet- ics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation. Blood 2000; 96(9) : 554-9.
  • Li Z, Yang F, Dunn S, Kendall A, Gross K, Susan S. Smyth Platelets as immune mediators: Their role in host defense re- sponses and sepsis Thrombosis Research 2011; 127: 184-88
  • Boldt J, Menges T, Wollbru¨ck M et al. Platelet function in critically ill patients. Chest 1994;106(6): 899-903.
  • Potempa LA, Zeller JM, Fiedel BA, Kinoshita CM, Gewurz H. Stimulation of human neutrophils, monocytes, and plate- lets by modified Creactive protein (CRP) expressing a neo- antigenic specificity. Inflammation, 1988; 12(4): 391-405.
  • El Kebir D, Zhang Y, Potempa LA, C-reactive protein-de- rived peptide 201-206 inhibits neutrophil adhesion to en- dothelial cells and platelets through CD32. J Leukoc Biol. 2011; 90(6):1167-75.
  • Fitzgerald JR, Foster, TJ, and Cox D.The interaction of bacte- rial pathogens with platelets. Nat Rev Microbiol 2006. 4(6): 445-57.
  • Youssefian T, Drouin A, Masse JM, Guichard J, Cramer EM. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002;99(11):4021-9.
  • Usui Y, Ohshima Y, Ichiman Y, Ohtomo T, Suganuma M, and Yoshida K. Platelet aggregation induced by strains of vari- ous species of coagulasenegative staphylococci. Microbiol Immunol 1991;35(1): 915-26.
  • Usui Y, Ichiman Y, Suganuma M, and Yoshida K. Platelet aggregation by strains of enterococci. Microbiol Immunol 1991; 35(11): 933-42.
  • Byrne MF, Kerrigan SW, Corcoran PA. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to in- duce platelet aggregation. Gastroenterology 2003; 124(7): 1846-54.

Role of platelets in inflammation

Year 2012, Volume: 39 Issue: 3, 455 - 457, 01.09.2012
https://doi.org/10.5798/diclemedj.0921.2012.03.0181

Abstract

Inflammation, which is extremely useful process for human body is the response of living vascular tissues to pathological phenomena that removes the pathogens and initiates the healing procedure. Microorganisms, physical trauma, chemical, mechanical, irradiation, or thermal injury, ischemia and immune reactions are most common causes of this exceptionally important event for human body. Platelets are non-nucleated cells in blood that produced in bone marrow as derived from megakaryocytes. Apart from stop bleeding and achieving hemostasis there are incredibly important roles of platelets in inflammation. Platelets contain important mediators for inflammation like neutrophils or macrophages and can alter the course of mechanism. In this article changing platelet function in inflammation and the effect of these functions to the process of inflammation will be discussed.

References

  • Janeway CA, Travers P, Walport M, and Shlomchik M. The immune system in health and disease. 6th ed. 2005, Garland Science Publishing. New York
  • Rather LJ. Disturbance of function (functio laesa): the legend- ary fifth alen to the four cardinal signs of . 303-22. cardinal sign of inflammation, added by G Celsus. Bull N Y Acad Med 1971; 47(3): 303-22.
  • Maynard DM, Heijnen HF, Horne MK, White JG, and Gahl WA. Proteomic analysis of platelet alphagranules using mass spectrometry. J Thromb Haemost 2007; 5(9): 1945-55.
  • Italiano JE, Richardson JL, Patel Hett S. Angiogenesis is regu- lated by a novel mechanism: proand antiangiogenic proteins are organized into separate platelet alpha granules and dif- ferentially released. Blood 2008;111(3): 1227-33.
  • Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011; 105 (Suppl 1): p.13-33
  • Reed GL. Platelet Secretion, in Platelets, A.D. Michelson, Edi- tor. Elsevier Science 2007; p. 309-18
  • Nathan C. Points of control in inflammation. Nature 2002;420(7):846-52.
  • Gawaz, M. Role of platelets in coronary thrombosis and re- perfusion of ischemic myocardium. Cardiovasc Res 2004; 61(3): 498-511.
  • Hawrylowicz CM, Howells GL, Feldmann M. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 1991; 174(6) :785-90.
  • Kaplanski G. Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism. Blood 1994; 84: 4242-8.
  • Gawaz M. Platelets induce alterations of chemotactic and ad- hesive properties of endothelial cells mediated through an interleukin-1- dependent mechanism. Implications for ath- erogenesis. Atherosclerosis 2000; 148(12):75-85.
  • Lievens D, von Hundelshausen P. Platelets in atherosclerosis Thromb Haemost 2011;106(5): 827-38.
  • Shi G, Morrell CN. Platelets as initiators and mediators of in- flammation at the vessel wall. Thromb Res. 2011;127(5):387-90.
  • Huo Y, Schober A, Forlow SB, et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apo- lipoprotein E. Nat Med. 2003; 9(3): 61-7.
  • von Hundelshausen P, Weber KS, Huo Y, et al. RANTES deposi- tion by platelets triggers monocyte arrest on inflamed and ath- erosclerotic endothelium. Circulation. 2001;103(12): 1772-7.
  • Levi M, ten Cate H, Bauer KA, et al. Inhibition of endotoxin- induced activation of coagulation and fibrinolysis by pent- oxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93(1): 114-20.
  • Pixley RA, De LC, Page JD, et al. The contact system con- tributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia: in vivo use of a monoclonal anti-factor XII antibody to block contact activation in ba- boons. J Clin Invest 1993;91(1): 61-8.
  • Schouten M, Wiersinga WJ, Levi M. Poll T Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 2008; 83(6): 536-45.
  • Blanco J, Muriel-Bombı´n A, Sagredo V. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multi- centre study. Crit Care 2008; 12(6): 158-72.
  • Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM The platelet-activating factor signaling system and its regu- lators in syndromes of inflammation and thrombosis. Crit Care Med 2002; 30(2):294-301
  • Moons AH, Levi M, Peters RJ. Tissue factor and coronary artery disease. Cardiovasc Res 2002;53(3): 313-25.
  • Franco RF, de Jonge E, Dekkers PE, et al. The in vivo kinet- ics of tissue factor messenger RNA expression during human endotoxemia: relationship with activation of coagulation. Blood 2000; 96(9) : 554-9.
  • Li Z, Yang F, Dunn S, Kendall A, Gross K, Susan S. Smyth Platelets as immune mediators: Their role in host defense re- sponses and sepsis Thrombosis Research 2011; 127: 184-88
  • Boldt J, Menges T, Wollbru¨ck M et al. Platelet function in critically ill patients. Chest 1994;106(6): 899-903.
  • Potempa LA, Zeller JM, Fiedel BA, Kinoshita CM, Gewurz H. Stimulation of human neutrophils, monocytes, and plate- lets by modified Creactive protein (CRP) expressing a neo- antigenic specificity. Inflammation, 1988; 12(4): 391-405.
  • El Kebir D, Zhang Y, Potempa LA, C-reactive protein-de- rived peptide 201-206 inhibits neutrophil adhesion to en- dothelial cells and platelets through CD32. J Leukoc Biol. 2011; 90(6):1167-75.
  • Fitzgerald JR, Foster, TJ, and Cox D.The interaction of bacte- rial pathogens with platelets. Nat Rev Microbiol 2006. 4(6): 445-57.
  • Youssefian T, Drouin A, Masse JM, Guichard J, Cramer EM. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002;99(11):4021-9.
  • Usui Y, Ohshima Y, Ichiman Y, Ohtomo T, Suganuma M, and Yoshida K. Platelet aggregation induced by strains of vari- ous species of coagulasenegative staphylococci. Microbiol Immunol 1991;35(1): 915-26.
  • Usui Y, Ichiman Y, Suganuma M, and Yoshida K. Platelet aggregation by strains of enterococci. Microbiol Immunol 1991; 35(11): 933-42.
  • Byrne MF, Kerrigan SW, Corcoran PA. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to in- duce platelet aggregation. Gastroenterology 2003; 124(7): 1846-54.
There are 31 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Kadir Serkan Yalçın This is me

Gözde Tahtacı This is me

Özlem Şahin Balçık This is me

Publication Date September 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 3

Cite

APA Yalçın, K. S., Tahtacı, G., & Balçık, Ö. Ş. (2012). İnflamasyonda trombositlerin rolü. Dicle Tıp Dergisi, 39(3), 455-457. https://doi.org/10.5798/diclemedj.0921.2012.03.0181
AMA Yalçın KS, Tahtacı G, Balçık ÖŞ. İnflamasyonda trombositlerin rolü. diclemedj. September 2012;39(3):455-457. doi:10.5798/diclemedj.0921.2012.03.0181
Chicago Yalçın, Kadir Serkan, Gözde Tahtacı, and Özlem Şahin Balçık. “İnflamasyonda Trombositlerin Rolü”. Dicle Tıp Dergisi 39, no. 3 (September 2012): 455-57. https://doi.org/10.5798/diclemedj.0921.2012.03.0181.
EndNote Yalçın KS, Tahtacı G, Balçık ÖŞ (September 1, 2012) İnflamasyonda trombositlerin rolü. Dicle Tıp Dergisi 39 3 455–457.
IEEE K. S. Yalçın, G. Tahtacı, and Ö. Ş. Balçık, “İnflamasyonda trombositlerin rolü”, diclemedj, vol. 39, no. 3, pp. 455–457, 2012, doi: 10.5798/diclemedj.0921.2012.03.0181.
ISNAD Yalçın, Kadir Serkan et al. “İnflamasyonda Trombositlerin Rolü”. Dicle Tıp Dergisi 39/3 (September 2012), 455-457. https://doi.org/10.5798/diclemedj.0921.2012.03.0181.
JAMA Yalçın KS, Tahtacı G, Balçık ÖŞ. İnflamasyonda trombositlerin rolü. diclemedj. 2012;39:455–457.
MLA Yalçın, Kadir Serkan et al. “İnflamasyonda Trombositlerin Rolü”. Dicle Tıp Dergisi, vol. 39, no. 3, 2012, pp. 455-7, doi:10.5798/diclemedj.0921.2012.03.0181.
Vancouver Yalçın KS, Tahtacı G, Balçık ÖŞ. İnflamasyonda trombositlerin rolü. diclemedj. 2012;39(3):455-7.